Injectable alginate/hydroxyapatite gel scaffold combined with gelatin microspheres for drug delivery and bone tissue engineering

Yan, Jingxuan; Miao, Yuting; Tan, Huaping; Zhou, Ting; Ling, Zhonghua; Chen, Yong; Xing, Xiaodong; Hu, Xiaohong

doi:10.1016/j.msec.2016.02.071

Cited by 194 publications

(128 citation statements)

References 36 publications

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“…In the last decades, lot of research has been performed on biodegradable materials with medical applications [4,5]. The goal is to obtain materials susceptible to be used as temporary implants, for which a second surgery is not necessary and no material is left in the body that could lead to possible inflammation or long-term allergic reactions.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Cytocompatibility, biofilm assembly and corrosion behavior of Mg-HAP composites processed by extrusion

Campo

Savoini

Jordão

et al. 2017

Materials Science and Engineering: C

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In this work the cytocompatibility of pure magnesium and Mg-xHAP composites (x=5, 10 and 15wt%) fabricated by powder metallurgy routes has been investigated. The materials were produced from raw HAP powders with particle mean sizes of 6μm (S-xHAP) or 25μm (L-xHAP). The biocompatibility study has been performed for MC3T3 cells (osteoblasts/osteoclasts) and L929 fibroblasts. The results indicate that S-Mg (pure magnesium), S-10HAP and L-10HAP composites are the materials with the best biocompatibility. The ability of S. aureus bacteria to assemble biofilms was also evaluated. Biofilm formation assays showed that these materials are not particular prone to colonization and biofilm assembly is strain dependent. The corrosion resistance of S-Mg, S-10HAP and L-10HAP materials immersed in the media used for the cells culture has also been analyzed. Different trends in the corrosion resistance have been found: S-Mg and S-10HAP show a very high resistance to corrosion whereas the corrosion of L-10HAP steadily increases with time.

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Section: Accepted Manuscriptmentioning

confidence: 99%

Cytocompatibility, biofilm assembly and corrosion behavior of Mg-HAP composites processed by extrusion

Campo

Savoini

Jordão

et al. 2017

Materials Science and Engineering: C

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show abstract

“…Regarding materials structure, a paper published by Ting Pan is dedicated to the study of a material that can provide sufficient amount of pores in order to get adequate mechanical properties, using to this end Gelatin/Alginate scaffolds, so they can be used for cells and/or drugs materials encapsulation [53]. An approximation where the activity of the hybrid material is tested with similar scaffolds, is found on Chen´s paper [54], where the potential application of this gel scaffold in bone tissue engineering was confirmed by encapsulation behavior of osteoblasts.…”

Section: Materials Available For Am For Medical Applicationsmentioning

confidence: 99%

Nanocomposites for Additive Manufacturing

Redón¹,

Ruiz‐Huerta²,

Almanza-Arjona³

et al. 2017

AJCR

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“…These are based on injectable chemistries and made by using combining analogous matrices with cells/stem cells and biomolecules. 6 Injectable and biodegradable alginate-based composite gel scaffolds doubly integrated with hydroxyapatite (HAp) and gelatin microspheres (GMs) were cross-linked via in situ release of calcium cations. 6 Chitosan (CS) thermosensitive conductive hydrogels are also designed and generated with a highly porous network of interconnected pores.…”

Section: Introductionmentioning

confidence: 99%

“…6 Injectable and biodegradable alginate-based composite gel scaffolds doubly integrated with hydroxyapatite (HAp) and gelatin microspheres (GMs) were cross-linked via in situ release of calcium cations. 6 Chitosan (CS) thermosensitive conductive hydrogels are also designed and generated with a highly porous network of interconnected pores. 7 Similarly, thermosensitive chitosan/dextran-polylactide/glycerophosphate hydrogel as career for controllable release of bone morphogenetic protein-2 (BMP-2) are also generated.…”

Section: Introductionmentioning

confidence: 99%

Use of Polysaccharide Hydrogels in Drug Delivery and Tissue Engineering

Upadhyay¹

2017

ATROA

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Present review article aims to explain use of injectable hydrogels and microspheres derived from natural polysaccharides as drug delivery systems and cell scaffolds. Polysaccharides isolated from natural sources are proved much better than synthetic polymers for making single and composite hydrogels. This paper emphasizes recent developments occurred in use of amphiphilic polysaccharides for biomedical applications. It also explains use of various injectable polysaccharide structure-based hydrogels such as carboxymethyl chitin, hyaluronic acid, PTX-loaded modified hydrogels, Thermosensitive chitosan/dextran-polylactide/glycerophosphate hydrogel, Gellan Gum ,Chitin-CaSO4-nano-fibrin based injectable gel system, nanocomposite hydrogels, chondroitin Sulfate, photo-crosslinked gelatin methacrylate (GelMA) and thermosensitive chitosan/dextran-polylactide/glycerophosphate hydrogels and its functions in engineering cartilage tissue and injectable chemistries. More specifically, this paper high light use of combining analogous matrices with cells/stem cells and biomolecules and multi component approaches for making mimetic constructs. There is a need to develop more advanced designs of polysaccharide-based injectable hydrogels to widen the horizons of clinical drug delivery applications in biomedical engineering and several fields related to pharmaceutics.

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Injectable alginate/hydroxyapatite gel scaffold combined with gelatin microspheres for drug delivery and bone tissue engineering

Cited by 194 publications

References 36 publications

Cytocompatibility, biofilm assembly and corrosion behavior of Mg-HAP composites processed by extrusion

Cytocompatibility, biofilm assembly and corrosion behavior of Mg-HAP composites processed by extrusion

Nanocomposites for Additive Manufacturing

Use of Polysaccharide Hydrogels in Drug Delivery and Tissue Engineering

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