Injectable alginate-O-carboxymethyl chitosan/nano fibrin composite hydrogels for adipose tissue engineering

Jaikumar, Dhanya; Sajesh, K.M.; Sheela, S.; Nimal, T. R.; Chennazhi, K.P.; Nair, Shantikumar V.; Jayakumar, R.

doi:10.1016/j.ijbiomac.2014.12.037

Cited by 93 publications

(33 citation statements)

References 21 publications

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“…Furthermore, owing to its lack of cell adhesion ability, alginate is usually blended with other polymers. 143,144 An injectable, biodegradable, oxidized alginate/hyaluronic acid hydrogel has been prepared by Park and Lee. 143 At 6 weeks after injection of the hydrogel with primary chondrocytes into mice, effective cartilage regeneration has been observed.…”

Section: Injectable Hydrogels Prepared With Different Biomaterialsmentioning

confidence: 99%

“…In another study, a class of biocompatible and biodegradable alginate-based hydrogel blend has been synthesized by using alginate and O -carboxymethyl chitosan with the addition of fibrin nanoparticles. 144 Evaluation of the swelling ratio, degradation profile, compressive strength, and elastic module have indicated that alginate/ O -carboxymethyl chitosan forms a preferable blend for tissue-engineering applications.…”

Section: Injectable Hydrogels Prepared With Different Biomaterialsmentioning

confidence: 99%

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Injectable hydrogels for cartilage and bone tissue engineering

et al. 2017

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Tissue engineering has become a promising strategy for repairing damaged cartilage and bone tissue. Among the scaffolds for tissue-engineering applications, injectable hydrogels have demonstrated great potential for use as three-dimensional cell culture scaffolds in cartilage and bone tissue engineering, owing to their high water content, similarity to the natural extracellular matrix (ECM), porous framework for cell transplantation and proliferation, minimal invasive properties, and ability to match irregular defects. In this review, we describe the selection of appropriate biomaterials and fabrication methods to prepare novel injectable hydrogels for cartilage and bone tissue engineering. In addition, the biology of cartilage and the bony ECM is also summarized. Finally, future perspectives for injectable hydrogels in cartilage and bone tissue engineering are discussed.

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Section: Injectable Hydrogels Prepared With Different Biomaterialsmentioning

confidence: 99%

Section: Injectable Hydrogels Prepared With Different Biomaterialsmentioning

confidence: 99%

Injectable hydrogels for cartilage and bone tissue engineering

et al. 2017

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“…Jaikumar et al developed an injectable alginate-o-carboxymethyl chitosan/nanofibrin blended composite hydrogel as ADSC carrier. In vitro studies showed adherence, proliferation, and differentiation of the cells in the scaffold [145].…”

Section: Adipose Regenerative Engineeringmentioning

confidence: 99%

Chitosan Hydrogels for Regenerative Engineering

Padmanabhan

Nair

2015

Springer Series on Polymer and Composite Materials

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Research in the field of hydrogels has been actively growing for the past couple of decades. Hydrogels are crosslinked polymers with high water content. They can be prepared from natural, synthetic, and composite polymers using different chemical and physical crosslinking methods. Hydrogels have been widely explored for the delivery of bioactive molecules, drugs, and for other therapeutic applications. Chitosan-based hydrogels have unique advantages owing to their biocompatibility, biodegradability, antimicrobial activity, mucoadhesivity, and low toxicity. This chapter reviews the different methods used for preparing chitosan-based hydrogels and their applications as cell, protein, and drug delivery vehicles to support tissue regeneration.

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“…It is necessary to increase the cell adhesion rate in order to successfully load the desired cell and regenerate the tissue. Dhanya et al [33] made an attempt to prepare a scaffold for adipose tissue engineering by improving conventional alginate hydrogels. Although alginate hydrogels have been widely used as a biomaterial for tissue regeneration, lack of cell adhesion was the limitation for its clinical usage.…”

Section: Diversity Of Chitosan-based Local Drug Deliverymentioning

confidence: 99%

Chitosan-Based Multifunctional Platforms for Local Delivery of Therapeutics

et al. 2017

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Chitosan has been widely used as a key biomaterial for the development of drug delivery systems intended to be administered via oral and parenteral routes. In particular, chitosan-based microparticles are the most frequently employed delivery system, along with specialized systems such as hydrogels, nanoparticles and thin films. Based on the progress made in chitosan-based drug delivery systems, the usefulness of chitosan has further expanded to anti-cancer chemoembolization, tissue engineering, and stem cell research. For instance, chitosan has been used to develop embolic materials designed to efficiently occlude the blood vessels by which the oxygen and nutrients are supplied. Indeed, it has been reported to be a promising embolic material. For better anti-cancer effect, embolic materials that can locally release anti-cancer drugs were proposed. In addition, a complex of radioactive materials and chitosan to be locally injected into the liver has been investigated as an efficient therapeutic tool for hepatocellular carcinoma. In line with this, a number of attempts have been explored to use chitosan-based carriers for the delivery of various agents, especially to the site of interest. Thus, in this work, studies where chitosan-based drug delivery systems have successfully been used for local delivery will be presented along with future perspectives.

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Injectable alginate-O-carboxymethyl chitosan/nano fibrin composite hydrogels for adipose tissue engineering

Cited by 93 publications

References 21 publications

Injectable hydrogels for cartilage and bone tissue engineering

Injectable hydrogels for cartilage and bone tissue engineering

Chitosan Hydrogels for Regenerative Engineering

Chitosan-Based Multifunctional Platforms for Local Delivery of Therapeutics

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