Injectable amine functionalized graphene and chondroitin sulfate hydrogel with potential for cartilage regeneration

Tang, Caoxin; Holt, Brian D.; Wright, Zoe M.; Arnold, Anne M.; Moy, Alexandra C; Sydlik, Stefanie A.

doi:10.1039/c8tb02967a

Cited by 36 publications

(17 citation statements)

References 68 publications

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“…As the main component of our hydrogel, CS is capable of promoting cartilage regeneration. [18] Indeed, we found that the precursor solution exhibited the desirable syringeability owing to its low viscosity,w hich enabled the close filling of irregular defects.M oreover,c ascade enzyme complex polymerization endowed the hydrogel with ah igh mechanical strength, thereby rendering it suitable for use as af iller in cartilage repair. Considering the biosafety and mechanical properties of the hydrogel, 8wt% Acryloylated-CS and 3wt% DMAA were selected for further measurements.T he successful gelation of the CS-DMAA hydrogel was also observed in 100 %D ulbeccosM odified Eagle Medium and 20 %( v/v) mouse blood, where the hydrogel formed within 2min in the blood sample.…”

Section: Du ¼mentioning

confidence: 92%

Tissue Fluid Triggered Enzyme Polymerization for Ultrafast Gelation and Cartilage Repair

Zhang

et al. 2021

Angew Chem Int Ed

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The in situ gelation of injectable precursors is desirable in the field of tissue regeneration, especially in the context of irregular defect filling. The current driving forces for fast gelation include the phase-transition of thermally sensitive copolymers,c lick chemical reactions with tissue components, and metal coordination effect. However,the rapid formation of tough hydrogels remains ac hallenge.I nspired by aerobic metabolism, we herein propose atissue-fluid-triggered cascade enzymatic polymerization process catalyzedb yg lucose oxidase and ferrous glycinate for the ultrafast gelation of acryloylated chondroitin sulfates and acrylamides.T he highly efficient production of carbon radicals and macromolecules contribute to rapid polymerization for soft tissue augmentation in bone defects.T he copolymer hydrogel demonstrated the regeneration-promoting capacity of cartilage.A st he first example of using artificial enzyme complexes for in situ polymerization, this work offers abiomimetic approach to the design of strength-adjustable hydrogels for bio-implanting and bio-printing applications.

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Section: Du ¼mentioning

confidence: 92%

Tissue Fluid Triggered Enzyme Polymerization for Ultrafast Gelation and Cartilage Repair

Zhang

et al. 2021

Angew Chem Int Ed

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“…[ 136 ] In fact, GO can be added to various biomaterials such as silk fibroin hydrogel, chondroitin sulfate hydrogel, composite hydrogel of calcium alginate/PAM, and polycaprolactone scaffolds to improve mechanical behaviors and mimic natural cartilage. [ 137–140 ] Hybrid scaffold methacrylated chondroitin sulfate (CSMA)/poly(ethylene glycol) methyl ether‐ε‐caprolactone‐acryloyl chloride (PECA)/GO developed by Liao et al. [ 141 ] possessed good viscoelasticity, conductivity, as well as cartilage cell adhesion and proliferation in vitro and achieved the best reparative effect in an animal study to repair full‐thickness cartilage defect.…”

Section: Cartilage Repairmentioning

confidence: 99%

2D Nanomaterials for Tissue Engineering and Regenerative Nanomedicines: Recent Advances and Future Challenges

Zheng

Hong

Wang

et al. 2021

Adv Healthcare Materials

117

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Regenerative medicine has become one of the hottest research topics in medical science that provides a promising way for repairing tissue defects in the human body. Due to their excellent physicochemical properties, the application of 2D nanomaterials in regenerative medicine has gradually developed and has been attracting a wide range of research interests in recent years. In particular, graphene and its derivatives, black phosphorus, and transition metal dichalcogenides are applied in all the aspects of tissue engineering to replace or restore tissues. This review focuses on the latest advances in the application of 2D‐nanomaterial‐based hydrogels, nanosheets, or scaffolds that are engineered to repair skin, bone, and cartilage tissues. Reviews on other applications, including cardiac muscle regeneration, skeletal muscle repair, nerve regeneration, brain disease treatment, and spinal cord healing are also provided. The challenges and prospects of applications of 2D nanomaterials in regenerative medicine are discussed.

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“…This approach was demonstrated for hydrogels based on GO and either collagen [ 111 ] or poly-D,L-lactic acid/polyethylene glycol [ 112 ], designed to repair the cartilage. Chondroitin sulfate in another biomolecule of interest to promote regeneration of this tissue, and to this end it was crosslinked with a chemically modified GO, to yield a hydrogel that effectively stimulated the deposition of a collagen matrix from mesenchymal stem cells [ 113 ]. Hydroxyapatite is another useful component of natural origin to yield biomaterials to repair the cartilage, as shown for a hydrogel with GO and polyvinyl alcohol that was 3D printed and displayed excellent biomechanical and bio-friction properties [ 114 ].…”

Section: Recent Advancements On Hydrogels With Carbon Nanomaterials For Medicinementioning

confidence: 99%

Smart Hydrogels Meet Carbon Nanomaterials for New Frontiers in Medicine

2021

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Carbon nanomaterials include diverse structures and morphologies, such as fullerenes, nano-onions, nanodots, nanodiamonds, nanohorns, nanotubes, and graphene-based materials. They have attracted great interest in medicine for their high innovative potential, owing to their unique electronic and mechanical properties. In this review, we describe the most recent advancements in their inclusion in hydrogels to yield smart systems that can respond to a variety of stimuli. In particular, we focus on graphene and carbon nanotubes, for applications that span from sensing and wearable electronics to drug delivery and tissue engineering.

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Injectable amine functionalized graphene and chondroitin sulfate hydrogel with potential for cartilage regeneration

Abstract: Chemically functionalized graphene covalently reactsin situwith chondroitin sulfate to form an enhanced, injectable hydrogel for potential cartilage therapy.

Cited by 36 publications

References 68 publications

Tissue Fluid Triggered Enzyme Polymerization for Ultrafast Gelation and Cartilage Repair

Tissue Fluid Triggered Enzyme Polymerization for Ultrafast Gelation and Cartilage Repair

2D Nanomaterials for Tissue Engineering and Regenerative Nanomedicines: Recent Advances and Future Challenges

Smart Hydrogels Meet Carbon Nanomaterials for New Frontiers in Medicine

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