Injectable and self-healable nano-architectured hydrogel for NIR-light responsive chemo- and photothermal bacterial eradication

Rybak, Daniel; Rinoldi, Chiara; Nakielski, Paweł; Du, Jingtao; Haghighat Bayan, Mohammad Ali; Zargarian, Seyed Shahrooz; Pruchniewski, Michał; Li, Xiaoran; Strojny-Cieślak, Barbara; Ding, Bin; Pierini, Filippo

doi:10.1039/d3tb02693k

Cited by 23 publications

(9 citation statements)

References 96 publications

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“…Under the physiological conditions, SA maintained the solution state within the initial 12 h. With a prolonged time, the SA solution gradually gelatinized due to the strong ionic interaction and hydrophobic interaction, which can be applied for the injectable hydrogel. Rybak et al prepared a physical hybrid hydrogel using PF127 and calcium ion crosslinked alginate [ 82 ]. This hydrogel exhibited thermo-reversible characteristics, remaining in a liquid state at room temperature and transforming into a hydrogel in vivo after injection, due to the thermosensitivity of PF127.…”

Section: Synthesis Mechanisms Of Injectable Hydrogelsmentioning

confidence: 99%

Synthesis and Properties of Injectable Hydrogel for Tissue Filling

Xie,

Liu,

Wang

et al. 2024

Pharmaceutics

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Hydrogels with injectability have emerged as the focal point in tissue filling, owing to their unique properties, such as minimal adverse effects, faster recovery, good results, and negligible disruption to daily activities. These hydrogels could attain their injectability through chemical covalent crosslinking, physical crosslinking, or biological crosslinking. These reactions allow for the formation of reversible bonds or delayed gelatinization, ensuring a minimally invasive approach for tissue filling. Injectable hydrogels facilitate tissue augmentation and tissue regeneration by offering slow degradation, mechanical support, and the modulation of biological functions in host cells. This review summarizes the recent advancements in synthetic strategies for injectable hydrogels and introduces their application in tissue filling. Ultimately, we discuss the prospects and prevailing challenges in developing optimal injectable hydrogels for tissue augmentation, aiming to chart a course for future investigations.

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Section: Synthesis Mechanisms Of Injectable Hydrogelsmentioning

confidence: 99%

Synthesis and Properties of Injectable Hydrogel for Tissue Filling

Xie,

Liu,

Wang

et al. 2024

Pharmaceutics

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“…This hydrogel is perfect for use in drug administration and wound healing applications because of its high water absorption capability. PDA particles made it possible to inactivate Gram-positive and Gram-negative bacteria effectively, release medications on demand, and convert NIR light into localized heat Figure demonstrates some important natural polymers used in nanofiber synthesis, their modes of delivery, and their specific functions in the human body.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Electrospun Polymeric Nanofibers: Current Trends in Synthesis, Surface Modification, and Biomedical Applications

Yessuf,

Bahri,

Kassa

et al. 2024

ACS Appl. Bio Mater.

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Electrospun polymeric nanofibers are essential in various fields for various applications because of their unique properties. Their features are similar to extracellular matrices, which suggests them for applications in healthcare fields, such as antimicrobials, tissue engineering, drug delivery, wound healing, bone regeneration, and biosensors. This review focuses on the synthesis of electrospun polymeric nanofibers, their surface modification, and their biomedical applications. Nanofibers can be fabricated from both natural and synthetic polymers and their composites. Even though they mimic extracellular matrices, their surface features (physicochemical characteristics) are not always capable of fulfilling the purpose of the target application. Therefore, they need to be improved via surface modification techniques. Both needle-based and needleless electrospinning are thoroughly discussed. Various techniques and setups employed in each method are also reviewed. Furthermore, pre-and postspinning modification approaches for electrospun nanofibers, including instrument design and the modification features for targeted biomedical applications, are also extensively discussed. In this way, the remarkable potential of electrospun polymeric nanofibers can be highlighted to reveal future research directions in this dynamic field.

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“…Notably, photothermal therapy plays a crucial role in tumor treatment. 133,134 To maximize its potential, researchers are focused on developing nanoparticles that are sensitive to near-infrared light (NIR) and can induce immunogenic cell death. Nanoparticles such as carbon dots, Prussian blue, copper sulfide, manganese dioxide, and more have demonstrated significant therapeutic effects in animal experiments.…”

Section: Combination Therapymentioning

confidence: 99%