Injectable and self-healing dynamic hydrogel containing bioactive glass nanoparticles as a potential biomaterial for bone regeneration

Gantar, Ana; Drnovšek, Nataša; Casuso, Pablo; Vicente, Adrián Pérez-San; Rodríguez, Javier; Dupin, Damien; Novak, Saša; Loinaz, Iraida

doi:10.1039/c6ra17327f

Cited by 50 publications

(35 citation statements)

References 41 publications

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“…Soft CANs are excellent candidates as long‐term tissue replacements, as demonstrated by gold–thiolate and disulfide crosslinks in an artificial nucleus pulposus hydrogel that recapitulated of the biomechanical characteristics of healthy intervertebral discs 97. Additionally, similar CANs were used in a network containing agglomerates of bioactive glass nanoparticles as a scaffold for in situ bone regeneration 98. Other synthetic and natural polymers have been modified with dynamic imine and thiol–aldehyde crosslinks and supplemented with bioactive compounds, offering a variety of approaches to adaptable in vivo scaffolds for osteochondral defect repair and regeneration.…”

Section: Enabling Features and Emerging Applications Of Cansmentioning

confidence: 99%

Toward Stimuli‐Responsive Dynamic Thermosets through Continuous Development and Improvements in Covalent Adaptable Networks (CANs)

et al. 2020

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Covalent adaptable networks (CANs), unlike typical thermosets or other covalently crosslinked networks, possess a unique, often dormant ability to activate one or more forms of stimuli‐responsive, dynamic covalent chemistries as a means to transition their behavior from that of a viscoelastic solid to a material with fluid‐like plastic flow. Upon application of a stimulus, such as light or other irradiation, temperature, or even a distinct chemical signal, the CAN responds by transforming to a state of temporal plasticity through activation of either reversible addition or reversible bond exchange, either of which allows the material to essentially re‐equilibrate to an altered set of conditions that are distinct from those in which the original covalently crosslinked network is formed, often simultaneously enabling a new and distinct shape, function, and characteristics. As such, CANs span the divide between thermosets and thermoplastics, thus offering unprecedented possibilities for innovation in polymer and materials science. Without attempting to comprehensively review the literature, recent developments in CANs are discussed here with an emphasis on the most effective dynamic chemistries that render these materials to be stimuli responsive, enabling features that make CANs more broadly applicable.

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Section: Enabling Features and Emerging Applications Of Cansmentioning

confidence: 99%

Toward Stimuli‐Responsive Dynamic Thermosets through Continuous Development and Improvements in Covalent Adaptable Networks (CANs)

et al. 2020

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“…Ideally, an injectable hydrogel should perform as a low-viscosity liquid through application, but as an elastic solid when filling the defect with a fast conversion between both the states [43]. Viscoelasticity of the injectable hydrogels was evaluated using dynamic frequency test to measure the elastic (G ), viscous (G ) and complex shear (G * ) moduli, which are shown in figure 6.…”

Section: Viscoelastic Behaviour Studiesmentioning

confidence: 99%

Viscoelasticity, mechanical properties, and in vitro biodegradation of injectable chitosan-poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/nanohydroxyapatite composite hydrogel

El-Fattah

Mansour

2018

Bull Mater Sci

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A novel injectable composite hydrogel based on chitosan and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) reinforced with nanohydroxyapatite particles was synthesized. The chemical structure and morphology of the composite hydrogel were characterized. The composite hydrogel porosity, swelling, mechanical properties, viscoelasticity and in vitro biodegradation were also examined. Compared with the non-reinforced hydrogel, the composite hydrogel showed increased compressive strength, elastic modulus, viscous modulus, stiffness and had shear-thinning behaviour proving the injectability of the system. Swelling and biodegradation studies revealed that the composite scaffold possesses proper hydrophilicity and biodegradability. These properties make this composite hydrogel a promising injectable scaffold for bone regeneration.

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“…Hydrogel–Particle Mixtures : In addition to their use as colloidal building blocks or crosslinkers, nanoparticles can also be incorporated into polymeric hydrogels for mechanical reinforcement or other types of functionalization without affecting the self‐healing behavior of the polymeric hydrogel . This approach has been employed by Gantar et al to produce injectable and self‐healing gels for bone regeneration. This study showed that clusters of bioactive glass nanoparticles could effectively reinforce a dynamic hydrogel matrix composed of gold‐containing 4‐arm thiol‐terminated PEG, resulting in the formation of composite gels that were bioactive (apatite‐forming) and self‐healing.…”

Section: Intrinsic Self‐healing Biomaterialsmentioning

confidence: 99%

Self‐Healing Biomaterials: From Molecular Concepts to Clinical Applications

Diba

Spaans

Ning

et al. 2018

Adv Materials Inter

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were selected "off-the-shelf" based on the ingenuity of the surgeons. [1] During the last century, significant medical and technological progress has paved the way for the field of biomaterials research and the emergence of a biomaterials industry. Various synthetic or natural biomaterials have been developed which have enabled treatment of a wide range of medical conditions. Nevertheless, biomaterials are being considered for increasingly complex indications, which has increased the requirements for biomaterials considerably during the past decades. [2] Consequently, challenging-or even contradictorycombinations of biomaterial properties are often required which cannot be met by conventional biomaterials. For instance, biomaterials are desired which combine injectability, mechanical strength, and degradability with toughness to avoid mechanical damage following crack propagation. To meet these strict requirements, biomaterials are needed which can adapt to the implantation site and are able to heal themselves upon mechanical damage. While the majority of synthetic biomaterials does not recover from mechanical damage, natural tissues display a remarkable capacity for self-healing such as the spontaneous self-repair of bone fractures or ruptured skin. This self-healing ability is the ultimate solution of nature for continued survival based Biomaterials are being applied in increasingly complex areas such as tissue engineering, bioprinting, and regenerative medicine. For these applications, challenging-or even contradictory-combinations of biomaterial properties are often required which cannot be met by conventional biomaterials. During the past decade, several new concepts have been developed to render biomaterials self-healing, thereby offering new opportunities to improve the functionality of traditional biomaterials in terms of their mechanical, handling, and biological properties. Consequently, various types of self-healing polymeric, ceramic, or composite biomaterials have been developed. Nevertheless, despite the rapid emergence of the field of self-healing biomaterials, this field of research has not been reviewed during the recent years. Therefore, this article provides a critical overview of recent progress in the field of self-healing biomaterials research by discussing both extrinsic and intrinsic self-healing systems. While the extrinsic self-healing section focuses on self-healing dental materials and orthopedic bone cements that rely on release of healing liquids from embedded microcapsules, the section on intrinsic self-healing materials mainly discusses concepts for self-healing of polymeric biomaterials that are either hydrated (hydrogels) or nonhydrated (e.g., films and coatings). Finally, benefits of the self-healing feature for biomaterials are discussed, and directions for future research and developments are outlined.

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Injectable and self-healing dynamic hydrogel containing bioactive glass nanoparticles as a potential biomaterial for bone regeneration

Abstract: Combination of Au-based dynamic hydrogel with 100 nm bioactive glass nanoparticles resulted in the formation of an injectable, self-healing and biocompatible hydrogel nanocomposites with osteoinductive properties and potential for bone regeneration.

Cited by 50 publications

References 41 publications

Toward Stimuli‐Responsive Dynamic Thermosets through Continuous Development and Improvements in Covalent Adaptable Networks (CANs)

Toward Stimuli‐Responsive Dynamic Thermosets through Continuous Development and Improvements in Covalent Adaptable Networks (CANs)

Viscoelasticity, mechanical properties, and in vitro biodegradation of injectable chitosan-poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/nanohydroxyapatite composite hydrogel

Self‐Healing Biomaterials: From Molecular Concepts to Clinical Applications

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