Injectable, anti-inflammatory and conductive hydrogels based on graphene oxide and diacerein-terminated four-armed polyethylene glycol for spinal cord injury repair

Zhang, Kaijia; Li, Jiashuai; Jin, Jing; Dong, Jian; Li, Lan; Xue, Bin; Wang, Wei; Jiang, Qing; Cao, Yi

doi:10.1016/j.matdes.2020.109092

Cited by 62 publications

(45 citation statements)

References 61 publications

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“…Hydrogels are the most promising choice for the delivery of genes or cytokines for nerve proliferation and differentiation. The addition of GBMs to hydrogels has gained recent attention due to its desired resultant properties: (1) higher stability and controlled delivery of molecules, GO in particular; (2) overcoming the notable weak point of hydrogels, and low mechanical properties, by acting as a capable reinforcement; and (3) creating conductive hydrogels that are highly useful for mimicking the natural environment in the nervous tissues or organs [ 69 , 70 , 71 , 72 , 73 ].…”

Section: Tissue-engineered Scaffolds With Gbm and Neural Tissuesmentioning

confidence: 99%

Graphene-Based Materials Prove to Be a Promising Candidate for Nerve Regeneration Following Peripheral Nerve Injury

et al. 2021

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Peripheral nerve injury is a common medical condition that has a great impact on patient quality of life. Currently, surgical management is considered to be a gold standard first-line treatment; however, is often not successful and requires further surgical procedures. Commercially available FDA- and CE- approved decellularized nerve conduits offer considerable benefits to patients suffering from a completely transected nerve but they fail to support neural regeneration in gaps >30 mm. To address this unmet clinical need, current research is focused on biomaterial-based therapies to regenerate dysfunctional neural tissues, specifically damaged peripheral nerve, and spinal cord. Recently, attention has been paid to the capability of graphene-based materials (GBMs) to develop bifunctional scaffolds for promoting nerve regeneration, often via supporting enhanced neural differentiation. The unique features of GBMs have been applied to fabricate an electroactive conductive surface in order to direct stem cells and improve neural proliferation and differentiation. The use of GBMs for nerve tissue engineering (NTE) is considered an emerging technology bringing hope to peripheral nerve injury repair, with some products already in preclinical stages. This review assesses the last six years of research in the field of GBMs application in NTE, focusing on the fabrication and effects of GBMs for neurogenesis in various scaffold forms, including electrospun fibres, films, hydrogels, foams, 3D printing, and bioprinting.

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Section: Tissue-engineered Scaffolds With Gbm and Neural Tissuesmentioning

confidence: 99%

Graphene-Based Materials Prove to Be a Promising Candidate for Nerve Regeneration Following Peripheral Nerve Injury

et al. 2021

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“…Recently, a composite conductive hydrogel comprising amino-terminated 4-armed polyethylene glycol, diacerein and a GO nanosheet was developed. The conductive hydrogel had good injectability and demonstrated a therapeutic effect on a rat spinal cord injury model owing to conductivity from the GO nanosheet and an anti-inflammatory response from diacerein [ 79 ].…”

Section: Biomedical Applications Of Conductive Hydrogelmentioning

confidence: 99%

Design Strategies of Conductive Hydrogel for Biomedical Applications

Tsai

Hsu

2020

Molecules

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Conductive hydrogel, with electroconductive properties and high water content in a three-dimensional structure is prepared by incorporating conductive polymers, conductive nanoparticles, or other conductive elements, into hydrogel systems through various strategies. Conductive hydrogel has recently attracted extensive attention in the biomedical field. Using different conductivity strategies, conductive hydrogel can have adjustable physical and biochemical properties that suit different biomedical needs. The conductive hydrogel can serve as a scaffold with high swelling and stimulus responsiveness to support cell growth in vitro and to facilitate wound healing, drug delivery and tissue regeneration in vivo. Conductive hydrogel can also be used to detect biomolecules in the form of biosensors. In this review, we summarize the current design strategies of conductive hydrogel developed for applications in the biomedical field as well as the perspective approach for integration with biofabrication technologies.

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“…In self-healing and electrically conductive hydrogels, self-repairing behavior is not limited to restoring the mechanical property but also to restoring the electrical conductivity. Hydrogels that are conducting electricity showed an outstanding performance in bio-applications such as electro-stimulated drug delivery systems [ 38 , 39 , 40 ], biocompatible neural tissue engineering materials [ 41 , 42 ], and wearable strain sensors [ 43 ]. Moreover, it has been reported that electro-conductive self-healing hydrogels are able to completely restore the original mechanical strength after the healing process unlike other self-healing mechanisms [ 44 ].…”

Section: Introductionmentioning

confidence: 99%

Irreversible and Self-Healing Electrically Conductive Hydrogels Made of Bio-Based Polymers

Nada

Andicsová

Mosnáček

2022

IJMS

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Electrically conductive materials that are fabricated based on natural polymers have seen significant interest in numerous applications, especially when advanced properties such as self-healing are introduced. In this article review, the hydrogels that are based on natural polymers containing electrically conductive medium were covered, while both irreversible and reversible cross-links are presented. Among the conductive media, a special focus was put on conductive polymers, such as polyaniline, polypyrrole, polyacetylene, and polythiophenes, which can be potentially synthesized from renewable resources. Preparation methods of the conductive irreversible hydrogels that are based on these conductive polymers were reported observing their electrical conductivity values by Siemens per centimeter (S/cm). Additionally, the self-healing systems that were already applied or applicable in electrically conductive hydrogels that are based on natural polymers were presented and classified based on non-covalent or covalent cross-links. The real-time healing, mechanical stability, and electrically conductive values were highlighted.

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Injectable, anti-inflammatory and conductive hydrogels based on graphene oxide and diacerein-terminated four-armed polyethylene glycol for spinal cord injury repair

Cited by 62 publications

References 61 publications

Graphene-Based Materials Prove to Be a Promising Candidate for Nerve Regeneration Following Peripheral Nerve Injury

Graphene-Based Materials Prove to Be a Promising Candidate for Nerve Regeneration Following Peripheral Nerve Injury

Design Strategies of Conductive Hydrogel for Biomedical Applications

Irreversible and Self-Healing Electrically Conductive Hydrogels Made of Bio-Based Polymers

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