Injectable Aspirin as a Postoperative Analgesic

McAteer, E.; Dundee, John W.

doi:10.1093/bja/53.10.1069

Cited by 20 publications

(8 citation statements)

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“…(Kweekel-De Vries et al, 1974;Korttila, Pentti and Auvinen, 1980), and when given as a bolus i.v. (Blendinger and Eberlein, 1980;Tammisto and Tigerstedt, 1980;McAteer and Dundee, 1981). The results of these studies have been inconclusive with regard to the relative merit of LAS compared with opioid analgesics.…”

Section: Discussionmentioning

confidence: 99%

“…The results of these studies have been inconclusive with regard to the relative merit of LAS compared with opioid analgesics. Furthermore, intraoperative opioids were used in some of these studies (Kweekel-De Vries et al, 1974;McAteer and Dundee, 1981), and in one study LAS was not administered until at least 16 h after surgery (Blendinger and Eberlein, 1980). Intermittent injections of analgesics i.m., even when carried out at strictly regular intervals may be associated with poor control of pain after operation (Editorial, 1978;Austin, Stapleton and Mather, 1980a).…”

Section: Discussionmentioning

confidence: 99%

“…Lysine acetyl salicylate (LAS) is a water soluble salt of acetylsalicylic acid which may be given parenterally (LAS 1.8 g is equivalent to acetylsalicylic acid 1 g). The results of previous studies with LAS have been conflicting: some investigators suggest that its analgesic efficacy is comparable to that of opioids (Kweekel-De Vries et al, 1974;Blendinger and Eberlein, 1980;Korttila, Pentti and Auvinen, 1980), while others believe that, although LAS has some analgesic effect, it may not be comparable to opioids (McAteer and Dundee, 1981).…”

mentioning

confidence: 99%

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Comparison of Infusions of Morphine and Lysine Acetyl Salicylate for the Relief of Pain After Surgery

Cashman

Jones

Foster

et al. 1985

British Journal of Anaesthesia

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The effect of a constant i.v. infusion of lysine acetyl salicylate (LAS) on pain after operation was compared with that of a constant infusion of morphine in 30 patients undergoing unilateral inguinal herniorrhaphy. LAS provided analgesia equivalent to that provided by morphine and was associated with significantly less drowsiness, nausea and vomiting. No patient in either group was noted to suffer from respiratory depression. No untoward side effects were noted during or following the administration of LAS.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Comparison of Infusions of Morphine and Lysine Acetyl Salicylate for the Relief of Pain After Surgery

Cashman

Jones

Foster

et al. 1985

British Journal of Anaesthesia

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“…Its efficacy in the treatment of severe pain was shown in several clinical trials [1, 2, 3]. Despite being available for almost 20 years, intravenous LAS was only once evaluated in the treatment of acute migraine attacks [4].…”

Section: Introductionmentioning

confidence: 99%

Lysine-Acetylsalicylic Acid in Acute Migraine Attacks

Limmroth¹,

May²,

Diener³

1999

Eur Neurol

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Vasoconstrictive agents have been widely used in the treatment of migraine. These types of drugs have various side effects and are not suitable for many patients. Due to nausea or vomiting, nonoral treatment is often required, but only a few nonvasoconstrictive drugs exist in a parenteral form and are suitable for the treatment of acute migraine in the emergency setting. In a randomized, double-blind, crossover trial we evaluated the efficacy of 1,000 mg lysine-acetylsalicylic acid i.v. (LAS) compared to 0.5 mg ergotamine s.c. in 56 patients (112 attacks) with acute migraine. To gain further insight into the possible role of vasoconstriction, blood flow velocities (BFV) were measured in intra- and extracranial arteries using duplex sonography and transcranial Doppler sonography. Both agents were equally potent in relieving headache. Intravenous LAS resulted in a significantly faster relief and had fewer side effects. LAS had no effect on BFV. Ergotamine increased BFV in the middle cerebral artery only. No correlation was found between changes in BFV and the relief of headache. This is the first trial to compare the intravenous formulation of LAS in the treatment of migraine with another antimigraine medication and suggests that it is an effective and safe drug for the parenteral treatment of acute migraine attacks.

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“…Indometacin weniger verbreitet sind. Gemessen an Ätiologie und Ausmag der meisten Schmerzen in der frühen postoperativen Phase gelten die antipyretischen Analgetika im Rahmen einer Monotherapie jedoch als insgesamt zu schwach wirksam (29,44). Demgegenüber können sie nach kleineren (z.…”

Section: Pharmakologisch Unterscheidet Man Zwischen Drei Stoffklassenunclassified