Injectable Biomaterials for Dental Tissue Regeneration

Haugen, Håvard Jostein; Basu, Poulami; Sukul, Mousumi; Mano, João F.; Reseland, Janne Elin

doi:10.3390/ijms21103442

Cited by 61 publications

(53 citation statements)

References 220 publications

(278 reference statements)

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“…Chemical and bioactive traits of HA, such as the ability to bind water molecules or forming a framework for cell migration, provide a convenient environment for the seeded cells, while its conductive function facilitates ingrowth of the surrounding tissues [ 25 , 29 ]. The application of HA is broad, including bone, cartilage, skin, eye, periodontal, or dental pulp tissue engineering [ 30 , 31 , 32 , 33 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

Low Molecular Weight Hyaluronic Acid Effect on Dental Pulp Stem Cells In Vitro

et al. 2020

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Hyaluronic acid (HA) and dental pulp stem cells (DPSCs) are attractive research topics, and their combined use in the field of tissue engineering seems to be very promising. HA is a natural extracellular biopolymer found in various tissues, including dental pulp, and due to its biocompatibility and biodegradability, it is also a suitable scaffold material. However, low molecular weight (LMW) fragments, produced by enzymatic cleavage of HA, have different bioactive properties to high molecular weight (HMW) HA. Thus, the impact of HA must be assessed separately for each molecular weight fraction. In this study, we present the effect of three LMW-HA fragments (800, 1600, and 15,000 Da) on DPSCs in vitro. Discrete biological parameters such as DPSC viability, morphology, and cell surface marker expression were determined. Following treatment with LMW-HA, DPSCs initially presented with an acute reduction in proliferation (p < 0.0016) and soon recovered in subsequent passages. They displayed significant size reduction (p = 0.0078, p = 0.0019, p = 0.0098) while maintaining high expression of DPSC markers (CD29, CD44, CD73, CD90). However, in contrast to controls, a significant phenotypic shift (p < 0.05; CD29, CD34, CD90, CD106, CD117, CD146, CD166) of surface markers was observed. These findings provide a basis for further detailed investigations and present a strong argument for the importance of HA scaffold degradation kinetics analysis.

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Section: Introductionmentioning

confidence: 99%

Low Molecular Weight Hyaluronic Acid Effect on Dental Pulp Stem Cells In Vitro

et al. 2020

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“…Several scaffolds were investigated during the last two decades. Nowadays, the most studied scaffolds for periodontal application are hydrogels, films, fibers and 3D-printed scaffolds, realized using both synthetic and natural polymers ( Figure 1 ) [ 54 , 55 , 56 ].…”

Section: Main Scaffolds In Periodontal Tissue Regenerationmentioning

confidence: 99%

Influence of Materials Properties on Bio-Physical Features and Effectiveness of 3D-Scaffolds for Periodontal Regeneration

et al. 2021

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Periodontal diseases are multifactorial disorders, mainly due to severe infections and inflammation which affect the tissues (i.e., gum and dental bone) that support and surround the teeth. These pathologies are characterized by bleeding gums, pain, bad breath and, in more severe forms, can lead to the detachment of gum from teeth, causing their loss. To date it is estimated that severe periodontal diseases affect around 10% of the population worldwide thus making necessary the development of effective treatments able to both reduce the infections and inflammation in injured sites and improve the regeneration of damaged tissues. In this scenario, the use of 3D scaffolds can play a pivotal role by providing an effective platform for drugs, nanosystems, growth factors, stem cells, etc., improving the effectiveness of therapies and reducing their systemic side effects. The aim of this review is to describe the recent progress in periodontal regeneration, highlighting the influence of materials’ properties used to realize three-dimensional (3D)-scaffolds, their bio-physical characteristics and their ability to provide a biocompatible platform able to embed nanosystems.

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“…Sequentially, fibers have been deliberated for use in endodontic treatments/investigations. Haugen et al claim that nanofibers can be considered for pulp tissue engineering and regenerative endodontics due to their potential use for dental tissues [ 56 ]. Related studies have reported that fibers can act biomimetically to create microenvironments and behave as an appropriate scaffold for the pulp-dentine complex, mimicking the native pulp and function [ 57 ].…”

Section: Local Drug Delivery Systemsmentioning

confidence: 99%

Local Drug Delivery Systems for Vital Pulp Therapy: A New Hope

Parhizkar

Asgary

2021

International Journal of Biomaterials

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Vital pulp therapy (VPT) is deliberated as an ultraconservative/minimally invasive approach for the conservation of vital pulpal tissues, preservation of dental structure, and maintenance of tooth function in the oral cavity. In VPT, following the exposure of the dental pulp, the environment is prepared for the possible healing and probable refunctionalisation of pulpal connective tissue. However, to succeed in VPT, specific biomaterials are used to cover and/or dress the exposed pulp, lower the inflammation, heal the dental pulp, provoke the remaining odontoblastic cells, and induce the formation of a hard tissue, i.e., the dentinal bridge. It can be assumed that if the employed biomaterial is transferred to the target site using a specially designed micro-/nanosized local drug delivery system (LDDS), the biomaterial would be placed in closer proximity to the connective tissue, may be released in a controlled and sustained pattern, could properly conserve the remaining dental pulp and might appropriately enhance hard-tissue formation. Furthermore, the loaded LDDS could help VPT modalities to be more ultraconservative and may minimise the manipulation of the tooth structure as well as pulpal tissue, which could, in turn, result in better VPT outcomes.

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Injectable Biomaterials for Dental Tissue Regeneration

Cited by 61 publications

References 220 publications

Low Molecular Weight Hyaluronic Acid Effect on Dental Pulp Stem Cells In Vitro

Low Molecular Weight Hyaluronic Acid Effect on Dental Pulp Stem Cells In Vitro

Influence of Materials Properties on Bio-Physical Features and Effectiveness of 3D-Scaffolds for Periodontal Regeneration

Local Drug Delivery Systems for Vital Pulp Therapy: A New Hope

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