Injectable Bone Substitute Paste Based on Hydroxyapatite, Gelatin and Streptomycin for Spinal Tuberculosis

Maulida, Hendita Nur; Hikmawati, Dyah; Budiatin, Aniek Setiya

doi:10.4172/2165-7939.1000266

Cited by 17 publications

(27 citation statements)

References 6 publications

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“…The thoracolumbar junction is a weak biomechanical structure (Kim et al 2015;Maulida et al 2015;Shin et al 2016). This often leads to spinal instability that result in injuries, such as spine fractures and thoracolumbar junction syndrome.…”

Section: Introductionmentioning

confidence: 99%

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Differentiation and classification of thoracolumbar transitional vertebrae

2018

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The literature states that transitional vertebrae at any junction are characterized by features retained from two adjacent regions in the vertebral column. Currently, there is no published literature available that describes the prevalence or morphology of thoracolumbar transitional vertebrae (TLTV). The aim of this study was to identify the qualitative characteristics of transitional vertebrae at the thoracolumbar junction and establish a technique to differentiate the various subtypes that may be found. A selection of vertebral columns from skeletal remains (n = 35) were evaluated in this study. Vertebrae were taken based on features that are atypical for vertebrae in each relative region. The transitional vertebrae were qualitatively identified based on overlapping thoracic and lumbar features of vertebrae at the thoracolumbar junction. The following general overlapping characteristics were observed: aplasia or hypoplasia of the transverse process, irregular orientation on the superior articular process and atypical mammillary bodies. The results show that the most frequent location of the transitional vertebrae was in the thoracic region (f = 23). The second most frequent location was in the lumbar region (f = 10). In two specimens of the selection (f = 2), an additional 13th thoracic vertebra was present which functioned as a transitional vertebra. This study concluded that one can accurately identify the characteristics of transitional vertebrae at the thoracolumbar junction. In addition, the various subtypes can be differentiated according to the region in the vertebral column the vertebra is located in and the relative number of vertebral segments in the adjacent regions of the vertebral column. This provides a qualitative tool for researchers to differentiate the transitional vertebrae from distinctly different typical thoracic or lumbar vertebrae at the thoracolumbar junction.

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Section: Introductionmentioning

confidence: 99%

“…In addition, the majority (90%) of spine fractures are related to the thoracolumbar region. Severe instability, structural damage and post-traumatic deformity are the most frequent indications for surgical intervention (Beisse, 2006;Kim et al 2015;Maulida et al 2015;Shin et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Differentiation and classification of thoracolumbar transitional vertebrae

2018

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“…The marrow cavity is coated by a layer of thin vascularized connective tissue called the endosteum. Endosteum also has osteogenic cell as does the periosteum (Kalfas 2001, Kim et al 2004, Maulida et al 2015.…”

Section: Discussionmentioning

confidence: 99%

Acceleration of Bone Fracture Healing through the Use of Natural Bovine Hydroxyapatite Implant on Bone Defect Animal Model

Khotib

Lasandara

Samirah

et al. 2019

FMI

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Bone is an important organ for supports the body that stores reserve of calcium, phosphorus, and other minerals. In fracture conditions where bleeding, soft tissue edema, nerve damage, and blood vessels around the bone damage happen, they can cause the mobilization of these minerals in the surrounding tissue. One of the efforts made in the treatment of these fractures is reconnection, in which it works by filling of bone defect with a matrix and administration of anti-infection. Biomaterial filling in defective bone is thought to accelerate the healing process of bone fracture and prevent osteomyelitis. For this reason, this study evaluates the acceleration of bone fracture healing using natural hydroxyapatite (NHA) bone filler in rabbits with bone defect model. Fracture modeling was performed by surgical technique and drilling of bones with a 4.2 mm diameter to form a defect in the rabbit femur. Bone implant contained bovine hydroxyapatite-gelatin-glutaraldehyde (BHA implant) or bovine hydroxyapatite-gelatin-glutaraldehyde-gentamicin (BHA-GEN implant) that was inserted in bone defects. 27 rabbits were divided into 3 groups: the control group who had bone defect, the bone defect group was given BHA implant and the bone defect group was given BHA-GEN implant. Observation of osteoclast, osteoblast, osteocyte, BALP level, and bone morphological integrity was carried out on the 14th, 28th, and 42nd days after surgery. Histological observation of rabbit femur showed a significant difference on the number of osteoclast, osteoblast and osteocyte in all three groups. The BALP level also showed a significant difference in the group given the natural BHA bone implant compared to the control group on day 14 (p = 0.0361). Based on the result of the X-ray, there was also a better integration of rabbit femur bone in groups with the use of BHA or BHA-GEN bone implant. Thus, it can be concluded that the use of a natural BHA implant can accelerate the process of bone repair in the fracture of rabbit femur. In addition, BHA implants were compatible as a matrix for supporting the bone cell growth.

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“…, ; Maulida et al. ). This explains the repercussions that anatomical variation may have on weight transfer of the spine.…”

Section: Lumbosacral Transitional Vertebra Frequency Tablementioning

confidence: 99%