Injectable chitosan/gelatin/bioactive glass nanocomposite hydrogels for potential bone regeneration: In vitro and in vivo analyses

Moreira, Cheisy D.F.; Carvalho, Sandhra M.; Florentino, Rodrigo M.; França, Andressa; Okano, Bárbara Silva; Rezende, C.M.F.; Mansur, Alexandra A.P.; Pereira, Marivalda M.

doi:10.1016/j.ijbiomac.2019.03.237

Cited by 63 publications

(27 citation statements)

References 40 publications

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“…in the morphology of subcutaneous tissue or on liver function. Implantation of bioactive glass containing hydrogels into tibial metaphyseal bone defects in Swiss rats did not demonstrate a significant change in typical X-ray micro-computed tomography-based bone morphometric parameters compared to unfilled defects [34].…”

Section: Collagen Gelatin Cellulose Chitosan and Other Biopolymersmentioning

confidence: 75%

“…During the last three years, a multitude of combinations of bioactive glass/glass-ceramic with other naturalderived or synthetic 'biomaterials' have been developed and investigated in vivo. While rats and rabbits are commonly used, experimental models in mice [34,41], dog [17,35], sheep [66] , and goat [54] are less frequently employed. Compositions such as Bioglass® 45S5, S53P4, and borate glasses are among the most popular and promising compositions.…”

Section: Discussionmentioning

confidence: 99%

“…The most frequently used methods for this purpose have included histological and morphological assessment, immunohistochemical analyses, and 3D visualization using X-ray micro-computed tomography in order to determine bone morphometric parameters such as bone volume, bone mineral density, trabecular thickness, and trabecular separation etc. [34,67,80]. Additionally, the degradation behavior has been identified as an important factor contributing to the rate of osteogenesis or new bone volume [18,81].…”

Section: Discussionmentioning

confidence: 99%

“…In a comparison of degradation kinetics under different loading conditions, it has been observed that mechanical loading may enhance the rate of degradation [78]. Results from studies reporting either enhanced osteogenesis (or greater bone formation) [32] or lack of a significant difference [34], in comparison to untreated or unfilled defects should be interpreted cautiously, since this tends to present a partially biased view of the biological/osteogenic response.…”

Section: Discussionmentioning

confidence: 99%

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In Vivo Behavior of Bioactive Glass-Based Hybrids in Animal Models For Bone Regeneration

Shal¹

2020

Preprint

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This review presents the recent advances and the current state-of-the-art of bioactive glass-based hybrid biomaterials for bone regeneration. Hybrid materials comprise two (or more) constituents at the nanometre scale, in which typically, one constituent is organic and functions as the matrix phase and the other constituent is inorganic and behaves as the filler phase. Such materials, thereby, more closely resemble natural bio-nanocomposites such as bone. Various glass compositions in combination with a wide range of natural and synthetic polymers have been evaluated in vivo under experimental conditions ranging from unloaded critical-sized defects to mechanically-loaded, weight-bearing sites with highly favourable outcomes. Additional possibilities include controlled release of anti-osteoporotic drugs, ions, antibiotics, pro-angiogenic substances and pro-osteogenic substances. Histological and morphological evaluations suggest the formation of new, highly vascularised bone that displays signs of remodelling over time. With the possibility to tailor the mechanical and chemical properties through careful selection of individual components, as well as the overall geometry (from mesoporous particles and micro-/nanospheres to 3D scaffolds and coatings) through innovative manufacturing processes, such biomaterials present exciting new avenues for bone repair and regeneration.

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Section: Collagen Gelatin Cellulose Chitosan and Other Biopolymersmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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In Vivo Behavior of Bioactive Glass-Based Hybrids in Animal Models For Bone Regeneration

Shal¹

2020

Preprint

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“…Composite hydrogels delivered the antibiotic drugs for 3 days and induced the cell differentiation and osteoblasts proliferation, benefiting for bone tissue formations using the osteomyelitis-induced animal model. Moreira et al (2018 , 2019) constructed a novel thermo-responsive CS/gelatin/nBG-based composite hydrogel by combining CS-gelatin with bioactive glass NP (nBG), on account of its capacity to bond with living tissues, these thermo-responsive composite hydrogels possessed enhanced osteoblasts proliferation and angiogenesis-related gene expressions, thus promoting cell proliferation activity and bone regeneration. Additionally, introducing metallic NPs into injectable hydrogels can facilitate bone cell growth and expand bone regeneration applications.…”

Section: Cs-based Hydrogelsmentioning

confidence: 99%

Recent Advances of Chitosan-Based Injectable Hydrogels for Bone and Dental Tissue Regeneration

Tang

Tan

Zeng

et al. 2020

Front. Bioeng. Biotechnol.

113

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Traditional strategies of bone repair include autografts, allografts and surgical reconstructions, but they may bring about potential hazard of donor site morbidity, rejection, risk of disease transmission and repetitive surgery. Bone tissue engineering (BTE) is a multidisciplinary field that offers promising substitutes in biopharmaceutical applications, and chitosan (CS)-based bone reconstructions can be a potential candidate in regenerative tissue fields owing to its low immunogenicity, biodegradability, bioresorbable features, low-cost and economic nature. Formulations of CS-based injectable hydrogels with thermo/pH-response are advantageous in terms of their highwater imbibing capability, minimal invasiveness, porous networks, and ability to mold perfectly into an irregular defect. Additionally, CS combined with other naturally-derived or synthetic polymers and bioactive agents has proven to be an effective alternative to autologous bone and dental grafts. In this review, we will highlight the current progress in the development of preparation methods, physicochemical properties and applications of CS-based injectable hydrogels and their perspectives in bone and dental regeneration. We believe this review is intended as starting point and inspiration for future research effort to develop the next generation of tissue-engineering scaffold materials.

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Fabrication of Bioactive Structures from Sol–Gel Derived Bioactive Glass

Durgalakshmi¹,

Kumar²

2022

Bioactive Glasses and Glass‐Ceramics

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Injectable chitosan/gelatin/bioactive glass nanocomposite hydrogels for potential bone regeneration: In vitro and in vivo analyses

Cited by 63 publications

References 40 publications

In Vivo Behavior of Bioactive Glass-Based Hybrids in Animal Models For Bone Regeneration

In Vivo Behavior of Bioactive Glass-Based Hybrids in Animal Models For Bone Regeneration

Recent Advances of Chitosan-Based Injectable Hydrogels for Bone and Dental Tissue Regeneration

Fabrication of Bioactive Structures from Sol–Gel Derived Bioactive Glass

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