Injectable chitosan hydrogel embedding modified halloysite nanotubes for bone tissue engineering

Kazemi-Aghdam, Fereshteh; Jahed, Vahid; Dehghan-Niri, Maryam; Ganji, Fariba; Vasheghani‐Farahani, Ebrahim

doi:10.1016/j.carbpol.2021.118311

Cited by 79 publications

(46 citation statements)

References 36 publications

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“…Another study with thermosensitive methylcellulose (MC) hydrogels containing bassorin (Ba) and halloysite nanotubes (HNTs) achieved excellent proliferation, differentiation, cellular mineralization, and bone cell-specific gene expression [ 3 ]. A study produced nanocomposite hydrogels of chitosan, modified halloysite nanotubes, and icariin, and found that the biocompatibility improved the in vivo bone formation and the differentiation of encapsulated cells [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Nanocomposite Hydrogel Produced from PEGDA and Laponite for Bone Regeneration

Magalhães

Andrade

Bezerra

et al. 2022

JFB

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Herein, a nanocomposite hydrogel was produced using laponite and polyethylene-glycol diacrylate (PEGDA), with or without Irgacure (IG), for application in bone tissue regeneration. The nanocomposites were characterized by X-ray diffraction (XRD), Fourier-Transform infrared spectroscopy (FTIR), and thermal analysis (TG/DTG). The XRD results showed that the crystallographic structure of laponite was preserved in the nanocomposite hydrogels after the incorporation of PEGDA and IG. The FTIR results indicated that PEGDA polymer chains were entangled on laponite in hydrogels. The TG/DTG found that the presence of laponite (Lap) improved the thermal stability of nanocomposite hydrogel. The toxicity tests by Artemia salina indicated that the nanocomposite hydrogels were not toxic, because the amount of live nauplii was 80.0%. In addition, in vivo tests demonstrated that the hydrogels had the ability to regenerate bone in a bone defect model of the tibiae of osteopenic rats. For the nanocomposite hydrogel (PEGDA + Lap nanocomposites + UV light), the formation of intramembranous bone in the soft callus was more intense in 66.7% of the animals. Thus, the results presented in this study evidence that nanocomposite hydrogels obtained from laponite and PEGDA have the potential for use in bone regeneration.

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Section: Introductionmentioning

confidence: 99%

Nanocomposite Hydrogel Produced from PEGDA and Laponite for Bone Regeneration

Magalhães

Andrade

Bezerra

et al. 2022

JFB

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“…There are numerous protocols for the preparation of modified and hybrid CS scaffolds, which attract huge interest, particularly in BTE [ 98 , 99 , 100 ]. Among different methods of modified CS, cross-linking, structure modifications, and grafts with biodegradable polymer are the basic approaches to producing BTE scaffolds.…”

Section: Modification Methods Of Chitosan For Btementioning

confidence: 99%

“…This is an attractive option for BTE due to boosting the mechanical properties of polymer matrix resulting from their high aspect ratio and tough structure and the absorbable degradation products that induce osteogenic cell differentiation [ 247 ]. Several studies have proved the favorable biological properties of the scaffolds and hydrogels consisting of CS and HNTs [ 98 , 248 , 249 ]. Liu et al combined solution-mixing and freeze-drying techniques to develop novel CS/HNT nanocomposite (NC) scaffolds [ 250 ].…”

Section: Application Of Structure-modified Chitosan For Btementioning

confidence: 99%

Application Progress of Modified Chitosan and Its Composite Biomaterials for Bone Tissue Engineering

Zhu

Zhang

Zhou

2022

IJMS

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In recent years, bone tissue engineering (BTE), as a multidisciplinary field, has shown considerable promise in replacing traditional treatment modalities (i.e., autografts, allografts, and xenografts). Since bone is such a complex and dynamic structure, the construction of bone tissue composite materials has become an attractive strategy to guide bone growth and regeneration. Chitosan and its derivatives have been promising vehicles for BTE owing to their unique physical and chemical properties. With intrinsic physicochemical characteristics and closeness to the extracellular matrix of bones, chitosan-based composite scaffolds have been proved to be a promising candidate for providing successful bone regeneration and defect repair capacity. Advances in chitosan-based scaffolds for BTE have produced efficient and efficacious bio-properties via material structural design and different modifications. Efforts have been put into the modification of chitosan to overcome its limitations, including insolubility in water, faster depolymerization in the body, and blood incompatibility. Herein, we discuss the various modification methods of chitosan that expand its fields of application, which would pave the way for future applied research in biomedical innovation and regenerative medicine.

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“…Kazemi-Aghdam and co-workers developed an injectable chitosanmodified halloysite nanotubes hydrogel with enhanced mechanical strength and improved osteoinductivity for bone tissue engineering. Interestingly, they encapsulated MSCs into the hydrogels, resulting in enhanced cell proliferation and bone differentiation [23]. Huang et al also investigated a hydrogel incorporated with halloysite nanotubes fabricated by using the photopolymerization method for potential bone tissue engineering applications.…”

Section: Orthopaedic Applicationsmentioning

confidence: 99%

Inorganic Nanomaterials in Tissue Engineering

et al. 2022

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In recent decades, the demand for replacement of damaged or broken tissues has increased; this poses the attention on problems related to low donor availability. For this reason, researchers focused their attention on the field of tissue engineering, which allows the development of scaffolds able to mimic the tissues’ extracellular matrix. However, tissue replacement and regeneration are complex since scaffolds need to guarantee an adequate hierarchical structured morphology as well as adequate mechanical, chemical, and physical properties to stand the stresses and enhance the new tissue formation. For this purpose, the use of inorganic materials as fillers for the scaffolds has gained great interest in tissue engineering applications, due to their wide range of physicochemical properties as well as their capability to induce biological responses. However, some issues still need to be faced to improve their efficacy. This review focuses on the description of the most effective inorganic nanomaterials (clays, nano-based nanomaterials, metal oxides, metallic nanoparticles) used in tissue engineering and their properties. Particular attention has been devoted to their combination with scaffolds in a wide range of applications. In particular, skin, orthopaedic, and neural tissue engineering have been considered.

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Injectable chitosan hydrogel embedding modified halloysite nanotubes for bone tissue engineering

Cited by 79 publications

References 36 publications

Nanocomposite Hydrogel Produced from PEGDA and Laponite for Bone Regeneration

Nanocomposite Hydrogel Produced from PEGDA and Laponite for Bone Regeneration

Application Progress of Modified Chitosan and Its Composite Biomaterials for Bone Tissue Engineering

Inorganic Nanomaterials in Tissue Engineering

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