Injectable chondroitin sulfate-grafted self-antioxidant hydrogels ameliorate nucleus pulposus degeneration against overactive inflammation

Luo, Huitong; Wang, Zetao; He, Zhichao; Ling, Zemin; Wang, Hao; Zhu, Jiayi; Nie, Jing‐Jun; Chen, Dafu; Qi, Feng; Cao, Xiaodong

doi:10.1039/d3bm00359k

Cited by 12 publications

(4 citation statements)

References 65 publications

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“…Inflammation is a complex biological process occurring in response to harmful stimuli causing injury to healthy tissue. Oxidative stress resulting from a high level of ROS is one of the key contributors to inflammation [ 92 – 93 ]. Therefore, balancing the ROS level via antioxidant supplementation is a promising strategy for treating inflammatory diseases.…”

Section: Reviewmentioning

confidence: 99%

“…Inflammation is a complex biological process occurring in response to harmful stimuli causing injury to healthy tissue. Oxidative stress resulting from a high level of ROS is one of the key contributors to inflammation [92,93] To increase the targeting ability, anti-inflammatory agents can be wrapped with a cell membrane camouflage technique [99][100][101]. For example, Ma et al constructed carbon dot-SOD nanozymes and CD98 CRISPR/Cas9 plasmids encapsulated in a metal-organic framework (MOF), and then camouflaged it with macrophage membrane [102].…”

Section: Inflammatory Diseasesmentioning

confidence: 99%

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Classification and application of metal-based nanoantioxidants in medicine and healthcare

Nam,

Tran,

Nguyen

et al. 2024

Beilstein J. Nanotechnol.

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Antioxidants play an important role in the prevention of oxidative stress and have been widely used in medicine and healthcare. However, natural antioxidants have several limitations such as low stability, difficult long-term storage, and high cost of large-scale production. Along with significant advances in nanotechnology, nanomaterials have emerged as a promising solution to improve the limitations of natural antioxidants because of their high stability, easy storage, time effectiveness, and low cost. Among various types of nanomaterials exhibiting antioxidant activity, metal-based nanoantioxidants show excellent reactivity because of the presence of an unpaired electron in their atomic structure. In this review, we summarize some novel metal-based nanoantioxidants and classify them into two main categories, namely chain-breaking and preventive antioxidant nanomaterials. In addition, the applications of antioxidant nanomaterials in medicine and healthcare are also discussed. This review provides a deeper understanding of the mechanisms of metal-based nanoantioxidants and a guideline for using these nanomaterials in medicine and healthcare.

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“…Inflammation is a complex biological process occurring in response to harmful stimuli causing injury to healthy tissue. Oxidative stress resulting from a high level of ROS is one of the key contributors to inflammation [ 92 – 93 ]. Therefore, balancing the ROS level via antioxidant supplementation is a promising strategy for treating inflammatory diseases.…”

Section: Reviewmentioning

confidence: 99%

“…Inflammation is a complex biological process occurring in response to harmful stimuli causing injury to healthy tissue. Oxidative stress resulting from a high level of ROS is one of the key contributors to inflammation [92,93] To increase the targeting ability, anti-inflammatory agents can be wrapped with a cell membrane camouflage technique [99][100][101]. For example, Ma et al constructed carbon dot-SOD nanozymes and CD98 CRISPR/Cas9 plasmids encapsulated in a metal-organic framework (MOF), and then camouflaged it with macrophage membrane [102].…”

Section: Inflammatory Diseasesmentioning

confidence: 99%

Classification and application of metal-based nanoantioxidants in medicine and healthcare

Nam,

Tran,

Nguyen

et al. 2024

Beilstein J. Nanotechnol.

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“…It demonstrated significant potential in regulating the balance of ECM metabolism within an abnormal microenvironment. Luo et al 101 demonstrated effective sustained delivery of chondroitin sulfate (CS). This hydrogel was found to successfully inhibit the expression of inflammatory cytokines and maintain a balance between anabolic and catabolic processes in an inflammation-simulated environment.…”

Section: Major Categories Of Ndds For Ivddmentioning

confidence: 99%

“… Chang et al 98 2022 Polymeric micelles Runx1 Rats In situ injection Increased hydration content, disc space height and ECM production. Chang et al 100 2022 Nanohydrogels circSTC2 Rats In situ injection Promoted ECM synthesis and repaired NP tissue Luo et al 101 2023 Nanohydrogels Chondroitin sulfate Rats In situ injection Anti-inflammation. …”

Section: Major Categories Of Ndds For Ivddmentioning

confidence: 99%

The Emerging Roles of Nanocarrier Drug Delivery System in Treatment of Intervertebral Disc Degeneration-Current Knowledge, Hot Spots, Challenges and Future Perspectives

Hu,

Yang,

Liu

et al. 2024

DDDT

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Low back pain (LBP) is a common condition that has substantial consequences on individuals and society, both socially and economically. The primary contributor to LBP is often identified as intervertebral disc degeneration (IVDD), which worsens and leads to significant spinal problems. The conventional treatment approach for IVDD involves physiotherapy, drug therapy for pain management, and, in severe cases, surgery. However, none of these treatments address the underlying cause of the condition, meaning that they cannot fundamentally reverse IVDD or restore the mechanical function of the spine. Nanotechnology and regenerative medicine have made significant advancements in the field of healthcare, particularly in the area of nanodrug delivery systems (NDDSs). These approaches have demonstrated significant potential in enhancing the efficacy of IVDD treatments by providing benefits such as high biocompatibility, biodegradability, precise drug delivery to targeted areas, prolonged drug release, and improved therapeutic results. The advancements in different NDDSs designed for delivering various genes, cells, proteins and therapeutic drugs have opened up new opportunities for effectively addressing IVDD. This comprehensive review provides a consolidated overview of the recent advancements in the use of NDDSs for the treatment of IVDD. It emphasizes the potential of these systems in overcoming the challenges associated with this condition. Meanwhile, the insights and ideas presented in this review aim to contribute to the advancement of precise IVDD treatment using NDDSs.

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Injectable and Microporous Microgel Assembly with Sequential Bioactive Factor Release for the Endogenous Repair of Nucleus Pulposus

Luo,

Wang,

et al. 2024

Adv Funct Materials

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Harnessing endogenous stem/progenitor cells to enhance extracellular matrix (ECM) deposition in the nucleus pulposus (NP) is considered as a potential treatment for intervertebral disc degeneration (IVDD), but is limited by the lack of suitable scaffolds for cell infiltration and growth, as well as the tailored release of bioactive factors. Herein, an injectable cell‐free microgel assembly (MA‐TNS) with interconnected microporous structure is developed to recruit stem/progenitor cells and induce the differentiation of the recruited cells by releasing stromal cell‐derived factor‐1α (SDF‐1α) and transforming growth factor‐β1 (TGF‐β1) sequentially. TGF‐β1 is initially loaded by the chondroitin sulfate/gelatin nanoparticles. Together with SDF‐1α, these nanoparticles are co‐encapsulated into the photo‐cross‐linked microgels, which are then assembled into a microporous scaffold via dynamic boronate ester bonds. An initial rapid release of SDF‐1α followed by a sustained release of TGF‐β1 lasting over 28 days is achieved. MA‐TNS significantly promotes the recruitment, infiltration, and chondrocyte‐like differentiation of marrow mesenchymal stem cells in vitro. Furthermore, in vivo experiments on rats and cynomolgus monkeys prove that MA‐TNS can inhibit IVDD and recover ECM deposition markedly, thereby enabling long‐term NP reconstruction. The resulting efficacy in rats and nonhuman primates supports that MA‐TNS is a promising scaffold for intervertebral disc repair and regeneration.

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Injectable chondroitin sulfate-grafted self-antioxidant hydrogels ameliorate nucleus pulposus degeneration against overactive inflammation

Abstract: Overactive inflammatory cascade accompanied with oxidative stress in nucleus pulposus exacerbates intervertebral disc degeneration (IVDD). Hydrogels have been demonstrated promising in treating IVDD, yet remains less efficacious in anti-inflammation supplemented...

Cited by 12 publications

References 65 publications

Classification and application of metal-based nanoantioxidants in medicine and healthcare

Classification and application of metal-based nanoantioxidants in medicine and healthcare

The Emerging Roles of Nanocarrier Drug Delivery System in Treatment of Intervertebral Disc Degeneration-Current Knowledge, Hot Spots, Challenges and Future Perspectives

Injectable and Microporous Microgel Assembly with Sequential Bioactive Factor Release for the Endogenous Repair of Nucleus Pulposus

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