Injectable Collagen/CMC Soft Tissue Filler with Developed Flow Properties

Abstract

Based on the remarkable demand for facial reconstitute or reshape fillers due to the dermal defects arising from specific diseases, trauma, or aging, several natural or synthetic materials have been investigated. Among the evaluated materials, decellularized dermis is one of the most biocompatible choices for the aim of skin tissue regenerative approaches. On the other hand, Carboxymethyl Cellulose (CMC), a synthetic polysaccharide, with the desirable degradability, biomechanical stability, and nontoxicity seems to be an acceptable reinforcement agent for decellularized dermis. Thus, in this research, an injectable soft tissue filler contained of human-derived decellularized collagen and CMC was fabricated. The cell-removal approving was performed utilizing H&E staining assay. The biocompatibility of the prepared samples was confirmed by MTT assay. The rheology examination demonstrated the increased storage modulus and enhanced elastic property as a consequence of CMC presence. Furthermore, the required flow force of the collagen/CMC filler was decreased as a consequence of decreasing the viscosity and its injectability was improved. According to the provided biomechanical and biological results, it could be claimed that the collagen/CMC hydrogel is a suitable substitute filler for skin tissue engineering.

Computational Biomechanics and Machine Learning: Charting the Future of Molecular and Cellular Biomechanics Field

“…The 2022 volume also highlighted Samanipour et al's [10] exploration of decellularized collagen and Carboxymethyl Cellulose (CMC) as an injectable soft tissue filler, demonstrating biomechanics' potential contributions to skin tissue regeneration. In the realm of dental biomechanics, Xu et al [11] utilized a computational approach to analyze stress distribution in dental implants, contributing valuable insights to the field of prosthetic dentistry.…”

Hot Topics of Molecular and Cellular Biomechanics in 2022

“…Due to the reduction in collagen and fat in the dermis caused by aging, trauma, and disease, it is widely needed as an injection filler for soft tissue enhancement. Samanipour et al [18] prepared an injectable soft tissue filler containing human acellular collagen and carboxymethyl cellulose (CMC). According to the provided biomechanical and biological results, it can be claimed that collagen/CMC hydrogel is a suitable alternative filler for skin tissue engineering.…”