Injectable, compression‐resistant polymer/ceramic composite bone grafts promote lateral ridge augmentation without protective mesh in a canine model

Talley, Anne D.; Boller, Lauren A.; Kalpakci, Kerem N.; Shimko, Daniel A.; Cochran, David L.; Guelcher, Scott A.

doi:10.1111/clr.13257

Cited by 8 publications

(12 citation statements)

References 41 publications

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“…These evidence the process of biodegradation of the implant and suggest adequate biocompatibility of the material. The use of bioceramics tends to promote a more discreet bone neoformation, which may explain the discrete periosteal reaction observed in a single animal in the present study (Talley et al, 2018).…”

Section: Radiographs Of the Scaffolds After Implantationmentioning

confidence: 58%

Synthesis and in vivo evaluation of a scaffold containing wollastonite/β‐TCP for bone repair in a rabbit tibial defect model

et al. 2019

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Scaffolds are models designed to aid the interaction between cells and extracellular bone matrix, providing structural support for newly formed bone tissue. In this work, wollastonite with β‐TCP porous ceramic scaffolds was developed by the polymer sponge replication. Their microstructure, cell viability and bioactivity were tested. in vivo was performed to evaluate the use of a calcium silicate‐based implant in the repair of rabbit tibias. Holes were made in the both proximal and distal tibial metaphysis of each animal and filled with calcium silicate‐based implant, and in the left tibia, no implant were used, serving as control group. Animals underwent euthanasia after 30 and 60 days of study. The animals were submitted to clinical‐radiographic evaluations and their histology was analyzed by optical and scanning electron microscope. The studied calcium silicate implant provided biocompatibility and promoted bone formation, stimulating the process of bone repair in rabbits, features observed by gradual radiopacity shown in the radiographic evaluations.

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Section: Radiographs Of the Scaffolds After Implantationmentioning

confidence: 58%

Synthesis and in vivo evaluation of a scaffold containing wollastonite/β‐TCP for bone repair in a rabbit tibial defect model

et al. 2019

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“…PUR foams augmented with recombinant human bone morphogenetic protein (rhBMP-2) have been reported to support the regeneration of bone tissue (34,35). While these foams degrade after 8 to 16 weeks in vivo (36,37), our results suggest that even resorbable drug delivery platforms such as PUR foams can harbor significant numbers of bacteria during acute infection. Antibiotic-loaded PUR foams have been shown to decrease bacterial burdens (7,26); however, tuning the release kinetics to deliver an effective dose for a sustained time period remains a major limitation.…”

Section: Discussionmentioning

confidence: 68%

Concurrent Local Delivery of Diflunisal Limits Bone Destruction but Fails To Improve Systemic Vancomycin Efficacy during Staphylococcus aureus Osteomyelitis

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et al. 2020

Antimicrob Agents Chemother

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Staphylococcus aureus osteomyelitis is a debilitating infection of bone. Treatment of osteomyelitis is impaired by the propensity of invading bacteria to induce pathological bone remodeling that may limit antibiotic penetration to the infectious focus. The nonsteroidal anti-inflammatory drug diflunisal was previously identified as an osteoprotective adjunctive therapy for osteomyelitis, based on the ability of this compound to inhibit S. aureus quorum sensing and subsequent quorum-dependent toxin production. When delivered locally during experimental osteomyelitis, diflunisal significantly limits bone destruction without affecting bacterial burdens. However, because diflunisal’s “quorum-quenching” activity could theoretically increase antibiotic recalcitrance, it is critically important to evaluate this adjunctive therapy in the context of standard-of-care antibiotics. The objective of this study is to evaluate the efficacy of vancomycin to treat osteomyelitis during local diflunisal treatment. We first determined that systemic vancomycin effectively reduces bacterial burdens in a murine model of osteomyelitis and identified a dosing regimen that decreases bacterial burdens without eradicating infection. Using this dosing scheme, we found that vancomycin activity is unaffected by the presence of diflunisal in vitro and in vivo. Similarly, locally delivered diflunisal still potently inhibits osteoblast cytotoxicity in vitro and bone destruction in vivo in the presence of subtherapeutic vancomycin. However, we also found that the resorbable polyester urethane (PUR) foams used to deliver diflunisal serve as a nidus for infection. Taken together, these data demonstrate that diflunisal does not significantly impact standard-of-care antibiotic therapy for S. aureus osteomyelitis, but they also highlight potential pitfalls encountered with local drug delivery.

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“…Lysine-based poly(ester urethanes) (PEURs) and poly(thioketal urethanes) (PTKURs) have been previously investigated in bone regeneration applications [ 30 , 31 , 32 , 33 ]. The mechanical properties of these materials can be easily altered, and the addition of ceramic particles, AG, and allograft supports new bone formation at various anatomic sites [ 34 , 35 , 36 , 37 ]. Previous work has demonstrated selective, cell-mediated, first-order degradation of PTKUR in vivo [ 38 ].…”

Section: Introductionmentioning

confidence: 99%

“…Slow degradation is advantageous in applications in which mechanical stability is required; however, in applications utilizing biologics, faster graft resorption is necessary to harness the osteoinductivity. In a previous study, PEUR was used to deliver rhBMP-2 and demonstrated balanced polymer resorption and new bone formation [ 34 , 40 ]. Therefore, we compared PEUR [ 41 , 42 ] with PTKUR [ 38 ] as an AG extender to test the hypothesis that faster degrading PEUR would support increased cellular infiltration and bone formation in a rabbit radius model.…”

Section: Introductionmentioning

confidence: 99%

Settable Polymeric Autograft Extenders in a Rabbit Radius Model of Bone Formation

et al. 2021

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Autograft (AG) is the gold standard for bone grafts, but limited quantities and patient morbidity are associated with its use. AG extenders have been proposed to minimize the volume of AG while maintaining the osteoinductive properties of the implant. In this study, poly(ester urethane) (PEUR) and poly(thioketal urethane) (PTKUR) AG extenders were implanted in a 20-mm rabbit radius defect model to evaluate new bone formation and graft remodeling. Outcomes including µCT and histomorphometry were measured at 12 weeks and compared to an AG (no polymer) control. AG control examples exhibited new bone formation, but inconsistent healing was observed. The implanted AG control was resorbed by 12 weeks, while AG extenders maintained implanted AG throughout the study. Bone growth from the defect interfaces was observed in both AG extenders, but residual polymer inhibited cellular infiltration and subsequent bone formation within the center of the implant. PEUR-AG extenders degraded more rapidly than PTKUR-AG extenders. These observations demonstrated that AG extenders supported new bone formation and that polymer composition did not have an effect on overall bone formation. Furthermore, the results indicated that early cellular infiltration is necessary for harnessing the osteoinductive capabilities of AG.

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Injectable, compression‐resistant polymer/ceramic composite bone grafts promote lateral ridge augmentation without protective mesh in a canine model

Cited by 8 publications

References 41 publications

Synthesis and in vivo evaluation of a scaffold containing wollastonite/β‐TCP for bone repair in a rabbit tibial defect model

Synthesis and in vivo evaluation of a scaffold containing wollastonite/β‐TCP for bone repair in a rabbit tibial defect model

Concurrent Local Delivery of Diflunisal Limits Bone Destruction but Fails To Improve Systemic Vancomycin Efficacy during Staphylococcus aureus Osteomyelitis

Settable Polymeric Autograft Extenders in a Rabbit Radius Model of Bone Formation

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