Injectable enzymatically crosslinked hydrogels based on a poly(l-glutamic acid) graft copolymer

Abstract

Enzyme-mediated injectable hydrogels based on a poly(l-glutamic acid) graft copolymer with tunable physicochemical properties, biodegradability and good biocompatibility were developed.

Multi-responsive hydrogels derived from the self-assembly of tethered allyl-functionalized racemic oligopeptides

“…The generation of peptide-based hydrogels is a topic of intense interest to achieve increased biocompatibility, 18, 19 specific enzymatic response 20, 21 and versatility of supramolecular assembly. 22 The formation of these hydrogel matrices can be attributed, in the majority of cases, to the entanglement of fibrillar structures assembled through noncovalent interactions, such as hydrogen bonding, 23 π - π stacking, 24 electrostatic interactions, 25 and/or hydrophobic interactions.…”

5-Fluorouracil loaded thermosensitive PLGA–PEG–PLGA hydrogels for the prevention of postoperative tendon adhesion

“…The PLGA-PEG-PLGA solutions in PBS (PH 7.4) with different weight concentrations (15,20, and 25 wt%) were prepared at 4 C. The sol-gel phase transitions of the triblock copolymer aqueous solutions were determined by using the vial inverting method as the temperature increased from 10 to 80 C with a temperature interval of 1 C per step. The sol-to-gel transition was recorded in the case of no ow within 30 s aer inverting the vial.…”

“…The rheology experiments of the PLGA-PEG-PLGA triblock polymer solutions in PBS (pH ¼ 7.4) with different concentrations (15,20, and 25 wt%) were investigated using a MCR 302 rheometer (Anton Paar, Austria). The temperature was set to increase from 10 to 70 C at a speed of 0.5 C per minute.…”

“…[12][13][14][15][16] Injectable hydrogels, which may be formed in situ aer injection of the polymeric precursor solutions into the body, have attracted considerable attention for biomedical applications as a result of their unique advantages including a simple and mild gelation process, minimally invasive implantation procedure, good biocompatibility and biodegradability. [12][13][14][15][16] Injectable hydrogels, which may be formed in situ aer injection of the polymeric precursor solutions into the body, have attracted considerable attention for biomedical applications as a result of their unique advantages including a simple and mild gelation process, minimally invasive implantation procedure, good biocompatibility and biodegradability.…”

Self-Healing Hydrogels as Biomedical Scaffolds for Cell, Gene and Drug Delivery

“…Most of the enzymes involved in crosslinking are enzymatic reactions that naturally occur in our bodies with the water environment in neutral pH and at medium temperature. Horse radish peroxidase (HRP) is defined as a class of hemoprotein which can catalyze derivatives of aniline or phenol to form carbon-carbon bond or carbon-nitrogen bond under the condition of the hydrogen peroxide [47] . In addition, the physical and chemical properties of hydrogels, such as gelation rate, mechanical strength and porous structure, can be easily controlled by adjusting the activity of HRP.…”