Injectable fillers: current status, physicochemical properties, function mechanism, and perspectives

Guo, Jingzhong; Fang, Wei; Wang, Feifei

doi:10.1039/d3ra04321e

Cited by 24 publications

(10 citation statements)

References 101 publications

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“…As one of the most commonly used body soft tissue fillers, HA not only plays a filling role but also stimulates the production of skin collagen fibers and various growth factors [18][19][20]. In this study, we demonstrated the efficacy of ultrasound in assessing the filling properties of HA fillers in vivo and found that it could capture uplift data after filling and produce fine-grained data.…”

Section: Discussionmentioning

confidence: 75%

“…Therefore, ultrasound measurement can obtain finer uplift data after filling and can compensate for the shortcomings of the subjective factors in vernier caliper measurement, which leads to large deviations. The source of HA, degree of crosslinking, and differences in the composition of different products affect the duration of the filling effectiveness of the products [19]. Therefore, an ideal animal model and test can provide quantifiable data and indicators for materials research and development.…”

Section: Discussionmentioning

confidence: 99%

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Objective Noninvasive Measurement of the Volumizing Effect of a Dermal Filler: An In Vivo Study

Liu,

Niu,

Shi

et al. 2024

Aesth Plast Surg

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Background Information about the volumizing effects of dermal fillers is critical for physicians’ understanding of product features and prudent decision-making in clinical practice. It is important for material engineers to develop and optimize new dermal fillers, especially when comparing the physiochemical properties of a new product with those of existing fillers that are used worldwide. Objective This study aimed to establish a reliable, noninvasive method for in vivo quantitative evaluation of the filling effect in order to predict possible effectiveness after filler injection and to evaluate the degradation trend over time. Methods A rabbit model of ear injection with dermal fillers was established. Hyaluronic acid (HA) filler was injected into the subcutaneous layer of rabbit ears, resulting in a stable skin bulge. Ultrasonography was used to noninvasively measure the skin bulge for volume calculation; the volume change was analyzed periodically until 38 weeks. Pathological examination, the gold standard, was performed to confirm degradation. Results The immediate volumizing effect of HA filler injection was macroscopically observed as a local skin bulge. Ultrasound was able to precisely detect the shape of the filler and calculate the length, width, and height of the skin bulge at each time point. The degree of uplift and amount of residual samples in the pathological evaluation were consistent with the results of morphological observation using ultrasound. Conclusion Evaluation of the volume impact of dermal filler through the rabbit ear injection model evaluation enables material science evaluation in the early stage of material development, and has certain clinical reference value. Level of Evidence I This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Objective Noninvasive Measurement of the Volumizing Effect of a Dermal Filler: An In Vivo Study

Liu,

Niu,

Shi

et al. 2024

Aesth Plast Surg

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“…Injectable dermal fillers, ranking as the second most common non-invasive aesthetic procedure, are increasingly utilized for soft tissue augmentation and rejuvenation [ 115 ]. These fillers serve to restore volume to skin depressions, thereby contributing to a youthful and rejuvenated appearance [ 116 ].…”

Section: Reviewmentioning

confidence: 99%

“…These fillers serve to restore volume to skin depressions, thereby contributing to a youthful and rejuvenated appearance [ 116 ]. The market currently offers a growing variety of these fillers, with common biodegradable examples including hyaluronic acid, calcium hydroxylapatite, poly-L-lactic acid, and dextran beads in hyaluronic acid [ 115 , 116 ]. While the primary mechanism of action of dermal fillers is to provide sufficient physical volume to compensate for loss, there is also evidence suggesting that these fillers are not inert.…”

Section: Reviewmentioning

confidence: 99%

Clinically Actionable Topical Strategies for Addressing the Hallmarks of Skin Aging: A Primer for Aesthetic Medicine Practitioners

Minoretti,

Emanuele

2024

Cureus

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In this narrative review, we sought to provide a comprehensive overview of the mechanisms underlying cutaneous senescence, framed by the twelve traditional hallmarks of aging. These include genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, impaired macroautophagy, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis. We also examined how topical interventions targeting these hallmarks can be integrated with conventional aesthetic medicine techniques to enhance skin rejuvenation. The potential of combining targeted topical therapies against the aging hallmarks with minimally invasive procedures represents a significant advancement in aesthetic medicine, offering personalized and effective strategies to combat skin aging. The reviewed evidence paves the way for future advancements and underscores the transformative potential of integrating scientifically validated interventions targeted against aging hallmarks into traditional aesthetic practices.

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“…Injectable hydrogels intended for soft-tissue augmentation must exhibit analogous mechanical properties to those of the target tissues and degrade slowly to maintain volume in vivo. Rather than merely occupying space, these hydrogels interact with host cells to perform functions, like promoting subcutaneous cell proliferation, collagen deposition, and tissue regeneration [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Properties of Injectable Hydrogel for Tissue Filling

Xie,

Liu,

Wang

et al. 2024

Pharmaceutics

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Hydrogels with injectability have emerged as the focal point in tissue filling, owing to their unique properties, such as minimal adverse effects, faster recovery, good results, and negligible disruption to daily activities. These hydrogels could attain their injectability through chemical covalent crosslinking, physical crosslinking, or biological crosslinking. These reactions allow for the formation of reversible bonds or delayed gelatinization, ensuring a minimally invasive approach for tissue filling. Injectable hydrogels facilitate tissue augmentation and tissue regeneration by offering slow degradation, mechanical support, and the modulation of biological functions in host cells. This review summarizes the recent advancements in synthetic strategies for injectable hydrogels and introduces their application in tissue filling. Ultimately, we discuss the prospects and prevailing challenges in developing optimal injectable hydrogels for tissue augmentation, aiming to chart a course for future investigations.

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Injectable fillers: current status, physicochemical properties, function mechanism, and perspectives

Abstract: Injectable fillers have great potential in the correction of facial wrinkles and lines. The longevity of injectable fillers varies from 1 month to 5 years based on the physicochemical properties, fabrication strategy, and function mechanism.

Cited by 24 publications

References 101 publications

Objective Noninvasive Measurement of the Volumizing Effect of a Dermal Filler: An In Vivo Study

Objective Noninvasive Measurement of the Volumizing Effect of a Dermal Filler: An In Vivo Study

Clinically Actionable Topical Strategies for Addressing the Hallmarks of Skin Aging: A Primer for Aesthetic Medicine Practitioners

Synthesis and Properties of Injectable Hydrogel for Tissue Filling

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