The popularity of dermal filler injections to treat a range of aesthetic concerns continues to rise worldwide. One area that can be effectively treated using dermal fillers is the cheeks. A lifted, rounded and volumised cheek can help to reflect ambient light to the eyes and restore a youthful look to the face. However, it is important that the rest of the face is considered when planning treatment, as treating one area and neglecting others can lead to an unbalanced look. Furthermore, female and male patients may desire different treatment outcomes, and it is important that this is considered when developing a treatment plan. This article explores the factors that must be considered when volumising the cheeks using dermal fillers. This includes patient assessment, skin quality, predicting outcomes, managing expectations, and product and volume selection. Differences between treating male and female patients are discussed.