2023
DOI: 10.1021/acsami.2c18824
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Injectable, Hierarchically Degraded Bioactive Scaffold for Bone Regeneration

Abstract: Bioactive materials play vital roles in the repair of critical bone defects. However, bone tissue engineering and regenerative medicine are still challenged by the need to repair bone defects evenly and completely. In this study, we functionally simulated the natural creeping substitution process of autologous bone repair by constructing an injectable, hierarchically degradable bioactive scaffold with a composite hydrogel, decalcified bone matrix (DBM) particles, and bone morphogenetic protein 2. This composit… Show more

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Cited by 12 publications
(7 citation statements)
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“…This material showcased active spreading, filling the defect, and offering a robust scaffold for bone regeneration [ 11 ]. Recent advancements have also been seen in other types of injectable materials like ternary calcium-based bone cement, which has been shown to promote bone repair [ 33 ], and hierarchically degradable bioactive scaffolds that mimic the natural bone repair process [ 34 ]. Furthermore, injectable nanocomposite hydrogels, particularly those based on calcium phosphate and alginate, have also shown promise in supporting angiogenic and osteogenic cell functions, which are crucial for bone repair [ 35 ].…”
Section: Main Textmentioning
confidence: 99%
“…This material showcased active spreading, filling the defect, and offering a robust scaffold for bone regeneration [ 11 ]. Recent advancements have also been seen in other types of injectable materials like ternary calcium-based bone cement, which has been shown to promote bone repair [ 33 ], and hierarchically degradable bioactive scaffolds that mimic the natural bone repair process [ 34 ]. Furthermore, injectable nanocomposite hydrogels, particularly those based on calcium phosphate and alginate, have also shown promise in supporting angiogenic and osteogenic cell functions, which are crucial for bone repair [ 35 ].…”
Section: Main Textmentioning
confidence: 99%
“…306 Likewise, an injectable, hierarchically degradable bioactive scaffold with a composite hydrogel, decalcified bone matrix (DBM) particles, and BMP-2 was designed to simulate the natural creeping substitution process of autologous bone repair. 279 The hierarchical degradation rates of the cross-linked hydrogel and DBM particles accelerated tissue ingrowth and bone formation. As reported by Zang et al, an injectable bone morphogenetic protein-7 (BMP-7) and ornidazole (ORN) loaded chitosan/β-glycerophosphate (CS/β-GP) thermosensitive hydrogel was designed and evaluated in class III furcation abnormalities in beagles.…”
Section: Hydrogelmentioning
confidence: 99%
“…In addition to intrinsic osteogenic effects, POSS-gelatin hydrogel also exhibited promising performance as a sustained release system of VEGF and BMP-2, leading to an increase in angiogenesis and osteogenesis . Likewise, an injectable, hierarchically degradable bioactive scaffold with a composite hydrogel, decalcified bone matrix (DBM) particles, and BMP-2 was designed to simulate the natural creeping substitution process of autologous bone repair . The hierarchical degradation rates of the cross-linked hydrogel and DBM particles accelerated tissue ingrowth and bone formation.…”
Section: Polymer Materialsmentioning
confidence: 99%
“…have long been a vital clinical threat to human health. 1,2 Despite their widespread use, autologous and allogeneic bone grafts suffer from drawbacks, such as sacrificial bone donor sites, insufficient supply, and other surgical complications. 3−5 Three-dimensional (3D) printing, also known as additive manufacturing, is an innovative technique for boosting the development of bone tissue engineering, 6−8 because it can meet the clinical needs for personalized design and spatial porous constructs.…”
Section: Introductionmentioning
confidence: 99%
“…Large bone defects resulting from trauma, degenerative diseases, tumors, etc. have long been a vital clinical threat to human health. , Despite their widespread use, autologous and allogeneic bone grafts suffer from drawbacks, such as sacrificial bone donor sites, insufficient supply, and other surgical complications. Three-dimensional (3D) printing, also known as additive manufacturing, is an innovative technique for boosting the development of bone tissue engineering, because it can meet the clinical needs for personalized design and spatial porous constructs. , Among the available material choices, biodegradable polymers are identified as a preferred candidate due to their excellent biocompatibility, suitable mechanical properties, and good processability. , Numerous clinically approved biodegradable polymers, such as polycaprolactone (PCL), poly­(lactic acid) (PLA), and poly­(lactides- co -glycolides) (PLGA), etc., have been employed as the matrices to produce 3D-printed scaffolds. , Unfortunately, the bioinert nature of these biodegradable polymers results in insufficient biofunctions, hindering cellular activities and bone regeneration. , Thus, endowing 3D-printed scaffolds with osteoconductivity and osteogenesis is highly required to ensure their orthopedic applications.…”
Section: Introductionmentioning
confidence: 99%