Injectable hyaluronic acid hydrogels with the capacity for magnetic resonance imaging

Bermejo-Velasco, Daniel; Dou, Weiqiang; Heerschap, Arend; Ossipov, Dmitri; Hilborn, Jöns

doi:10.1016/j.carbpol.2018.06.028

Cited by 32 publications

(16 citation statements)

References 43 publications

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“…Injectable hydrogels based on naturally occurring polymers have gained considerable attention because they are inherently non-inflammatory, biocompatible, non-immunogenic, and biodegradable (Bermejo-Velasco et al., 2018 ). Hyaluronic acid (HA) and its derivatives have been widely used in the clinic and applied to transport and release incorporated proteins and anticancer drugs (Zhang et al., 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Intratumoral injection of anlotinib hydrogel enhances antitumor effects and reduces toxicity in mouse model of lung cancer

et al. 2020

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This study was conducted to determine the antitumor effects and ability of an anlotinib (AL) hydrogel (AL–HA–Tyr) to reduce toxicity in a mouse model of Lewis lung cancer (LLC). We constructed a drug carrier system for AL, verified its effectiveness and systemic safety, and provided a preliminary experimental foundation for clinical carrier transformation. AL–HA–Tyr was prepared by encapsulating AL with hyaluronic acid–tyramine (HA–Tyr) conjugates. Colony and tube formation assays showed that AL–HA–Tyr restrained the proliferation of human umbilical vein endothelial cells (HUVECs) and LLC cells, respectively, in vitro , and that AL exerted significant anti-angiogenesis and anti-tumor effects. The invasion and migration of HUVECs and LLC cells were efficiently suppressed by AL according to transwell assays. HUVEC and LLC cell-cycle and apoptosis analysis clarified the direct anti-tumor effects of AL–HA–Tyr. Mice engrafted with LLC cells in vivo were administered oral saline, oral AL, or an intratumoral injection of HA–Tyr or AL–HA–Tyr. The results showed that AL–HA–Tyr obviously reduced visceral toxicity and decreased Ki67 and VEGF-A expression in tumor cells compared with AL. Furthermore, AL–HA–Tyr significantly prolonged the survival of tumor-bearing mice. Overall, AL–HA–Tyr enhanced antitumor effects and reduced toxicity in the LLC model. It provided a foundation for the clinical transformation of drug carrier systems.

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Section: Introductionmentioning

confidence: 99%

Intratumoral injection of anlotinib hydrogel enhances antitumor effects and reduces toxicity in mouse model of lung cancer

et al. 2020

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“…Consequentially, the shape and global state of the hydrogel can be visualized by a noninvasive MRI, offering a scaffold to monitor long-term reporting of implants. Hydrogels based on enzymatic sensitive carbohydrates were also reported by Hilborn et al 58 They achieved injectable gadolinium-labeled HA, dually functionalized with Gd-DTPA and chemoselective groups. The in situ crosslinking of hyaluronic acid (HA) was based on the hydrazone bond.…”

Section: Hydrogelsmentioning

confidence: 81%

Systematic overview of soft materials as a novel frontier for MRI contrast agents

et al. 2020

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“…While there have been reports of covalent grafting of gadolinium chelates, this has to be done with chemically modified gadolinium chelates. 139 This chemical modification leads to two drawbacks. First, the chelate is no longer an FDA-approved entity, limiting translation.…”

Section: Applications Of Hydrogel Imagingmentioning

confidence: 99%

“…Gadolinium complexes were modified with dithiopyridyl groups and used to label an HA derivative for longitudinal tracking in vivo. 139 In situ forming hydrogels are also of great interest in tissue regeneration as "MRI reporter gels", which serve as smart and responsive polymer implants to deliver drug in vivo and are evaluated by MRI over time. A pH sensitive, injectable, and self-healing chitosan-based hydrogel functionalized with gadolinium chelate was able to self-heal within a pH range based on Schiff-base linkages (Figure 3 A).…”

Section: Applications Of Hydrogel Imagingmentioning

confidence: 99%

Detecting and Monitoring Hydrogels with Medical Imaging

Dong

Bouché

Uman

et al. 2021

ACS Biomater. Sci. Eng.

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Hydrogels, water-swollen polymer networks, are being applied to numerous biomedical applications, such as drug delivery and tissue engineering, due to their potential tunable rheologic properties, injectability into tissues, and encapsulation and release of therapeutics. Despite their promise, it is challenging to assess their properties in vivo and crucial information such as hydrogel retention at the site of administration and in situ degradation kinetics are often lacking. To address this, technologies to evaluate and track hydrogels in vivo with various imaging techniques have been developed in recent years, including hydrogels functionalized with contrast generating material that can be imaged with methods such as X-ray computed tomography (CT), magnetic resonance imaging (MRI), optical imaging, and nuclear imaging systems. In this review, we will discuss emerging approaches to label hydrogels for imaging, review the advantages and limitations of these imaging techniques, and highlight examples where such techniques have been implemented in biomedical applications.

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Injectable hyaluronic acid hydrogels with the capacity for magnetic resonance imaging

Cited by 32 publications

References 43 publications

Intratumoral injection of anlotinib hydrogel enhances antitumor effects and reduces toxicity in mouse model of lung cancer

Intratumoral injection of anlotinib hydrogel enhances antitumor effects and reduces toxicity in mouse model of lung cancer

Systematic overview of soft materials as a novel frontier for MRI contrast agents

Detecting and Monitoring Hydrogels with Medical Imaging

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