Injectable hyaluronic acid/poly(ethylene glycol) hydrogels crosslinked via strain-promoted azide-alkyne cycloaddition click reaction

Fu, Shuangli; Dong, Hui; Deng, Xinyi; Zhuo, Ren‐Xi; Zhong, Zhiyuan

doi:10.1016/j.carbpol.2017.04.028

Cited by 85 publications

(63 citation statements)

References 42 publications

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“…Cells cultured in the hybrid hydrogel exhibit higher viability and proliferation rate than those cultured in pure PAM hydrogel (Han et al, 2017 ). What's more, HA/PEG hybrid hydrogel prepared via the SPAAC crosslinking shows excellent biocompatibility (Fu et al, 2017 ), which may be due to the fact that HA can bond to some receptors on cell membrane to affect both chondrocyte survival pathway and apoptotic pathway (Knudson and Knudson, 2004 ).…”

Section: Control Of Chemical Propertiesmentioning

confidence: 99%

Functional Hydrogels With Tunable Structures and Properties for Tissue Engineering Applications

et al. 2018

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Tissue engineering (TE) has been used as an attractive and efficient process to restore the original tissue structures and functions through the combination of biodegradable scaffolds, seeded cells, and biological factors. As a unique type of scaffolds, hydrogels have been frequently used for TE because of their similar 3D structures to the native extracellular matrix (ECM), as well as their tunable biochemical and biophysical properties to control cell functions such as cell adhesion, migration, proliferation, and differentiation. Various types of hydrogels have been prepared from naturally derived biomaterials, synthetic polymers, or their combination, showing their promise in TE. This review summarizes the very recent progress of hydrogels used for TE applications. The strategies for tuning biophysical and biochemical properties, and structures of hydrogels are first introduced. Their influences on cell functions and promotive effects on tissue regeneration are then highlighted.

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Section: Control Of Chemical Propertiesmentioning

confidence: 99%

Functional Hydrogels With Tunable Structures and Properties for Tissue Engineering Applications

et al. 2018

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“…PEG is biocompatible and biodegradable [134,180]. Modification of crosslinkers used to crosslink acrylate terminated PEG can introduce degradation profiles, for example including 3 wt% of cyclooctyne-hyaluronic acid results in complete degradation in 46 days in pH 9, or 10 days in pH 7.4 with hyaluronidase (HAse) [181]. Concurrently, a study on degradation was reported using rhodamine B mixed with PEGMA as a model drug and its release kinetics shown to be influenced by different device designs, material densities, and porosities [179].…”

Section: Biocompatibility Biodegradability and Bioactivitymentioning

confidence: 99%

Engineered 3D Polymer and Hydrogel Microenvironments for Cell Culture Applications

2019

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The realization of biomimetic microenvironments for cell biology applications such as organ-on-chip, in vitro drug screening, and tissue engineering is one of the most fascinating research areas in the field of bioengineering. The continuous evolution of additive manufacturing techniques provides the tools to engineer these architectures at different scales. Moreover, it is now possible to tailor their biomechanical and topological properties while taking inspiration from the characteristics of the extracellular matrix, the three-dimensional scaffold in which cells proliferate, migrate, and differentiate. In such context, there is therefore a continuous quest for synthetic and nature-derived composite materials that must hold biocompatible, biodegradable, bioactive features and also be compatible with the envisioned fabrication strategy. The structure of the current review is intended to provide to both micro-engineers and cell biologists a comparative overview of the characteristics, advantages, and drawbacks of the major 3D printing techniques, the most promising biomaterials candidates, and the trade-offs that must be considered in order to replicate the properties of natural microenvironments.

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“…[119] One representativer eaction, copperfree azide-alkyne cycloaddition, hasb een employed for encapsulatingc ells using PEG, protein, and hyaluronic acid derivatives ( Figure 3g). [165][166][167][168][169][170][171][172][173][174][175][176] Structurally varied cyclooctyne derivatives that take into account reactionk inetics, hydrophilicity, and synthetic routes have been developed. For example, it has been reported that dibenzylcyclooctynes and bicyclononynes more rapidlyp roduce cross-linked hydrogels than difluorinated cyclooctynes.…”

Section: Ionotropic Encapsulation By Microfluidicdevicementioning

confidence: 99%

Cell‐Surface Engineering for Advanced Cell Therapy

Lee

Choi

et al. 2018

Chemistry A European J

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Stem cells opened great opportunity to overcome diseases that conventional therapy had only limited success. Use of scaffolds made from biomaterials not only helps handling of stem cells for delivery or transplantation but also supports enhanced cell survival. Likewise, cell encapsulation can provide stability for living animal cells even in a state of separateness. Although various chemical reactions were tried to encapsulate stolid microbial cells such as yeasts, a culture environment for the growth of animal cells allows only highly biocompatible reactions. Therefore, the animal cells were mostly encapsulated in hydrogels, which resulted in enhanced cell survival. Interestingly, major findings of chemistry on biological interfaces demonstrate that cell encapsulation in hydrogels have a further a competence for modulating cell characteristics that can go beyond just enhancing the cell survival. In this review, we present a comprehensive overview on the chemical reactions applied to hydrogel-based cell encapsulation and their effects on the characteristics and behavior of living animal cells.

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Injectable hyaluronic acid/poly(ethylene glycol) hydrogels crosslinked via strain-promoted azide-alkyne cycloaddition click reaction

Cited by 85 publications

References 42 publications

Functional Hydrogels With Tunable Structures and Properties for Tissue Engineering Applications

Functional Hydrogels With Tunable Structures and Properties for Tissue Engineering Applications

Engineered 3D Polymer and Hydrogel Microenvironments for Cell Culture Applications

Cell‐Surface Engineering for Advanced Cell Therapy

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