Abstract:In our study, a hybrid alginate hydrogel
cross-linked by calcium gluconate crystals deposited in poly(ε-caprolactone)-b-poly(ethylene glycol)-b-poly(ε-caprolactone)
(PCL-PEG-PCL, abbreviated as PCEC) porous microspheres was developed
for skin engineering. The diameter of microspheres was ∼212
μm, and the pore size was ∼8 μm. The PCEC porous
microspheres supplied different functions in the hydrogel: (1) Calcium
gluconate crystals were loaded in the inner pores of the microspheres,
which can induce alginate h… Show more
“…1,2 Dermal tissue defects following burns, surgical excision, skin trauma and chronic ulcers remain a challenging clinical problem and cause a substantial cost burden on the public. 3,4 The traditional treatments for skin repair include implantation of autologous, allogeneic and exogenous skin gras, which are usually constricted by the lack of donor sources, costly medical expenses and undesirable immunological response. 5,6 Therefore, it is urgently desirable to develop an ideal substitute which is structurally, functionally, and mechanically similar to healthy skin.…”
Cellulose nanocrystal (CNC) is incorporated into Ca2+ cross-linked alginate/gelatin (SA/Ge) scaffold to improve physical, chemical and biological aspects. The SA/Ge/CNC scaffold with enhanced wound healing efficacy is a promising biomaterial for skin defect regeneration.
“…1,2 Dermal tissue defects following burns, surgical excision, skin trauma and chronic ulcers remain a challenging clinical problem and cause a substantial cost burden on the public. 3,4 The traditional treatments for skin repair include implantation of autologous, allogeneic and exogenous skin gras, which are usually constricted by the lack of donor sources, costly medical expenses and undesirable immunological response. 5,6 Therefore, it is urgently desirable to develop an ideal substitute which is structurally, functionally, and mechanically similar to healthy skin.…”
Cellulose nanocrystal (CNC) is incorporated into Ca2+ cross-linked alginate/gelatin (SA/Ge) scaffold to improve physical, chemical and biological aspects. The SA/Ge/CNC scaffold with enhanced wound healing efficacy is a promising biomaterial for skin defect regeneration.
“…Despite that the injectable hydrogels have 3D structure with massive pores, it is difficult for cells to attach themselves on these pores. Qian and coworkers fabricated a porous microsphere injectable hydrogel consisted of poly(ε‐caprolactone)‐ b ‐poly(ethylene glycol)‐ b ‐poly(ε‐caprolactone) (PCL–PEG–PCL, abbreviate as PCEC) polymer with a rough surface . The porous microspheres hold calcium gluconate crystals in their insider pores, forming injectable crosslinked alginate hydrogel.…”
Section: Biomedical Applications Of Polysaccharides and Polysaccharidmentioning
Polysaccharide is an abundant and reproducible natural material that is biocompatible and biodegradable. Polysaccharide and its derivatives also possess distinctive properties such as hydrophilicity, mechanical stability, as well as tunable functionality. Polysaccharide‐based hydrogels can be constructed via the physical and/or chemical crosslinking of polysaccharide derivatives with different functional molecules, as porous network structures or nanofibrillar structures. This review discusses the biomedical applications of polysaccharide‐based hydrogels containing native polysaccharides, polysaccharide derivatives, and polysaccharide‐composite hydrogels. Recent works on the fabrication, physical properties, advanced engineering, biomedical applications of cellulose‐, chitosan‐, alginate‐, and starch‐based hydrogels are also elaborated. Such porous swelling scaffolds exhibit great advantages at the interface of a negative pressure system such as wound dressing. In addition, the authors also discuss and summarize the exemplary research works of these hydrogels in the applications of drug release, wound dressing, and tissue engineering. Finally, challenges and future perspectives about the development of polysaccharide‐based hydrogels are discussed.
“…PVA hydrogels for wound healing often include other materials to stimulate the wound healing response such as curcumin [16] or zinc oxide nanoparticles [17] for antibacterial properties, and phlorotannins, derived from brown algae, which have been shown to promote fibroblast migration [18]. A polymer similar to PVA, poly(ethylene glycol) (PEG), is also commonly used for the fabrication of hydrogels, where Polymyxin B conjugated to PEG [19] has been shown to be antibacterial, and when combined as a hybrid with alginate can promote wound regeneration [20]. Advances in hydrogel polymerization methods also enable the use of injectable hydrogels (Fig.…”
Section: Reviewmentioning
confidence: 99%
“…Advances in hydrogel polymerization methods also enable the use of injectable hydrogels (Fig. 4b) [20], which can be directly delivered onto a patients wound enabling complete and customized coverage.Fig. 4Various types of hydrogels have been, and are continuing to be used as wound healing therapeutics including hydrogels formed from the biopolymer a Hyaluronan hydrogel.…”
There is a vast number of treatments on the market for the management of wounds and burns, representing a multi-billion dollar industry worldwide. These include conventional wound dressings, dressings that incorporate growth factors to stimulate and facilitate the wound healing process, and skin substitutes that incorporate patient-derived cells. This article will review the more established, and the recent advances in the use of biomaterials for wound healing therapies, and their future direction.
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