Injectable hydrogel-incorporated cancer cell-specific cisplatin releasing nanogels for targeted drug delivery

Gil, Moon Soo; Thambi, Thavasyappan; Phan, Vu To-Anh; Kim, Seong Han; Lee, Sang Soo

doi:10.1039/c7tb00873b

Cited by 65 publications

(39 citation statements)

References 46 publications

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“…152 In the same way, cisplatin-bearing chondroitin sulfate-nanogels were obtained, which were then incorporated into pH-and temperature-responsive bioresorbable PEG-poly(b-aminoester urethane) hydrogels for the cancer cell-specic delivery of cisplatin. 153 DDSs based on metal complexes with natural polymers have several advantages that allow you to control the release of drugs, avoid the use of hazardous organic solvents in the manufacture of samples, improve the pharmacokinetics and increase the biodistribution of therapeutic agents in target organs, which leads to increased efficiency, including a non-invasive drug delivery method. In addition, they have a wide molecular weight distribution, a variety of viscoelastic properties, biocompatibility, phase transition characteristics and an acceptable taste.…”

Section: Metal-containing Natural Polymersmentioning

confidence: 99%

Recent advances in metallopolymer-based drug delivery systems

et al. 2019

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Section: Metal-containing Natural Polymersmentioning

confidence: 99%

Recent advances in metallopolymer-based drug delivery systems

et al. 2019

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“…It is known that poly(ꞵ-aminoester) [ 48 ] and PEI [ 49 ] polymers alone or combined in the copolymers can contribute to the pH-buffering capacity in the physiological condition. The pH-buffering capacity of different PPA copolymers was investigated by preparing the conjugate solution in pH 3.0 and assessing the pH-buffering capacity in response to the change in pH of the copolymer solution titrated against 0.1N NaOH.…”

Section: Resultsmentioning

confidence: 99%

A pH- and Bioreducible Cationic Copolymer with Amino Acids and Piperazines for Adenovirus Delivery

et al. 2022

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Adenoviruses (Ads) are attractive nonviral vectors and show great potential in cancer gene therapy. However, inherent properties of Ads, including immunogenicity, nonspecific toxicity, and coxsackie and adenovirus receptor (CAR)-dependent cell uptake, limit their clinical use. To surmount these issues, we developed a pH- and glutathione-responsive poly(ethylene glycol)-poly(ꞵ-aminoester)-polyethyleneimine (PPA) for conjugation with Ad. The pH sensitivity of the PPA copolymer was elegantly tuned by substitution with different amino acids (arginine, histidine, and tryptophan), piperazines (Pip1, Pip2, and Pip3), and guanidine residues in the backbone of the PPA conjugate. PPA copolymer was further functionalized with short-chain cross-linker succinimidyl 3-(2-pyridyldithio)propionate) (SPDP) to obtain PPA-SPDP for facile conjugation with Ad. The PPA-conjugated Ad (PPA-Ad) conjugate was obtained by reacting PPA-SPDP conjugate with thiolated Ad (Ad-SH). Ad-SH was prepared by reacting Ad with 2-iminothiolane. The size distribution and zeta potential results of PPA-Ad conjugate showed an increasing trend with an increase in copolymer dose. From in vitro test, it was found that the transduction efficiency of PPA-Ad conjugate in CAR-positive cells (A549 and H460 cells) was remarkably increased at the acidic pH condition (pH 6.2) when compared with PPA-Ad conjugate incubated under the physiological condition (pH 7.4). Interestingly, the increase in transduction efficiency was evidenced in CAR-negative cells (MDA-MB-231 and T24 cells). These results demonstrated that biocompatible and biodegradable PPA copolymers can efficiently cover the surface of Ad and can increase the transduction efficiency, and hence PPA copolymers can be a useful nanomaterial for viral vector delivery in cancer therapy.

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“…In particular, exploiting the influence of pH and temperature on the self-assembly capacity of this polymeric material, a dual drug delivery system was proposed as a carrier for the regional release of DOX in the liver compartment. Additionally, target-specific release of CisPt was proposed by incorporation of CisPt chondroitin sulfate-based nanogels into pH- and temperature-responsive PEG–PAEU hydrogels [119]. In this case, ionic interactions, under physiological conditions, between the tertiary amine and sulfate groups allowed to form hydrogel networks able to selectively bind a receptor specifically expressed on cancer cells [120].…”

Section: Synthetic Injectable Hydrogelsmentioning

confidence: 99%

Injectable Hydrogels for Cancer Therapy over the Last Decade

et al. 2019

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The interest in injectable hydrogels for cancer treatment has been significantly growing over the last decade, due to the availability of a wide range of starting polymer structures with tailored features and high chemical versatility. Many research groups are working on the development of highly engineered injectable delivery vehicle systems suitable for combined chemo-and radio-therapy, as well as thermal and photo-thermal ablation, with the aim of finding out effective solutions to overcome the current obstacles of conventional therapeutic protocols. Within this work, we have reviewed and discussed the most recent injectable hydrogel systems, focusing on the structure and properties of the starting polymers, which are mainly classified into natural or synthetic sources. Moreover, mapping the research landscape of the fabrication strategies, the main outcome of each system is discussed in light of possible clinical applications.

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Injectable hydrogel-incorporated cancer cell-specific cisplatin releasing nanogels for targeted drug delivery

Abstract: pH- and temperature-responsive bioresorbable poly(ethylene glycol)–poly(aminoester urethane) copolymer incorporated cisplatin-bearing chondroitin sulfate nanogels have been developed for cancer cell-specific delivery of cisplatin.

Cited by 65 publications

References 46 publications

Recent advances in metallopolymer-based drug delivery systems

Recent advances in metallopolymer-based drug delivery systems

A pH- and Bioreducible Cationic Copolymer with Amino Acids and Piperazines for Adenovirus Delivery

Injectable Hydrogels for Cancer Therapy over the Last Decade

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