Injectable hydrogels as drug delivery platform for in-situ treatment of malignant tumor

Ma, Qiang; Li, Qiang; X, Cai; Zhou, Ping; Wu, Zhi‐Ying; Wang, Biqiong; Ma, Wenqiong; Shao, Fu

doi:10.1016/j.jddst.2022.103817

Cited by 9 publications

(4 citation statements)

References 100 publications

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“…Another highly investigated and widely reviewed type of nanomedicine is polymeric systems combined with biomaterials for pH-responsive TME targeting. These include hydrogels [ 239 ], polymer nanoparticles [ 240 , 241 ], and micelles [ 242 ]. Despite the effort, the complex biological characteristics and aggressiveness of the acidic microenvironment of solid tumors remains a challenge for effective delivery.…”

Section: Nanomedicines For Targeting Tme: Application Of Natural and ...mentioning

confidence: 99%

Biomaterial-Based Responsive Nanomedicines for Targeting Solid Tumor Microenvironments

Avgoustakis,

Angelopoulou

2024

Pharmaceutics

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Solid tumors are composed of a highly complex and heterogenic microenvironment, with increasing metabolic status. This environment plays a crucial role in the clinical therapeutic outcome of conventional treatments and innovative antitumor nanomedicines. Scientists have devoted great efforts to conquering the challenges of the tumor microenvironment (TME), in respect of effective drug accumulation and activity at the tumor site. The main focus is to overcome the obstacles of abnormal vasculature, dense stroma, extracellular matrix, hypoxia, and pH gradient acidosis. In this endeavor, nanomedicines that are targeting distinct features of TME have flourished; these aim to increase site specificity and achieve deep tumor penetration. Recently, research efforts have focused on the immune reprograming of TME in order to promote suppression of cancer stem cells and prevention of metastasis. Thereby, several nanomedicine therapeutics which have shown promise in preclinical studies have entered clinical trials or are already in clinical practice. Various novel strategies were employed in preclinical studies and clinical trials. Among them, nanomedicines based on biomaterials show great promise in improving the therapeutic efficacy, reducing side effects, and promoting synergistic activity for TME responsive targeting. In this review, we focused on the targeting mechanisms of nanomedicines in response to the microenvironment of solid tumors. We describe responsive nanomedicines which take advantage of biomaterials’ properties to exploit the features of TME or overcome the obstacles posed by TME. The development of such systems has significantly advanced the application of biomaterials in combinational therapies and in immunotherapies for improved anticancer effectiveness.

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Section: Nanomedicines For Targeting Tme: Application Of Natural and ...mentioning

confidence: 99%

Biomaterial-Based Responsive Nanomedicines for Targeting Solid Tumor Microenvironments

Avgoustakis,

Angelopoulou

2024

Pharmaceutics

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“…(iv) Controlled release. Injectable hydrogels are ideal drug delivery systems with the potential for non-invasive drug delivery, 16,[22][23][24][25] and in vivo gel-sol transition enables localized drug delivery avoiding the problems of systemic drug delivery and increasing the local drug concentration. 25,26 It can spatially and temporally control the release of loaded thera- peutic agents and prolong their action by modulating physical or chemical properties.…”

Section: Brief Introduction To Hydrogelsmentioning

confidence: 99%

Injectable hydrogels as emerging drug-delivery platforms for tumor therapy

Cheng,

Zhang,

Wei

et al. 2024

Biomater. Sci.

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“…Hydrogel-based flexible conductive materials exhibit mechanical properties similar to those of the skin, displaying good biocompatibility and stable and sensitive responses to external stimulus signals [14,15]. These qualities have greatly increased their application potential in the realm of sensing [16][17][18], including the monitoring of electrocardiogram and electroencephalogram signals [19], soft robotics [20], human motion monitoring [21], controlled drug release [22], photothermal therapy [23], and smart wound dressing [24,25].…”

Section: Introductionmentioning

confidence: 99%

Recent Progress of Anti-Freezing, Anti-Drying, and Anti-Swelling Conductive Hydrogels and Their Applications

Li,

Cheng,

Deng

et al. 2024

Polymers

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Hydrogels are soft–wet materials with a hydrophilic three-dimensional network structure offering controllable stretchability, conductivity, and biocompatibility. However, traditional conductive hydrogels only operate in mild environments and exhibit poor environmental tolerance due to their high water content and hydrophilic network, which result in undesirable swelling, susceptibility to freezing at sub-zero temperatures, and structural dehydration through evaporation. The application range of conductive hydrogels is significantly restricted by these limitations. Therefore, developing environmentally tolerant conductive hydrogels (ETCHs) is crucial to increasing the application scope of these materials. In this review, we summarize recent strategies for designing multifunctional conductive hydrogels that possess anti-freezing, anti-drying, and anti-swelling properties. Furthermore, we briefly introduce some of the applications of ETCHs, including wearable sensors, bioelectrodes, soft robots, and wound dressings. The current development status of different types of ETCHs and their limitations are analyzed to further discuss future research directions and development prospects.

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Injectable hydrogels as drug delivery platform for in-situ treatment of malignant tumor

Cited by 9 publications

References 100 publications

Biomaterial-Based Responsive Nanomedicines for Targeting Solid Tumor Microenvironments

Biomaterial-Based Responsive Nanomedicines for Targeting Solid Tumor Microenvironments

Injectable hydrogels as emerging drug-delivery platforms for tumor therapy

Recent Progress of Anti-Freezing, Anti-Drying, and Anti-Swelling Conductive Hydrogels and Their Applications

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