Injectable hydrogels for anti‐tumour treatment: a review

He, Huan; Xie, Chaoming; Li, Xiong

doi:10.1049/bsbt.2020.0020

Cited by 5 publications

(6 citation statements)

References 134 publications

(148 reference statements)

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“…In contrast to chemical crosslinking, physical gelation is induced by minor changes in pH, temperature, and ionic concentration or strength, which can be an essential factor for the success of gelation. [25,59,60] Compared to physical crosslinking, chemical crosslinking usually generates more stable hydrogels with better mechanical properties (strength and stability). The primary shortcoming of chemical crosslinking is the toxicity due to the reactive components and/or reaction intermediates of photoirradiation.…”

Section: Development Of Injectable Hydrogel: Crosslinking Chemistrymentioning

confidence: 99%

Injectable Adhesive Hydrogels for Soft tissue Reconstruction: A Materials Chemistry Perspective

Mondal

Chakraborty

Chatterjee

2022

The Chemical Record

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Injectable bioadhesives offer several advantages over conventional staples and sutures in surgery to seal and close incisions or wounds. Despite the growing research in recent years few injectable bioadhesives are available for clinical use. This review summarizes the key chemical features that enable the development and improvements in the use of polymeric injectable hydrogels as bioadhesives or sealants, their design requirements, the gelation mechanism, synthesis routes, and the role of adhesion mechanisms and strategies in different biomedical applications. It is envisaged that developing a deep understanding of the underlying materials chemistry principles will enable researchers to effectively translate bioadhesive technologies into clinically‐relevant products.

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Section: Development Of Injectable Hydrogel: Crosslinking Chemistrymentioning

confidence: 99%

Injectable Adhesive Hydrogels for Soft tissue Reconstruction: A Materials Chemistry Perspective

Mondal

Chakraborty

Chatterjee

2022

The Chemical Record

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“…Injectable hydrogels are an ideal strategy for managing the irregular structures [204] adapted to local bone defects [205,206]. Mu et al [172] developed an injectable autologous platelet-rich fibrin hydrogel based on modifications to gelatin nanoparticles (Figure 8a); the hydrogel mimicked the ECM and could withstand the pressure of maxillary sinus formation during animal breathing.…”

Section: Bone Tissue Repairmentioning

confidence: 99%

“…Injectable hydrogels are an ideal strategy for managing the irregular structures [204] adapted to local bone defects [205, 206]. Mu et al.…”

Section: Advanced Applications Of Adhesive Hydrogelsmentioning

confidence: 99%

Natural polymer‐based adhesive hydrogel for biomedical applications

Long

Xie

2022

Biosurface and Biotribology

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Hydrogel is a polymer network system that can form a hydrophilic three‐dimensional network structure through different cross‐linking methods. In recent years, hydrogels have received considerable attention due to their good biocompatibility and biodegradability by introducing different cross‐linking mechanisms and functional components. Compared with synthetic hydrogels, natural polymer‐based hydrogels have low biotoxicity, high cell affinity, and great potential for biomedical fields; however, their mechanical properties and tissue adhesion capabilities have been unable to meet clinical requirements. In recent years, many efforts have been made to solve these issues. In this review, the recent progress in the field of natural polymer‐based adhesive hydrogels is highlighted. The authors first introduce the general design principles for the natural polymer‐based adhesive hydrogels being used as excellent tissue adhesives and the challenges associated with their design. Next, their usages in biomedical applications are summarised, such as wound healing, haemostasis, nerve repair, bone tissue repair, cartilage tissue repair, electronic devices, and other tissue repairs. Finally, the potential challenges of natural polymer‐based adhesive hydrogels are presented.

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“…ROS and downstream signalling pathway inhibitors, such as the PPARγ coactivator 1α (PGC-1 α) transcriptional coactivators 61 and ferritin heavy chain (FHC) 62 , have been demonstrated to reduce ROS levels and protect neurons from apoptosis. However, it should also be noted that the presence of ROS in neurons is vital for their development, and is essential for synaptic plasticity and memory formation, and they play a fundamental role in metabolism and energy perfusion 16 .…”

Section: Ros Generation In Neurodegeneration and Other Diseasesmentioning

confidence: 99%

“…As one of the major goals of hydrogel-based technology, injectable hydrogel, polymeric gel precursors that can be injected and in situ crosslinked to form hydrogels in vivo, have attracted increasing attention and developed many drug delivery and tissue engineering applications [14][15][16][17][18][19][20] . Relying on the diversification of in situ formation mechanisms, vast combinations of functional polymers and minimally invasive implantation, injectable hydrogels are capable of meeting specific requirements for various pathological conditions.…”

Section: Introductionmentioning

confidence: 99%