Injectable hydrogels for personalized cancer immunotherapies

Mohaghegh, Neda; Ahari, Amir; Zehtabi, Fatemeh; Buttles, Claire; Davani, Saya; Hoang, Hanna; Tseng, Kaylee; Zamanian, Benjamin; Khosravi, Safoora; Daniali, Ariella; Kouchehbaghi, Negar Hosseinzadeh; Thomas, Isabel; Serati Nouri, Hamed; Khorsandi, Danial; Abbasgholizadeh, Reza; Akbari, Mohsen; Patil, Rameshwar; Kang, Heemin; Jucaud, Vadim; Khademhosseini, Ali; Hassani Najafabadi, Alireza

doi:10.1016/j.actbio.2023.10.002

Cited by 23 publications

(5 citation statements)

References 185 publications

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“…These cells are then integrated into a suitable biomaterial, chosen based on the specific bioprinting method employed. 115–117 This development of in vitro cancer models capable of emulating drug responses unique to each patient is a major focus in personalized medicine. 118 Despite this, the current technologies used in crafting such models primarily reproduce only the morphological diversity found in human cancer tissues.…”

Section: Application Of Printable Biomaterials For Cancer Therapymentioning

confidence: 99%

Application of 3D, 4D, 5D, and 6D bioprinting in cancer research: what does the future look like?

Khorsandi,

Rezayat,

Sezen

et al. 2024

J. Mater. Chem. B

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Section: Application Of Printable Biomaterials For Cancer Therapymentioning

confidence: 99%

Application of 3D, 4D, 5D, and 6D bioprinting in cancer research: what does the future look like?

Khorsandi,

Rezayat,

Sezen

et al. 2024

J. Mater. Chem. B

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“… 655 The use of hydrogel systems in this context not only facilitates the co-delivery of multiple therapeutic agents but also provides varied drug-binding sites, enabling a more controlled and sustained release of drugs, thereby addressing the challenges posed by the complexity of TMEs. 656 For instance, Mirrahimi et al developed a thermosensitive alginate hydrogel loaded with cisplatin and AuNPs for achieving a tripartite combination of thermo-chemo-radio modality. 657 The incorporated AuNPs acted as a potent radiosensitizer, leveraging their substantial X-ray absorption capabilities, while also functioning as a thermal source upon exposure to 532 nm laser irradiation, thereby enabling photothermal destruction of tumor cells.…”

Section: Hydrogels For Non-cell Therapymentioning

confidence: 99%

Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions

Lu,

Ruan,

Huang

et al. 2024

Sig Transduct Target Ther

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The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial technologies. In this review, we cover the major achievements and the potential of hydrogels in therapeutic applications, focusing primarily on two areas: emerging cell-based therapies and promising non-cell therapeutic modalities. Within the context of cell therapy, we discuss the capacity of hydrogels to overcome the existing translational challenges faced by mainstream cell therapy paradigms, provide a detailed discussion on the advantages and principal design considerations of hydrogels for boosting the efficacy of cell therapy, as well as list specific examples of their applications in different disease scenarios. We then explore the potential of hydrogels in drug delivery, physical intervention therapies, and other non-cell therapeutic areas (e.g., bioadhesives, artificial tissues, and biosensors), emphasizing their utility beyond mere delivery vehicles. Additionally, we complement our discussion on the latest progress and challenges in the clinical application of hydrogels and outline future research directions, particularly in terms of integration with advanced biomanufacturing technologies. This review aims to present a comprehensive view and critical insights into the design and selection of hydrogels for both cell therapy and non-cell therapies, tailored to meet the therapeutic requirements of diverse diseases and situations.

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“…Cancer has long been one of the deadliest diseases threatening human life. − Due to the complexity, diversity, and heterogeneity of tumors, traditional treatment methods have limited treatment efficiency and cannot completely cure cancer in most cases . In recent years, the progress of cancer treatment has gradually shifted from monotherapy to the combination of multiple treatment methods. , This multimodal therapy refers to the combination of two or more medical approaches such as surgery, chemotherapy (CT), , radiotherapy (RT), , high-intensity focused ultrasound (HIFU), gene therapy, , photodynamic therapy (PDT), , photothermal therapy (PTT), , and immunotherapy. , Different from monotherapy, multimodal treatments have the characteristics of reducing drug dose, enhancing efficacy, and fewer side effects, showing much higher promise for the antitumor therapy. , …”

Section: Introductionmentioning

confidence: 99%

“…5,6 This multimodal therapy refers to the combination of two or more medical approaches such as surgery, 7 chemotherapy (CT), 8,9 radiotherapy (RT), 10,11 high-intensity focused ultrasound (HIFU), 12 gene therapy, 13,14 photodynamic therapy (PDT), 15,16 photothermal therapy (PTT), 17,18 and immunotherapy. 19,20 Different from monotherapy, multimodal treatments have the characteristics of reducing drug dose, enhancing efficacy, and fewer side effects, showing much higher promise for the antitumor therapy. 6,21 Several studies have shown that combining PDT with gene therapy can synergistically improve the killing efficiency of tumor cells.…”

Section: Introductionmentioning

confidence: 99%

ROS-Responsive Bola-Lipid Nanoparticles as a Codelivery System for Gene/Photodynamic Combination Therapy

Zhao,

Zhang,

Tian

et al. 2024

Mol. Pharmaceutics

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The nonviral delivery systems that combine genes with photosensitizers for multimodal tumor gene/photodynamic therapy (PDT) have attracted much attention. In this study, a series of ROS-sensitive cationic bola-lipids were applied for the gene/ photosensitizer codelivery. Zn-DPA was introduced as a cationic headgroup to enhance DNA binding, while the hydrophobic linking chains may facilitate the formation of lipid nanoparticles (LNP) and the encapsulation of photosensitizer Ce6. The length of the hydrophobic chain played an important role in the gene transfection process, and 14-TDZn containing the longest chains showed better DNA condensation, gene transfection, and cellular uptake. 14-TDZn LNPs could well load photosensitizer Ce6 to form 14-TDC without a loss of gene delivery efficiency. 14-TDC was used for codelivery of p53 and Ce6 to achieve enhanced therapeutic effects on the tumor cell proliferation inhibition and apoptosis. Results showed that the codelivery system was more effective in the inhibition of tumor cell proliferation than individual p53 or Ce6 monotherapy. Mechanism studies showed that the production of ROS after Ce6 irradiation could increase the accumulation of p53 protein in tumor cells, thereby promoting caspase-3 activation and inducing apoptosis, indicating some synergistic effect. These results demonstrated that 14-TDC may serve as a promising nanocarrier for gene/PDT combination therapy.

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Injectable hydrogels for personalized cancer immunotherapies

Cited by 23 publications

References 185 publications

Application of 3D, 4D, 5D, and 6D bioprinting in cancer research: what does the future look like?

Application of 3D, 4D, 5D, and 6D bioprinting in cancer research: what does the future look like?

Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions

ROS-Responsive Bola-Lipid Nanoparticles as a Codelivery System for Gene/Photodynamic Combination Therapy

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