Injectable hydrogels for treatment of osteoarthritis – A rheological study

Lospichl, Benjamin von; Hemmati‐Sadeghi, Shabnam; Dey, Pradip; Dehne, Tilo; Haag, Rainer; Sittinger, Michael; Ringe, Jochen; Gradzielski, Michael

doi:10.1016/j.colsurfb.2017.07.073

Cited by 37 publications

(33 citation statements)

References 23 publications

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“…[332] Such approaches can also be utilized to target cells other than tumor cells, a thermo-responsive HA nanogel drug delivery system which targets macrophages has been developed. [246,334] The examples outlined in Tables 7 and 8 clearly demonstrate the versatility of HA as a delivery vehicle.…”

Section: Versatility Of Conjugated Ha As a Delivery Vehicle For Theramentioning

confidence: 95%

“…[241] The elasticity of HA increases with increasing molecular weight and concentration of the HA molecular network. [242][243][244][245][246] Synovial fluid HA in normal healthy knees has a molecular weight of 7 × 10 6 Da whereas HA in the OA or RA knee HA has a molecular weight of 4.8-5.0 × 10 6 Da. [240] Commercial preparations of HA of variable sizes are available ( Table 5).…”

Section: Synovial Fluid Hamentioning

confidence: 99%

“…[239] Native synovial HA is a thixotropic non-Newtonian viscoelastic solution whose viscosity is shear dependent. [240][241][242][243][244][245][246] At high shear the viscosity of HA gels may drop by as much as 10 3 times and it then obeys as a Newtonian fluid. [241] The elasticity of HA increases with increasing molecular weight and concentration of the HA molecular network.…”

Section: Synovial Fluid Hamentioning

confidence: 99%

“…These differ in their rheological characteristics in vitro and the properties they convey to synovial fluid and joint-lubrication in vivo. [242][243][244][245][246] Synovial fluid HA in normal healthy knees has a molecular weight of 7 × 10 6 Da whereas HA in the OA or RA knee HA has a molecular weight of 4.8-5.0 × 10 6 Da. [247] HA in the OA knee has a broad polydisperse size distribution with a weight average molecular weight of 1.2-4.5 × 10 6 Da, whereas the HA from a normal joint has a weight average molecular weight of 1.6-10.9 × 10 6 Da.…”

Section: Synovial Fluid Hamentioning

confidence: 99%

“…A number of glycopolymers with appropriate rheological properties and low cytotoxity have also been evaluated with a view to application in viscosupplementation procedures. [246,334]…”

Section: Versatility Of Conjugated Ha As a Delivery Vehicle For Theramentioning

confidence: 99%

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Glycosaminoglycan and Proteoglycan Biotherapeutics in Articular Cartilage Protection and Repair Strategies: Novel Approaches to Visco‐supplementation in Orthobiologics

Hayes

Melrose

2019

Advanced Therapeutics

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The aim of this study is to review developments in glycosaminoglycan and proteoglycan research relevant to cartilage repair biology and in particular the treatment of osteoarthritis (OA). Glycosaminoglycans decorate a diverse range of extracellular matrix and cell associated proteoglycans conveying structural organization and physico-chemical properties to tissues. They play key roles mediating cellular interactions with bioactive growth factors, cytokines, and morphogenetic proteins, and structural fibrillar collagens, cell interactive and extracellular matrix proteoglycans, and glycoproteins which define tissue function. Proteoglycan degradation detrimentally affects tissue functional properties. Therapeutic strategies have been developed to counter these degenerative changes. Neo-proteoglycans prepared from chondroitin sulfate or hyaluronan and hyaluronan or collagen-binding peptides emulate the interactive, water imbibing, weight bearing, and surface lubricative properties of native proteoglycans. Many neo-proteoglycans outperform native proteoglycans in terms of water imbibition, matrix stabilization, and resistance to proteolytic degradation. The biospecificity of recombinant proteoglycans however, provides precise attachment to native target molecules. Visco-supplements augmented with growth factors/therapeutic cells, hyaluronan, and lubricin (orthobiologicals) have the capacity to lubricate and protect cartilage, control inflammation, and promote cartilage repair and regeneration of early cartilage lesions and may represent a more effective therapeutic approach to the treatment of mild to moderate OA and deserve further study.Similar protective perineural net structures assembled from the lectican proteoglycan family and HA also occur in the CNS/PNS. These so called perineuronal nets are visualized by immunolocalization of MAb 1B5 (+) epitope in rat brain (e) and pericellular 1B5(+) epitope expression by isolated neurons (f). Scale bars 100 µm.

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Section: Versatility Of Conjugated Ha As a Delivery Vehicle For Theramentioning

confidence: 95%

Section: Synovial Fluid Hamentioning

confidence: 99%

Section: Synovial Fluid Hamentioning

confidence: 99%

Section: Synovial Fluid Hamentioning

confidence: 99%

“…A number of glycopolymers with appropriate rheological properties and low cytotoxity have also been evaluated with a view to application in viscosupplementation procedures. [246,334]…”

Section: Versatility Of Conjugated Ha As a Delivery Vehicle For Theramentioning

confidence: 99%

See 3 more Smart Citations

Glycosaminoglycan and Proteoglycan Biotherapeutics in Articular Cartilage Protection and Repair Strategies: Novel Approaches to Visco‐supplementation in Orthobiologics

Hayes

Melrose

2019

Advanced Therapeutics

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Engineering of Viscosupplement Biomaterials for Treatment of Osteoarthritis: A Comprehensive Review

et al. 2022

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Osteoarthritis (OA) is a progressive degenerative disease that causes severe pain and functional limitation, especially during locomotion. It is the most common arthritis type that damages the surface of articular cartilage until the underlying bone. In the past decade, the scientific community has made a considerable effort to improve or discover therapeutical products used as a form of conservative treatment capable of restoring the damaged articular tissue, avoiding, as far as possible, the use of surgical practices. The most common and direct nonoperative application available for OA treatment is the viscosupplementation (VS) procedure that demonstrates a safe, effective method and is less painful for the patients. The most recent works dealing with the design, development, and validation of viscosupplement products in preclinical and clinical trials for OA treatment are overviewed herein. In general, despite the development of new products, hyaluronic acid continues to be among the most reported intra‐articular viscosupplement products used in clinical trials, typically used as an isolated product or conjugated with other biologicals or drugs, such as platelet‐rich plasma and corticosteroids (CS). However, this issue is still demanding innovation. Approaches comprising new biomaterials as VS products, with intrinsic bioactivity, economical, and environmental friendliness, are required.

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Locally Injectable, ROS‐Scavenging, and ROS‐/pH‐Responsive Polymeric‐Micelles‐Embedded Hydrogels for Precise Minimally Invasive and Long‐Lasting Rheumatoid Therapy

Liu,

Chen,

Fei

et al. 2024

Adv Healthcare Materials

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Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovitis, bone‐erosion, and joint‐destruction. Here, we developed a locally injectable, ROS‐scavenging, and ROS‐/pH‐responsive drug‐delivery platform (HC@PTM) by bio‐compositing of aldolizing hyaluronic acid (HA) crosslinked with chitosan (CS), and ROS‐triggered/eliminated micelles (PTM) coupled with the drug methotrexate(MTX). The PTM efficiently eradicate excessive ROS in RA‐joints, precisely triggering drug‐release within inflamed arthritic‐sites and further confer exceptional antioxidant origins to HC@PTM. HC@PTM with outstanding shape‐adaptability and self‐repairing properties effectively conformed to irregular articular cartilage while resisting joint‐induced deformations. Further, the platform's pH‐responsive nature enables on‐demand drug‐release within acidic inflamed synovium, serving as a drug‐reservoir for precise and sustained therapeutic effects. Extensive in vitro and in vivo investigations confirm HC@PTM's ability to induce M2 macrophage polarization, downregulate inflammatory factor expression, and ameliorate the RA‐microenvironment, ultimately achieving synergistic therapeutic outcomes. This study represents significant advancements in precise and long‐term RA‐treatment through a minimally invasive approach, offering potential strategies for novel precision medicine.

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Injectable hydrogels for treatment of osteoarthritis – A rheological study

Cited by 37 publications

References 23 publications

Glycosaminoglycan and Proteoglycan Biotherapeutics in Articular Cartilage Protection and Repair Strategies: Novel Approaches to Visco‐supplementation in Orthobiologics

Glycosaminoglycan and Proteoglycan Biotherapeutics in Articular Cartilage Protection and Repair Strategies: Novel Approaches to Visco‐supplementation in Orthobiologics

Engineering of Viscosupplement Biomaterials for Treatment of Osteoarthritis: A Comprehensive Review

Locally Injectable, ROS‐Scavenging, and ROS‐/pH‐Responsive Polymeric‐Micelles‐Embedded Hydrogels for Precise Minimally Invasive and Long‐Lasting Rheumatoid Therapy

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