Injectable In Situ Gelling Delivery System for the Treatment of Jawbone Infections

Abstract

Aim: A polymeric in situ gelling delivery system for localized and sustained delivery to jawbone infections was developed. Materials & methods: In situ gelling delivery systems were prepared using either Poly(dl-lactic acid) or chitosan and Pluronic F127/Pluronic F68. Metronidazole nanoparticles were prepared using poly(dl-lactide-co-glycolide) or chitosan. Poly(dl-lactide-co-glycolide) was used for microparticles. Particles were characterized for size, charge and morphology. Results: Viscosity and yield stress of the gels were 0.4 Pa.s and 2 Pa, respectively, with 70% cell viability over 72 h. Around 90% of loaded metronidazole was released at a sustained rate over 1 week. Conclusion: Use of appropriate amount of nano/microparticles in the gel resulted in a sustained release over a period of 1 week – needed for jawbone infection.

Advances in drug delivery systems, challenges and future directions

“…The injectable drug delivery method is utilized to cross-link pluronic acid-modified hydrazide with aldehyde-modified cellulose derivatives such as hydroxypropylmethyl cellulose, carboxymethyl cellulose, and methylcellulose, among others. In order to avoid postoperative peritoneal adhesion, this in-situ forming gel has been used to reduce pelvic discomfort, bowel blockage, and infertility [ 96 , 97 ].…”

Sustained release of azithromycin from lipid liquid-crystalline nanoparticles laden in situ gel for the treatment of periodontitis: In vitro and efficacy study

“…Briefly, under non-physiological condition the in situ solution was filled in the 5 mL capacity syringe with 22 gauge needle. 36 The force required to release the first drop of solution out of the syringe was noted on gauge and the experiment was repeated three times.…”