Injectable mesoporous bioactive glass/sodium alginate hydrogel loaded with melatonin for intervertebral disc regeneration

Wu, Ruibang; Huang, Lian‐Hua; Xia, Qinghong; Liu, Zheng; Huang, Yong; Jiang, Yulin; Wang, Juehan; Ding, Hong; Zhu, Ce; Song, Yueming; Liu, Limin; Zhang, Li; Feng, Ganjun

doi:10.1016/j.mtbio.2023.100731

Cited by 11 publications

(11 citation statements)

References 62 publications

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“…PU is composed of isocyanate and urethane groups polymerized with hydroxyl macromolecules as the basic repeating unit and has good abrasion resistance, toughness, and corrosion resistance (Liu Y. et al, 2021;Jiang R. et al, 2023), which are advantages in the production of biomaterials for replacing IVDs or AFs. J. Hu et al developed a silk fibroin/polyurethane (SF/PU) hydrogel that is liquid or semiliquid prior to injection and undergose gelation in situ after injection into the intervertebral disc, forming a gel with outstanding mechanical properties as a prosthetic biomaterial for replacing the NP and enabling strong visualization on T2-weighted MRI images allowing it both to provide adequate mechanical support and can also be readily visualized during subsequent testing (Hu et al, 2012).…”

Section: Polyurethane (Pu)mentioning

confidence: 99%

“…In a recently reported paper, Y. Jiang et al investigated a hydrogel delivery system consisting of sodium alginate (SA), poly(N-isopropylacrylamide) (pNIPAAm), and silicate ceramics (SC), carrying NPCs and Mg 2+ (Jiang Y. et al, 2023). At human body temperature, pNIPAAm and SA form interpenetrating network (IPN) hydrogels in situ in the presence of temperature and Ca 2+ ions and encapsulate NPCs and Mg 2+ (Figure 4).…”

Section: Temperature Sensitive Hydrogels In the Treatment Of Ivddmentioning

confidence: 99%

“…Schematic showing the composition of the injectable self-contained SA/PNIPAAm hydrogel, its working principle and functionality (Jiang Y. et al, 2023) Frontiers in Cell and Developmental Biology frontiersin.org 5). The entire NHPH system has mechanical strength similar to that of IVDs, inhibits inflammation, and delivers slow-release growth factors that enhance chondrocyte differentiation, thereby promoting the regeneration of fibrocartilage tissue for the treatment of degenerative IVDs (Conley et al, 2023).…”

Section: Figurementioning

confidence: 99%

“…Y, Li et al prepared fucoidanfunctionalized gelatin methacryloyl microsphere(Fu@GelMA-MS) hydrogel microspheres, which were able to inhibit inflammation in the environment of IVDD and to reduce the inflammation of IVDD by activating nuclear factor erythroid 2-related factor (NRF2), inhibiting intracellular ROS and enhancing antioxidant enzymes to protect the ECM. The authors used a microfluidic device to (Jiang Y. et al, 2023) Frontiers in Cell and Developmental Biology frontiersin.org integrate fucoidan into GelMA hydrogel microspheres to form the Fu@GelMA hydrogel system. The system was used to culture NPCs, and the results demonstrated excellent ability to promote cell proliferation with high biocompatibility, and fucoidan sustained release for 38 days, showing excellent controlled drug release.…”

Section: Photosensitive Hydrogels In the Treatment Of Ivddmentioning

confidence: 99%

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Application and development of hydrogel biomaterials for the treatment of intervertebral disc degeneration: a literature review

Liu,

Zhao,

Guo

et al. 2023

Front. Cell Dev. Biol.

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Low back pain caused by disc herniation and spinal stenosis imposes an enormous medical burden on society due to its high prevalence and refractory nature. This is mainly due to the long-term inflammation and degradation of the extracellular matrix in the process of intervertebral disc degeneration (IVDD), which manifests as loss of water in the nucleus pulposus (NP) and the formation of fibrous disc fissures. Biomaterial repair strategies involving hydrogels play an important role in the treatment of intervertebral disc degeneration. Excellent biocompatibility, tunable mechanical properties, easy modification, injectability, and the ability to encapsulate drugs, cells, genes, etc. make hydrogels good candidates as scaffolds and cell/drug carriers for treating NP degeneration and other aspects of IVDD. This review first briefly describes the anatomy, pathology, and current treatments of IVDD, and then introduces different types of hydrogels and addresses “smart hydrogels”. Finally, we discuss the feasibility and prospects of using hydrogels to treat IVDD.

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Section: Polyurethane (Pu)mentioning

confidence: 99%

Section: Temperature Sensitive Hydrogels In the Treatment Of Ivddmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Section: Photosensitive Hydrogels In the Treatment Of Ivddmentioning

confidence: 99%

See 2 more Smart Citations

Application and development of hydrogel biomaterials for the treatment of intervertebral disc degeneration: a literature review

Liu,

Zhao,

Guo

et al. 2023

Front. Cell Dev. Biol.

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“…17,18 By concentrating and prolonging the residence of drugs within IVD tissues, NDDSs possess the capability to augment therapeutic outcomes and enhance the efficacy of treatment. [19][20][21][22][23] This review provides a succinct overview of the underlying pathogenic mechanisms implicated in the progression of IVDD and delineates the current constraints associated with existing treatment modalities. Furthermore, it elucidates the notable advancements achieved in the field of NDDSs therapy for IVDD.…”

Section: Introductionmentioning

confidence: 99%

The Emerging Roles of Nanocarrier Drug Delivery System in Treatment of Intervertebral Disc Degeneration-Current Knowledge, Hot Spots, Challenges and Future Perspectives

Hu,

Yang,

Liu

et al. 2024

DDDT

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Low back pain (LBP) is a common condition that has substantial consequences on individuals and society, both socially and economically. The primary contributor to LBP is often identified as intervertebral disc degeneration (IVDD), which worsens and leads to significant spinal problems. The conventional treatment approach for IVDD involves physiotherapy, drug therapy for pain management, and, in severe cases, surgery. However, none of these treatments address the underlying cause of the condition, meaning that they cannot fundamentally reverse IVDD or restore the mechanical function of the spine. Nanotechnology and regenerative medicine have made significant advancements in the field of healthcare, particularly in the area of nanodrug delivery systems (NDDSs). These approaches have demonstrated significant potential in enhancing the efficacy of IVDD treatments by providing benefits such as high biocompatibility, biodegradability, precise drug delivery to targeted areas, prolonged drug release, and improved therapeutic results. The advancements in different NDDSs designed for delivering various genes, cells, proteins and therapeutic drugs have opened up new opportunities for effectively addressing IVDD. This comprehensive review provides a consolidated overview of the recent advancements in the use of NDDSs for the treatment of IVDD. It emphasizes the potential of these systems in overcoming the challenges associated with this condition. Meanwhile, the insights and ideas presented in this review aim to contribute to the advancement of precise IVDD treatment using NDDSs.

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Bioactive Glass in Tissue Regeneration: Unveiling Recent Advances in Regenerative Strategies and Applications

Zhu,

Zhang,

Chang

et al. 2024

Advanced Materials

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Bioactive glass (BG) is a class of biocompatible, biodegradable, multifunctional inorganic glass materials, which is successfully used for orthopedic and dental applications, with several products already approved for clinical use. Apart from exhibiting osteogenic properties, BG is also known to be angiogenic and antibacterial. Recently, BG's role in immunomodulation has been gradually revealed. While the therapeutic effect of BG is mostly reported in the context of bone and skin‐related regeneration, its application in regenerating other tissues/organs, such as muscle, cartilage, and gastrointestinal tissue, has also been explored recently. The strategies of applying BG have also expanded from powder or cement form to more advanced strategies such as fabrication of composite polymer‐BG scaffold, 3D printing of BG‐loaded scaffold, and BG‐induced extracellular vesicle production. This review presents a concise overview of the recent applications of BG in regenerative medicine. Various regenerative strategies of BG will be first introduced. Next, the applications of BG in regenerating various tissues/organs, such as bone, cartilage, muscle, tendon, skin, and gastrointestinal tissue, will be discussed. Finally, summarizing clinical applications of BG for tissue regeneration will conclude, and outline future challenges and directions for the clinical translation of BG.

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Injectable mesoporous bioactive glass/sodium alginate hydrogel loaded with melatonin for intervertebral disc regeneration

Cited by 11 publications

References 62 publications

Application and development of hydrogel biomaterials for the treatment of intervertebral disc degeneration: a literature review

Application and development of hydrogel biomaterials for the treatment of intervertebral disc degeneration: a literature review

The Emerging Roles of Nanocarrier Drug Delivery System in Treatment of Intervertebral Disc Degeneration-Current Knowledge, Hot Spots, Challenges and Future Perspectives

Bioactive Glass in Tissue Regeneration: Unveiling Recent Advances in Regenerative Strategies and Applications

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