Injectable mesquite gum and carboxymethyl chitosan hydrogel using schiff base crosslinks: a versatile platform for drug delivery in wound care

Kumar, Jitendra; Purwar, Roli

doi:10.1007/s13233-024-00300-7

Macromol. Res.

2024

DOI: 10.1007/s13233-024-00300-7

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Injectable mesquite gum and carboxymethyl chitosan hydrogel using schiff base crosslinks: a versatile platform for drug delivery in wound care

Jitendra Kumar,

Roli Purwar

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Cited by 3 publications

References 39 publications

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Assessing rheological properties of oxidized Moringa oleifera gum and carboxymethyl chitosan‐based self‐healing hydrogel for additive manufacturing applications

Verma,

Kumar,

Pradhan

et al. 2024

Polymer Engineering & Sci

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Rheology plays a vital role in pneumatic three‐dimensional (3D) printing of hydrogels. This study investigates the rheological behavior of a novel self‐healing hydrogel (O‐MOG/CMCh) formed by a Schiff base crosslinking reaction between oxidized Moringa oleifera gum (O‐MOG), a biodegradable antimicrobial polysaccharide, and carboxymethyl chitosan (CMCh), a water‐soluble biocompatible chitosan derivative. Three hydrogel formulations were designed using 5% w/v of CMCh with varied concentrations of O‐MOG (3% w/v, 4% w/v, and 5% w/v) and evaluated through rheology analyses, including frequency sweeps, amplitude sweeps, oscillatory thixotropy, and gelation kinetics. These tests revealed that the material has shear thinning, self‐healing properties, a high linear viscoelastic region (LVE), and gel formation times (tgel) of 3.23–4.57 min. The hydrogel synthesized with 5% w/v of O‐MOG composition exhibited the best characteristics for printability based on rheological assessments, and this composition was used for further printing assessment, where bi‐layered 4 × 4 and 2 × 2 grids were successfully printed using 22 G (0.41 mm) and 23 G (0.34 mm) syringes. All the constructs had a printability index value of 1 ± 0.13 and spreading ratios <6.5, demonstrating the feasibility of employing the synthesized hydrogel as an acellular matrix via additive manufacturing.Highlights Self‐healing hydrogel was prepared by mixing the precursors through a cannula. Rheology was examined using standard tests for printability assessment. 3D printability was achieved using two different gauze syringes. Printability parameters were recorded and analyzed for the constructs.

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Assessing rheological properties of oxidized Moringa oleifera gum and carboxymethyl chitosan‐based self‐healing hydrogel for additive manufacturing applications

Verma,

Kumar,

Pradhan

et al. 2024

Polymer Engineering & Sci

View full text Add to dashboard Cite

show abstract

A Schiff base hydrogel of oxidized okra gum and carboxymethylated chitosan: a biocompatible and biodegradable injectable system for drug delivery in wound care

Kumar,

Purwar

2024

Colloid Polym Sci

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Preparation of self-healing pHEMA hydrogels using dynamic covalent crosslinkers

Choi,

Cho

2024

Macromol. Res.

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Injectable mesquite gum and carboxymethyl chitosan hydrogel using schiff base crosslinks: a versatile platform for drug delivery in wound care

Cited by 3 publications

References 39 publications

Assessing rheological properties of oxidized Moringa oleifera gum and carboxymethyl chitosan‐based self‐healing hydrogel for additive manufacturing applications

Assessing rheological properties of oxidized Moringa oleifera gum and carboxymethyl chitosan‐based self‐healing hydrogel for additive manufacturing applications

A Schiff base hydrogel of oxidized okra gum and carboxymethylated chitosan: a biocompatible and biodegradable injectable system for drug delivery in wound care

Preparation of self-healing pHEMA hydrogels using dynamic covalent crosslinkers

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