Injectable MMP1-sensitive microspheres with spatiotemporally controlled exosome release promote neovascularized bone healing

Recent advances in GelMA hydrogel transplantation for musculoskeletal disorders and related disease treatment

“…Exosomes have important roles in bone repair, including promoting stem cell migration and promoting angiogenesis. Yang et al [61] therefore designed an injectable MMP1-sensitive hydrogel microsphere mixed with a self-assembling peptide (KLDL-MMP1), GelMA and BMSC-Exos, which significantly promoted angiogenesis and bone repair. Sun et al [62] prepared a GelMA@eIm/ZIF-67 composite hydrogel, which can regulate and control the release of Co ions, and effectively promote the osteogenic differentiation of BMSCs and angiogenic activity of human umbilical vein endothelial cells (HUVECs).…”

Cyaonoside A-loaded composite hydrogel microspheres to treat osteoarthritis by relieving chondrocyte inflammation

“…Additionally, the expression of cartilage-related proteins in joint tissues was of concern. 66,67 Therefore, we examined the expression of COL-2 and MMP13 in articular cartilage by immunohistochemical experiments. As shown in Fig.…”

Stimuli-responsive dynamic hydrogels: design, properties and tissue engineering applications

“…Yang et al developed an injectable MMP1-sensitive hydrogel microsphere hydrogel (LDL-MMP1/GelMA) that could release exosomes in response to MMP1 expression. 230 In vitro and in vivo experiments demonstrated that the developed hydrogel could promote the migration and osteodifferentiation of BMSCs and recruit CD90 + stem cells via neovascularization. Similarly, the ultrasound triggered release of growth factors and the pH stimulated release of antibiotics, growth factors and cells using the dynamic behavior of hydrogels have also been demonstrated.…”