Injectable Nano‐Micro Composites with Anti‐bacterial and Osteogenic Capabilities for Minimally Invasive Treatment of Osteomyelitis

Lu, Guanghua; Zhao, Gang; Wang, Shen; Li, Hanqing; Yu, Qiang; Sun, Qi; Wang, Bo; Wei, Li; Fu, Zi; Zhao, Zhenyu; Yang, Linshan; Deng, Lianfu; Zheng, Xianyou; Cai, Ming; Lu, Min

doi:10.1002/advs.202306964

Cited by 9 publications

(2 citation statements)

References 86 publications

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“…Antibiotics remain a formidable weapon for treating clinical infections. , Customizing antibiotics for PSs enables for more precise targeting according to their antibacterial spectra. For example, Chen et al fabricated a nanocomposite of methylbenzene blue (MB)-loaded ZIF-8-PAA and silver nanoparticles (AgNPs), decorated with vancomycin (Van) and NH 2 -polyethylene glycol (Van/NH 2 –PEG) .…”

Section: Photodynamic Therapy-based Targeted Strategymentioning

confidence: 99%

Photochemical Strategies toward Precision Targeting against Multidrug-Resistant Bacterial Infections

Yu,

Wang,

Zhang

et al. 2024

ACS Nano

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Infectious diseases pose a serious threat and a substantial economic burden on global human and public health security, especially with the frequent emergence of multidrug-resistant (MDR) bacteria in clinical settings. In response to this urgent need, various photobased anti-infectious therapies have been reported lately. This Review explores and discusses several photochemical targeted antibacterial therapeutic strategies for addressing bacterial infections regardless of their antibiotic susceptibility. In contrast to conventional photobased therapies, these approaches facilitate precise targeting of pathogenic bacteria and/or infectious microenvironments, effectively minimizing toxicity to mammalian cells and surrounding healthy tissues. The highlighted therapies include photodynamic therapy, photocatalytic therapy, photothermal therapy, endogenous pigments-based photobleaching therapy, and polyphenols-based photo-oxidation therapy. This comprehensive exploration aims to offer updated information to facilitate the development of effective, convenient, safe, and alternative strategies to counter the growing threat of MDR bacteria in the future.

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Section: Photodynamic Therapy-based Targeted Strategymentioning

confidence: 99%

Photochemical Strategies toward Precision Targeting against Multidrug-Resistant Bacterial Infections

Yu,

Wang,

Zhang

et al. 2024

ACS Nano

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“…Simultaneously, calcium phosphate nanosheets were released from the gel pores to promote bonedefect repair. [25]…”

Section: Biomolecule-sensitive Drug Releasementioning

confidence: 99%

Recent Progress in Implantable Drug Delivery Systems

He,

Li,

Liu

et al. 2024

Advanced Materials

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In recent years, tremendous effort has been devoted to developing platforms, such as implantable drug delivery systems (IDDSs), with temporally and spatially controlled drug release capabilities and improved adherence. IDDSs have multiple advantages: i) the timing and location of drug delivery can be controlled by patients using specific stimuli (light, sound, electricity, magnetism, etc.). Some intelligent “closed‐loop” IDDS can even realize self‐management without human participation. ii) IDDSs enable continuous and stable delivery of drugs over a long period (months to years) and iii) to administer drugs directly to the lesion, thereby help reduce dosage and side effects. iv) IDDSs enable personalized drug delivery according to patient needs. The high demand for such systems has prompted scientists to make efforts to develop intelligent IDDS. In this review, we detail several common stimulus‐responsive mechanisms including endogenous (e.g., pH, reactive oxygen species, proteins, etc.) and exogenous stimuli (e.g., light, sound, electricity, magnetism, etc.). Besides, several types of IDDS reported in recent years are reviewed, including various stimulus‐responsive systems based on the above mechanisms, radio frequency‐controlled IDDS, “closed‐loop” IDDS, self‐powered IDDS, etc. Finally, the advantages and disadvantages of various IDDS, bottleneck problems, and possible solutions are analyzed to provide directions for subsequent research.This article is protected by copyright. All rights reserved

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Ternary Thermosensitive Hydrogel‐Encapsulated Macrolactam Heneicosapeptide Eliminates Epidermal Multidrug‐Resistant Bi‐Microbial Colonization

Zeng,

Zhang,

et al. 2024

Adv Funct Materials

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Superbug epidemic has rendered antibiotic therapeutics increasingly ineffective. Worse still, there are few applicable medication regimens for polymicrobial infections caused by two or more multidrug‐resistant bacteria. Herein, a panel of antibacterial cyclic peptides are designed and synthesized and the lead compound cyclo‐zp80r shows favorable activities against a broad spectrum of bacteria. Encouragingly, it exhibited a strong bactericidal effect against two important epidermic species Pseudomonas aeruginosa and Staphylococcus aureus for both single‐ and co‐infections. The peptide cyclo‐zp80r is proposed to destroy the membrane structures of both Gram‐negative and Gram‐positive bacteria, inducing a variety of physiological disorders. To better adapt to topical administration of this novel antibacterial agent, a hydrogel formulation consisting of poloxamer 407, poloxamer 188, and hyaluronic acid is optimized. This ternary hydrogel system is able to form in situ gel at skin temperature. Encapsulated peptide molecules are released steadily in both human skin ex vivo model and mouse wound in vivo model to treat bi‐microbial infection. This work systematically investigates the design, synthesis, antibacterial mechanism of a novel cyclic peptide, and its drug delivery strategy for topical wound infection, offering a promising therapeutics to treat multidrug‐resistant polymicrobial wound infections.

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Injectable Nano‐Micro Composites with Anti‐bacterial and Osteogenic Capabilities for Minimally Invasive Treatment of Osteomyelitis

Cited by 9 publications

References 86 publications

Photochemical Strategies toward Precision Targeting against Multidrug-Resistant Bacterial Infections

Photochemical Strategies toward Precision Targeting against Multidrug-Resistant Bacterial Infections

Recent Progress in Implantable Drug Delivery Systems

Ternary Thermosensitive Hydrogel‐Encapsulated Macrolactam Heneicosapeptide Eliminates Epidermal Multidrug‐Resistant Bi‐Microbial Colonization

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