Injectable nanofiber-polysaccharide self-healing hydrogels for wound healing

Xuan, Hongyun; Wu, Shuyuan; Fei, Simiao; Li, Biyun; Yang, Yumin; Yuan, Huihua

doi:10.1016/j.msec.2021.112264

Cited by 62 publications

(22 citation statements)

References 44 publications

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“…Due to the low mechanical strength of hydrogel, it is easily damaged during application ( Xuan et al, 2021 ). The development of self-healing ability is crucial for hydrogel patches.…”

Section: Structure Of Hydrogels For Wound Healingmentioning

confidence: 99%

“…In addition, functional hydrogels can be obtained through rational design and preparation. Among them, injectable in-situ moldable hydrogels are gaining attention, which can be directly applied to irregular wounds ( Xuan et al, 2021 ). A plain hydrogel is often not effective enough in repairing skin wounds by only serving as a covering material.…”

Section: Introductionmentioning

confidence: 99%

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Rational Design and Preparation of Functional Hydrogels for Skin Wound Healing

et al. 2022

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Skin wound healing often contains a series of dynamic and complex physiological healing processes. It is a great clinical challenge to effectively treat the cutaneous wound and regenerate the damaged skin. Hydrogels have shown great promise for skin wound healing through the rational design and preparation to endow with specific functionalities. In the mini review, we firstly introduce the design and construction of various types of hydrogels based on their bonding chemistry during cross-linking. Then, we summarize the recent research progress on the functionalization of bioactive hydrogel dressings for skin wound healing, including anti-bacteria, anti-inflammatory, tissue proliferation and remodeling. In addition, we highlight the design strategies of responsive hydrogels to external physical stimuli. Ultimately, we provide perspectives on future directions and challenges of functional hydrogels for skin wound healing.

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“…Due to the low mechanical strength of hydrogel, it is easily damaged during application ( Xuan et al, 2021 ). The development of self-healing ability is crucial for hydrogel patches.…”

Section: Structure Of Hydrogels For Wound Healingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Rational Design and Preparation of Functional Hydrogels for Skin Wound Healing

et al. 2022

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“…A hydrogel using aldehyde functionalized sodium alginate with the help of Schiff base reaction and carboxymethyl chitosan (CS) was designed by Xuan et al Short nanofibers of carboxymethyl-functionalized polymethyl methacrylate (PMAA) were made from sodium hydroxide-treated polymethyl methacrylate nanofibers and added to a CS solution. The nanofiber hydrogels depicted excellent self-healing action and significantly facilitated wound healing [ 212 ]. Injectable hydrogels are the other important hydrogel category that are very advantageous for skin tissue engineering, but due to their incompatibility of required hair follicle formation or induced infection, the antibacterial hydrogel was designed using Ag29 nanoclusters, mangiferin, and chitosan molecules for wound healing.…”

Section: Potential Applications Of Hydrogel In the Biomedical Sectormentioning

confidence: 99%

Drug Delivery Strategies and Biomedical Significance of Hydrogels: Translational Considerations

et al. 2022

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Hydrogels are a promising and attractive option as polymeric gel networks, which have immensely fascinated researchers across the globe because of their outstanding characteristics such as elevated swellability, the permeability of oxygen at a high rate, good biocompatibility, easy loading, and drug release. Hydrogels have been extensively used for several purposes in the biomedical sector using versatile polymers of synthetic and natural origin. This review focuses on functional polymeric materials for the fabrication of hydrogels, evaluation of different parameters of biocompatibility and stability, and their application as carriers for drugs delivery, tissue engineering and other therapeutic purposes. The outcome of various studies on the use of hydrogels in different segments and how they have been appropriately altered in numerous ways to attain the desired targeted delivery of therapeutic agents is summarized. Patents and clinical trials conducted on hydrogel-based products, along with scale-up translation, are also mentioned in detail. Finally, the potential of the hydrogel in the biomedical sector is discussed, along with its further possibilities for improvement for the development of sophisticated smart hydrogels with pivotal biomedical functions.

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“…For example, starch nanofibers prepared by crosslinking method have the advantages of controllable sustained release and good biocompatibility. 153 Xuan et al 154 prepared an injectable nanofiber polysaccharide self-healing hydrogel, which can significantly promote wound healing.…”

Section: Biological Nanomaterials For Skin Wound Repairmentioning

confidence: 99%

Recent Advances in Nano-Formulations for Skin Wound Repair Applications

Lin¹,

Chen²,

Liu³

et al. 2022

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Skin injuries caused by accidents and acute or chronic diseases place a heavy burden on patients and health care systems. Current treatments mainly depend on preventing infection, debridement, and hemostasis and on supplementing growth factors, but patients will still have scar tissue proliferation or difficulty healing and other problems after treatment. Conventional treatment usually focuses on a single factor or process of wound repair and often ignores the influence of the wound pathological microenvironment on the final healing effect. Therefore, it is of substantial research value to develop multifunctional therapeutic methods that can actively regulate the wound microenvironment and reduce the oxidative stress level at the wound site to promote the repair of skin wounds. In recent years, various bioactive nanomaterials have shown great potential in tissue repair and regeneration due to their properties, including their unique surface interface effect, small size effect, enzyme activity and quantum effect. This review summarizes the mechanisms underlying skin wound repair and the defects in traditional treatment methods. We focus on analyzing the advantages of different types of nanomaterials and comment on their toxicity and side effects when used for skin wound repair.

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Injectable nanofiber-polysaccharide self-healing hydrogels for wound healing

Cited by 62 publications

References 44 publications

Rational Design and Preparation of Functional Hydrogels for Skin Wound Healing

Rational Design and Preparation of Functional Hydrogels for Skin Wound Healing

Drug Delivery Strategies and Biomedical Significance of Hydrogels: Translational Considerations

Recent Advances in Nano-Formulations for Skin Wound Repair Applications

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