Injectable network biomaterials via molecular or colloidal self-assembly

Sahoo, Jugal Kishore; VandenBerg, Michael A.; Webber, Matthew J.

doi:10.1016/j.addr.2017.11.005

Cited by 71 publications

(64 citation statements)

References 328 publications

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“…One feature that arises from the design of supramolecular hydrogels is that the dynamic and reversible physical cross‐linking afforded by host–guest recognition leads to materials wherein cross‐links can rupture and reform with no loss of mechanical properties. This feature lends itself to obvious application in preparing injectable materials . Such properties are often characterized using step‐strain rheology experiments, with a high strain (e.g., 200–500%) mimicking the case where pressure is applied to a formed hydrogel in the course of extrusion through a needle.…”

Section: Key Properties Of Host–guest Supramolecular Hydrogels In Biomentioning

confidence: 99%

“…The use of molecular recognition or dynamic covalent bonds results in polymer architectures that are often similar to that produced by traditional covalent chemical cross‐linking, with the exception that these interactions break and reform on experimentally relevant timescales, allowing the materials to evolve over time or heal in response to mechanical perturbations. There are many demonstrated applications for the use of supramolecular hydrogels as biomaterials for drug delivery, tissue engineering, and regenerative medicine …”

Section: Introductionmentioning

confidence: 99%

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Dynamic Hydrogels from Host–Guest Supramolecular Interactions

Mantooth

Munoz‐Robles

Webber

2018

Macromolecular Bioscience

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129

175

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Hydrogel biomaterials are pervasive in biomedical use. Applications of these soft materials range from contact lenses to drug depots to scaffolds for transplanted cells. A subset of hydrogels is prepared from physical cross‐linking mediated by host–guest interactions. Host macrocycles, the most recognizable supramolecular motif, facilitate complex formation with an array of guests by inclusion in their portal. Commonly, an appended macrocycle forms a complex with appended guests on another polymer chain. The formation of poly(pseudo)rotaxanes is also demonstrated, wherein macrocycles are threaded by a polymer chain to give rise to physical cross‐linking by secondary non‐covalent interactions or polymer jamming. Host–guest supramolecular hydrogels lend themselves to a variety of applications resulting from their dynamic properties that arise from non‐covalent supramolecular interactions, as well as engineered responsiveness to external stimuli. These are thus an exciting new class of materials.

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Section: Key Properties Of Host–guest Supramolecular Hydrogels In Biomentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dynamic Hydrogels from Host–Guest Supramolecular Interactions

Mantooth

Munoz‐Robles

Webber

2018

Macromolecular Bioscience

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129

175

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“…Noncovalent polymeric hydrogels are built up by reversible non‐covalent interactions that are often constantly in a dynamic state of breaking and reforming or in a poised state for breaking once the correct stimuli is applied . Therefore, they exhibit several interesting macroscale properties as presented in Figure .…”

Section: Key Features Of Noncovalent Polymeric Hydrogelsmentioning

confidence: 99%

A Recent Perspective on Noncovalently Formed Polymeric Hydrogels

Ke-min

Liow

Karim

et al. 2018

The Chemical Record

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Chemically crosslinked covalent hydrogels form a permanent and often strong network, and have been extensively used so far in drug delivery and tissue engineering. However, it is more difficult to induce dynamic and highly tunable changes in these hydrogels. Noncovalently formed hydrogels show promise as inherently reversible systems with an ability to change in response to dynamic environments, and have garnered strong interest recently. In this Personal Account, we elucidate a few key attractive properties of noncovalent hydrogels and describe recent developments in hydrogels crosslinked using various different noncovalent interactions. These hydrogels offer huge control for modulating material properties and could be more relevant mimics for biological systems.

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“…However, conventional permanently hydrogels with extensively high crosslinking density are typically more elastic rather than viscoelastic, and cannot adapt the local environmental complexity of bone defects, i.e., to accommodate the irregular structure and topography of the defects, to replicate the mechanical signals of normal ECM, and to withstand the external forces resulting from regular physiological activities . To overcome these limitations, hydrogels with local adaptability and long‐term bulk stability have emerged as attractive biomaterials, which are typically formed by reversible interactions (e.g., electrostatic interactions, hydrophilic/hydrophobic interactions, hydrogen bonds, guest–host interactions) . As the term “adaptability” interpreted as the ability to withstand the complex mechanical environment and irregular shape, these adaptable hydrogels have shown desired viscoelasticity including shear‐thinning and self‐healing behavior resulting from the reversibility of physical linkage within the network .…”

Section: Introductionmentioning

confidence: 99%

“…As the term “adaptability” interpreted as the ability to withstand the complex mechanical environment and irregular shape, these adaptable hydrogels have shown desired viscoelasticity including shear‐thinning and self‐healing behavior resulting from the reversibility of physical linkage within the network . However, these adaptable hydrogels have shown rather poor mechanical strength due to intrinsic feature of weak reversible bonds, thus restricting their widespread applications as biomaterials to spatially fill the bone defect rather than to substitute the defective load‐bearing bones . Therefore, it still remains a challenge to develop hydrogel biomaterials that are adaptable to the local structural and mechanical environment of bone defects.…”

Section: Introductionmentioning

confidence: 99%

Gelatin Nanoparticle‐Injectable Platelet‐Rich Fibrin Double Network Hydrogels with Local Adaptability and Bioactivity for Enhanced Osteogenesis

Chen

Yuan

et al. 2020

Adv Healthcare Materials

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Bone healing is a dynamic process regulated by biochemical signals such as chemokines and growth factors, and biophysical signals such as topographical and mechanical features of extracellular matrix or mechanical stimuli. Hereby, a mechanically tough and bioactive hydrogel based on autologous injectable platelet‐rich fibrin (iPRF) modified with gelatin nanoparticles (GNPs) is developed. This composite hydrogel demonstrates a double network (DN) mechanism, wherein covalent network of fibrin serves to maintain material integrity, and self‐assembled colloidal network of GNPs dissipates force upon loading. A rabbit sinus augmentation model is used to investigate the bioactivity and osteogenesis capacity of the DN hydrogels. The DN hydrogels adapt to the local environmental complexity of bone defects, i.e., accommodate the irregular shape of the defects and withstand the pressure formed in the maxillary sinus during animal's respiration process. The DN hydrogel is also demonstrated to absorb and prolong the release of the bioactive growth factors stemming from iPRF, which could have contributed to the early angiogenesis and osteogenesis observed inside the sinus. This adaptable and bioactive DN hydrogel can achieve enhanced bone regeneration in treating complex bone defects by maintaining long‐term bone mass and withstanding the functional mechanical stimuli.

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Injectable network biomaterials via molecular or colloidal self-assembly

Cited by 71 publications

References 328 publications

Dynamic Hydrogels from Host–Guest Supramolecular Interactions

Dynamic Hydrogels from Host–Guest Supramolecular Interactions

A Recent Perspective on Noncovalently Formed Polymeric Hydrogels

Gelatin Nanoparticle‐Injectable Platelet‐Rich Fibrin Double Network Hydrogels with Local Adaptability and Bioactivity for Enhanced Osteogenesis

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