Injectable Orthobiologics for the Treatment of Subchondral Insufficiency Fractures of the Knee (SIFK) and Related Pathogenic Processes

Osteonecrosis

“…Postarthroscopic osteonecrosis appears to have the same pathology, and LaPrade desires to list both conditions under the acronym SIFK 25 . Treatment of SIFK is relatively new, and injectable orthobiologics such as platelet-rich plasma, concentrates of bone marrow aspirates, and also calcium phosphate have been tried, but long-term effectiveness has yet to be determined 26 . In one study, nearly 1/3 of patients needed a total knee arthroplasty; these patients were older and tended to have baseline arthritis, and pathology was mostly medial 27 .…”