Injectable polyaniline nanorods/alginate hydrogel with AAV9-mediated VEGF overexpression for myocardial infarction treatment

Wu, Can; Zhang, Yuxin; Xu, Yuanyuan; Long, Linyu; Hu, Xuefeng; Zhang, Jieyu; Wang, Yunbing

doi:10.1016/j.biomaterials.2023.122088

Cited by 30 publications

(7 citation statements)

References 49 publications

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“…Injectable alginate hydrogel formulations of MSCs improved cell retention rates up to 50–62% [ 179 , 209 ], and promoted enhanced cell proliferation and contractile function [ 195 , 210 , 211 ]. Notably, crosslinked alginate hydrogel has mechanical properties closely similar to the cardiac tissue [ 212 ] which further emphasize its suitability for the treatment of MI. Interestingly, as the post-infarction environment undergoes recovery, the concentration of local calcium ions decreases.…”

Section: Cell Encapsulation Techniquesmentioning

confidence: 99%

Recent Advances in Alginate-Based Hydrogels for Cell Transplantation Applications

Kavand,

Noverraz,

Gerber-Lemaire

2024

Pharmaceutics

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With its exceptional biocompatibility, alginate emerged as a highly promising biomaterial for a large range of applications in regenerative medicine. Whether in the form of microparticles, injectable hydrogels, rigid scaffolds, or bioinks, alginate provides a versatile platform for encapsulating cells and fostering an optimal environment to enhance cell viability. This review aims to highlight recent studies utilizing alginate in diverse formulations for cell transplantation, offering insights into its efficacy in treating various diseases and injuries within the field of regenerative medicine.

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Section: Cell Encapsulation Techniquesmentioning

confidence: 99%

Recent Advances in Alginate-Based Hydrogels for Cell Transplantation Applications

Kavand,

Noverraz,

Gerber-Lemaire

2024

Pharmaceutics

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“…Injectable hydrogel is an important material widely used in cardiac tissue engineering to provide mechanical support to the heart by intracardiac injection, which in turn improves the compliance of the ventricular wall. In addition, the injectable hydrogel is an excellent platform for sustained drug release for myocardial tissue repair, thus promoting myocardial regeneration and repair [14][15][16]. And they can protect EVs from rapid clearance and provide a microenvironment optimized for cell proliferation in damaged tissues when injected into myocardium.…”

Section: Introductionmentioning

confidence: 99%

Silk fibroin and hydroxypropyl cellulose composite injectable hydrogel-containing extracellular vesicles for myocardial infarction repair

Hua,

He,

et al. 2024

Biomed. Phys. Eng. Express

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Extracellular vesicles (EVs) have been recognized as one of the promising specific drugs for myocardial infarction (MI) prognosis. Nevertheless, low intramyocardial retention of EVs remains a major impediment to their clinical application. In this study, we developed a silk fibroin/hydroxypropyl cellulose (SF/HPC) composite hydrogel combined with AC16 cell-derived EVs targeted modification by folic acid for the treatment of acute myocardial infarction repair. EVs were functionalized by distearoylphosphatidyl ethanolamine-polyethylene glycol (DSPE-PEG-FA) via noncovalent interaction for targeting and accelerating myocardial infarction repair. In vitro, cytocompatibility analyses revealed that the as-prepared hydrogels had excellent cell viability by MTT assay and the functionalized EVs had higher cell migration by scratch assay. In vivo, the composite hydrogels can promote myocardial tissue repair effects by delaying the process of myocardial fibrosis and promoting angiogenesis of infarct area in MI rat model.

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“…[10][11][12] And finally, in the third approach, the PANI particles are dispersed in a hydrogel precursor and the composite turns into a gel. [13][14][15] A myriad of research works has integrated PANI with a hydrogel matrix via the aforesaid approaches.…”

Section: Introductionmentioning

confidence: 99%

Developing a ternary conductive hydrogel of polyacrylamide, polyaniline, and carbon nanotube: A potential chemiresistive gas sensor

Peykari,

Pourmahdian

2023

Journal of Composite Materials

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Over the past few years, conductive hydrogels have received increasing attention for numerous electronic applications because of the concurrent provision of electrical conductivity, flexibility, and conformability. In the present study, a polyaniline-based conductive hydrogel was synthesized. Carbon nanotubes (CNTs) were associated with the hydrogel to impart higher electrical conductivity to the hydrogel, and ternary composites of polyacrylamide (PAM), polyaniline (PANI), and CNT were developed. To fulfill this, at first, CNT surface was decorated with carboxyl functionalities, and the carboxyl decorated CNT was included into the composition in two manners: firstly, CNTs were included during acrylamide polymerization, whereas in the second manner, CNTs were incorporated during aniline polymerization. The composite hydrogels' chemical, swelling, morphological, and electrical properties were evaluated. The experimental results corroborated that in the latter case, abundant intermolecular interactions were developed between the PANI chains and the CNT surface. Moreover, the swelling value was increased by 9% comapred to the former case. In the former case, a porous microstructure and in the latter case a fibrous microstructure was dominated. And more importantly, the electrical conductivity of the hydrogel in the latter case was 104 folds higher than that in the former case. The ternary composition prepared with the latter manner was employed for sensing the ammonia gas, and the analyses unveiled that the hydrogel represents an appropriate response in the range of 10.43%–16.87% to various concentrations of the target gas and has the potential to be a thriving chemiresistive gas sensor.

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Injectable polyaniline nanorods/alginate hydrogel with AAV9-mediated VEGF overexpression for myocardial infarction treatment

Cited by 30 publications

References 49 publications

Recent Advances in Alginate-Based Hydrogels for Cell Transplantation Applications

Recent Advances in Alginate-Based Hydrogels for Cell Transplantation Applications

Silk fibroin and hydroxypropyl cellulose composite injectable hydrogel-containing extracellular vesicles for myocardial infarction repair

Developing a ternary conductive hydrogel of polyacrylamide, polyaniline, and carbon nanotube: A potential chemiresistive gas sensor

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