Injectable polypeptide-engineered hydrogel depot for amplifying the anti-tumor immune effect induced by chemo-photothermal therapy

Hou, Xiaolin; Dai, Xiang; Yang, Jie; Zhang, Bin; Zhao, Donghui; Li, Chaoqing; Yin, Zhongyuan; Zhao, Yuan‐Di; Liu, Bo

doi:10.1039/d0tb01370f

Cited by 39 publications

(34 citation statements)

References 33 publications

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“…The change in temperature can control the gel-sol transformation of thermosensitive hydrogels and release active factors for enhanced therapy [ 35 ]. Pedersen et al reported that a polyvinyl alcohol/gold nanorod (AuNR) hydrogel was heated to <50 °C under NIR irradiation and liquefied in 15–20 s, and the pulsed release model cargo of fluorescein isothiocyanate controlled by NIR irradiation was realized successfully [ 36 ].…”

Section: Introductionmentioning

confidence: 99%

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

Zhang

Tan

et al. 2021

Polymers

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Photothermal treatment (PTT) is a promising strategy to deal with multidrug-resistant bacteria infection and promote tissue regeneration. Previous studies demonstrated that hyperthermia can effectively inhibit the growth of bacteria, whereas mild heat can promote cell proliferation, further accelerating wound healing and bone regeneration. Especially, hydrogels with photothermal properties could achieve remotely controlled drug release. In this review, we introduce a photothermal agent hybrid in hydrogels for a photothermal effect. We also summarize the potential mechanisms of photothermal hydrogels regarding antibacterial action, angiogenesis, and osteogenesis. Furthermore, recent developments in photothermal hydrogels in wound healing and bone regeneration applications are introduced. Finally, future application of photothermal hydrogels is discussed. Hydrogels with photothermal effects provide a new direction for wound healing and bone regeneration, and this review will give a reference for the tissue engineering.

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Section: Introductionmentioning

confidence: 99%

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

Zhang

Tan

et al. 2021

Polymers

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“…Basically, the physical properties, such as viscosities of hydrogel aqueous solutions, swelling abilities, and mechanical properties after shaping, can be altered to some extent [ 100 , 116 ]. Furthermore, these multifunctional features of hydrogels also provide excellent opportunities for manipulating these hydrogels on various engineering techniques, including 3D printing, microfluidic spinning, and co-coaxial extrusion technology [ [159] , [160] , [161] ].…”

Section: Hydrogels As the Artificial Microenvironmentmentioning

confidence: 99%

“…An impressive spectrum of cell biology, versatile hydrogels, and clinical pathology has enabled the formation of 3D tissue analogs with promoted vascularization. To date, an extensive study has demonstrated various organ types that can be mimicked by hydrogels, including but not limited to bone [ 77 , 95 , [163] , [164] , [165] ], kidney [ [52] , [53] , [54] ], liver [ [55] , [56] , [57] ], lung [ 160 , 166 , 167 ], muscle [ [58] , [59] , [60] , [61] ], and brain [ 138 , 168 ]. Ultimately, the generation of these reproducible and accurate 3D organoids has extended the downstream translational applications, including tissue regeneration ( Table 3 ), organ-on-chips ( Table 4 ), and drug screening ( Table 5 ).…”

Section: Potential Applicationsmentioning

confidence: 99%

“…An obvious and first strategy that should be considered directly is tissue transplantation [ 19 , 33 , 95 , 96 , 163 , 165 ]. The other effective approach that should be realized is the employment of the injectable vascularized microtissues for in situ tissue regeneration [ 19 , 84 , 85 , 104 , 121 , 151 , 160 , [169] , [170] , [171] , [172] ].…”

Section: Potential Applicationsmentioning

confidence: 99%

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Advances in hydrogel-based vascularized tissues for tissue repair and drug screening

Wang

Kankala

et al. 2022

Bioactive Materials

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The construction of biomimetic vasculatures within the artificial tissue models or organs is highly required for conveying nutrients, oxygen, and waste products, for improving the survival of engineered tissues in vitro . In recent times, the remarkable progress in utilizing hydrogels and understanding vascular biology have enabled the creation of three-dimensional (3D) tissues and organs composed of highly complex vascular systems. In this review, we give an emphasis on the utilization of hydrogels and their advantages in the vascularization of tissues. Initially, the significance of vascular elements and the regeneration mechanisms of vascularization, including angiogenesis and vasculogenesis, are briefly introduced. Further, we highlight the importance and advantages of hydrogels as artificial microenvironments in fabricating vascularized tissues or organs, in terms of tunable physical properties, high similarity in physiological environments, and alternative shaping mechanisms, among others. Furthermore, we discuss the utilization of such hydrogels-based vascularized tissues in various applications, including tissue regeneration, drug screening, and organ-on-chips. Finally, we put forward the key challenges, including multifunctionalities of hydrogels, selection of suitable cell phenotype, sophisticated engineering techniques, and clinical translation behind the development of the tissues with complex vasculatures towards their future development.

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“…For example, Hou et al used genetically engineered polypeptide hydrogel PC10ARGD as a sustained-release system that delivered Bestatin which is an immune adjuvant for mammary carcinoma treatment. The hydrogel serves as a drug delivery depot for sustained drug release of Bestatin, which further inhibits tumour metastases and microvessel formation but amplified T lymphocytes function ( Hou et al, 2020 ). Liu et al developed a smart hydrogel based on alginate, which hybridized with immunoadjuvant CpG oligonucleotide and conjugated with an adenosine triphosphate (ATP)-specific aptamer.…”

Section: Applications Of Hydrogels As Delivery Systems For Cancer Immunotherapymentioning

confidence: 99%

Hydrogel-By-Design: Smart Delivery System for Cancer Immunotherapy

Cui

Wang

et al. 2021

Front. Bioeng. Biotechnol.

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Immunotherapy has emerged as a promising strategy for cancer treatment, in which durable immune responses were generated in patients with malignant tumors. In the past decade, biomaterials have played vital roles as smart drug delivery systems for cancer immunotherapy to achieve both enhanced therapeutic benefits and reduced side effects. Hydrogels as one of the most biocompatible and versatile biomaterials have been widely applied in localized drug delivery systems due to their unique properties, such as loadable, implantable, injectable, degradable and stimulus responsible. Herein, we have briefly summarized the recent advances on hydrogel-by-design delivery systems including the design of hydrogels and their applications for delivering of immunomodulatory molecules (e.g., cytokine, adjuvant, checkpoint inhibitor, antigen), immune cells and environmental regulatory substances in cancer immunotherapy. We have also discussed the challenges and future perspectives of hydrogels in the development of cancer immunotherapy for precision medicine at the end.

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Injectable polypeptide-engineered hydrogel depot for amplifying the anti-tumor immune effect induced by chemo-photothermal therapy

Abstract: The immunosuppressive tumor microenvironment has caused great obstacles to tumor immunotherapy, especially less tumor-associated antigens released from tumor sites. Herein, Ag2S QD/DOX/Bestatin@PC10ARGD genetically engineered polypeptide hydrogel PC10ARGD as sustained-release material...

Cited by 39 publications

References 33 publications

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

Advances in hydrogel-based vascularized tissues for tissue repair and drug screening

Hydrogel-By-Design: Smart Delivery System for Cancer Immunotherapy

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