Injectable polysaccharide hydrogel embedded with hydroxyapatite and calcium carbonate for drug delivery and bone tissue engineering

Ren, Bowen; Chen, Xueyun; Du, Shoukang; Ma, Ye; Chen, Huinan; Yuan, Guoliang; Li, Jianliang; Xiong, Dangsheng; Tan, Huaping; Ling, Zhonghua; Chen, Yong; Hu, Xiaohong; Niu, Xiaohong

doi:10.1016/j.ijbiomac.2018.06.200

Cited by 172 publications

(103 citation statements)

References 34 publications

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“…The biocompatibility and viscoelastic properties of alginate-based hydrogel matrices combined with the osteoconductivity of CaP particles were beneficial for bone regeneration and showed promising results as minimally invasive bone-filler materials. Jiang et al [213], designed stratified OC grafts with multi-tissue regions, based on an agarose hydrogel matrix integrating composite microspheres of PLGA and 45S5 bioactive glass (BG). The authors observed the ability of producing three distinct yet continuous regions of cartilage, calcified cartilage, and bone-like matrices by the incorporation of the PLGA-BG composite that promoted chondrocytes mineralization in the interface and the formation of a mineralized matrix in the osteoblast-cultured bone-like region.…”

Section: Scaffolding Strategies For Tissue Engineering and Regenermentioning

confidence: 99%

Scaffolding Strategies for Tissue Engineering and Regenerative Medicine Applications

et al. 2019

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During the past two decades, tissue engineering and the regenerative medicine field have invested in the regeneration and reconstruction of pathologically altered tissues, such as cartilage, bone, skin, heart valves, nerves and tendons, and many others. The 3D structured scaffolds and hydrogels alone or combined with bioactive molecules or genes and cells are able to guide the development of functional engineered tissues, and provide mechanical support during in vivo implantation. Naturally derived and synthetic polymers, bioresorbable inorganic materials, and respective hybrids, and decellularized tissue have been considered as scaffolding biomaterials, owing to their boosted structural, mechanical, and biological properties. A diversity of biomaterials, current treatment strategies, and emergent technologies used for 3D scaffolds and hydrogel processing, and the tissue-specific considerations for scaffolding for Tissue engineering (TE) purposes are herein highlighted and discussed in depth. The newest procedures focusing on the 3D behavior and multi-cellular interactions of native tissues for further use for in vitro model processing are also outlined. Completed and ongoing preclinical research trials for TE applications using scaffolds and hydrogels, challenges, and future prospects of research in the regenerative medicine field are also presented.

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Section: Scaffolding Strategies For Tissue Engineering and Regenermentioning

confidence: 99%

Scaffolding Strategies for Tissue Engineering and Regenerative Medicine Applications

et al. 2019

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“…Alginate has been used to enable modified/extended release of an active drug within the body (Tønnesen and Karlsen, 2002) and as a component in the construction of capsules used for cellencapsulation. For cytotherapy, combined with chitosan, the mixture demonstrates high cell viability (Correia et al, 2013) and may be also combined with calcium carbonate to selectively trap of molecules on hydrophilic domains, or polyethylene glycol to protect the microcapsules from acidic environments such as gastric acid (Borvinskaya et al, 2018;Ren et al, 2018). These properties have enabled composites of alginate to be trialed in the treatment of degenerative diseases such as osteoarthritis (Wang et al, 2011).…”

Section: Drug Deliverymentioning

confidence: 99%

Plant-Derived Biomaterials: A Review of 3D Bioprinting and Biomedical Applications

et al. 2019

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The pursuit of appropriate, biocompatible materials is one of the primary challenges in translational bioprinting. The requirement to refine a biomaterial into a bioink places additional demands on the criteria for candidate biomaterials. The material must enable extrusion as a liquid bioink and yet be capable of maintaining its shape in the post-printing phase to yield viable tissues, organs and biological materials. Plant-derived biomaterials show great promise in harnessing both the natural strength of plant microarchitecture combined with their natural biological roles as supporters of cell growth. The aim of this review article is to outline the most widely used biomaterials derived from land plants and marine algae: nanocellulose, pectin, starch, alginate, agarose, fucoidan, and carrageenan, with an in-depth focus on nanocellulose and alginate. The properties that render these materials as promising bioinks for three dimensional bioprinting is herein discussed alongside their potential in 3D bioprinting for tissue engineering, drug delivery, wound healing, and implantable medical devices.

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“…The G ′ was greater than G ″ by approximately an order of magnitude for all of the three hydrogels over the entire range of frequency, which indicated the good stability of three‐dimension network in the gel system. [ 21 ] Interestingly, a slight elevation of elastic modulus of GelMA–BP@PDA‐0.15 was observed, which might be due to the hydrogen‐bond interaction between BP@PDA and GelMA polymer. Notably, increasing the amount of BP@PDA from 0.15 to 0.3 mg mL −1 did not further improve its mechanical properties but rather reduced the elastic modulus.…”

Section: Resultsmentioning

confidence: 99%

Black‐Phosphorus‐Incorporated Hydrogel as a Conductive and Biodegradable Platform for Enhancement of the Neural Differentiation of Mesenchymal Stem Cells

Yang

et al. 2020

Adv Funct Materials

127

115

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Conductive hydrogel scaffolds have important applications for electroactive tissue repairs. However, the development of conductive hydrogel scaffolds tends to incorporate nonbiodegradable conductive nanomaterials that will remain in the human body as foreign matters. Herein, a biodegradable conductive hybrid hydrogel is demonstrated based on the integration of black phosphorus (BP) nanosheets into the hydrogel matrix. To address the challenge of applying BP nanosheets in tissue engineering due to its intrinsic instability, a polydopamine (PDA) modification method is developed to improve the stability. Moreover, PDA modification also enhances interfacial bonding between pristine BP nanosheets and the hydrogel matrix. The incorporation of polydopamine-modified black phosphorous (BP@PDA) nanosheets into the gelatin methacryloyl (GelMA) hydrogels significantly enhances the electrical conductivity of the hydrogels and improves the cell migration of mesenchymal stem cells (MSCs) within the 3D scaffolds. On the basis of the gene expression and protein level assessments, the BP@PDAincorporated GelMA scaffold can significantly promote the differentiation of MSCs into neural-like cells under the synergistic electrical stimulation. This strategy of integrating biodegradable conductive BP nanomaterials within a biocompatible hydrogel provides a new insight into the design of biomaterials for broad applications in tissue engineering of electroactive tissues, such as neural, cardiac, and skeletal muscle tissues.

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Injectable polysaccharide hydrogel embedded with hydroxyapatite and calcium carbonate for drug delivery and bone tissue engineering

Cited by 172 publications

References 34 publications

Scaffolding Strategies for Tissue Engineering and Regenerative Medicine Applications

Scaffolding Strategies for Tissue Engineering and Regenerative Medicine Applications

Plant-Derived Biomaterials: A Review of 3D Bioprinting and Biomedical Applications

Black‐Phosphorus‐Incorporated Hydrogel as a Conductive and Biodegradable Platform for Enhancement of the Neural Differentiation of Mesenchymal Stem Cells

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