Injectable selenium-containing polymeric hydrogel formulation for effective treatment of myocardial infarction

Abstract

Myocardial infarction (MI) is a serious threat to people’s life and health, which is significantly hindered by effective treatment formulations. Interestingly, our recent endeavour of designing selenium-containing polymeric hydrogel has been experimentally proved to be helpful in combating inflammatory responses and treating MI. The design was inspired by selenium with anti-inflammatory and anti-fibrosis activities, and the formulation could also serve as a support of myocardial tissue upon the failure of this function. In details, an injectable selenium-containing polymeric hydrogel, namely, poly[di-(1-hydroxylyndecyl) selenide/polypropylene glycol/polyethylene glycol urethane] [poly(DH-SE/PEG/PPG urethane)], was synthesised by combining a thermosensitive PPG block, DH-Se (which has oxidation-reduction properties), and hydrophilic PEG segments. Based on the established mouse model of MI, this formulation was experimentally validated to effectively promote the recovery of cardiac function. At the same time, we confirmed by enzyme-linked immunosorbent assay, Masson staining and Western blotting that this formulation could inhibit inflammation and fibrosis, so as to significantly improve left ventricular remodelling. In summary, a selenium-containing polymeric hydrogel formulation analysed in the current study could be a promising therapeutic formulation, which can provide new strategies towards the effective treatment of myocardial infarction or even other inflammatory diseases.

Injectable hydrogel-based combination therapy for myocardial infarction: a systematic review and Meta-analysis of preclinical trials

“…A wide range of medications used in combination with hydrogel for the treatment of myocardial infarction includes natural bioactive drugs such as tanshin and colchicine [ 90 ], curcumin [ 134 ], compounds (NO [ 135 ], Se [ 136 ]), and various synthetic products. Bioactive drugs, including curcumin and quercetin, possess strong anti-inflammatory, anti-apoptotic, and tissue repair properties.…”

“…However, their limited solubility in water hinders efficient delivery through oral or traditional methods. In a study conducted by Cui Yang et al [ 136 ], Se-containing PEG-PPG hydrogels were utilized to reduce pro-inflammatory cytokine secretion, improve myocardial fibrosis, and enhance left ventricular remodeling.…”

Advances in the design, generation, and application of tissue-engineered myocardial equivalents

“…With inspiration from biological processes, several smart materials were generated by biofunctionalization or encapsulation to maximize the adhesion of specific cells and spatiotemporal control of the homing process ( Lai et al, 2014 ; Chang et al, 2022 ; He et al, 2022 ; Yang et al, 2022 ), facilitate delivery and imaging ( Sun et al, 2022 ), improve oxygenation ( Suvarnapathaki et al, 2023 ), as well as reduce oxidative stress and inflammation, regulate autophagy and/or ameliorate cardiac function ( Shilo et al, 2021 ; Fu et al, 2022 ; Guo et al, 2022 ; Wu et al, 2022 ).…”

Injectable Hydrogel-Based Combination Therapy for Myocardial Infarction: A Systematic Review and Meta-Analysis of Preclinical Trials

“…Medications used in tandem with hydrogel for myocardial infarction treatment span a broad spectrum, encompassing natural bioactive drugs (tanshin, colchicine [90], curcumin [133]), compounds (NO [134], Se [135]), and various synthetic products. Bioactive drugs, including curcumin and quercetin, exhibit potent anti-in ammatory, anti-apoptotic, and tissue repair properties.…”

“…However, their limited aqueous solubility hinders e cient delivery through oral or traditional methods. Cui Yang et al [135] employed Se-containing PEG-PPG hydrogels to diminish pro-in ammatory cytokine secretion, ameliorate myocardial brosis, and enhance left ventricular remodeling.…”