Injectable Shear-Thinning Fluorescent Hydrogel Formed by Cellulose Nanocrystals and Graphene Quantum Dots

Khabibullin, Amir; Alizadehgiashi, Moien; Khuu, Nancy; Prince, Elisabeth

doi:10.1021/acs.langmuir.7b02906

Cited by 102 publications

(91 citation statements)

References 54 publications

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“…Extrusion can be used for the fabrication of homogeneous and heterogeneous polymer sheets for cell culture and studies of chemotaxis, as well as the preparation of conductive materials, sensors, and materials for anti‐counterfeiting applications . Furthermore, extrusion of polymer sheets with anisotropic properties (governed by flow‐induced alignment of structural components) has applications in tissue engineering, since anisotropy may be important for cell guidance, proliferation, and differentiation …”

Section: Resultsmentioning

confidence: 99%

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3D‐Printed Microfluidic Devices for Materials Science

Alizadehgiashi

Gevorkian

Tebbe

et al. 2018

Adv Materials Technologies

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requires rapid prototyping, iteration, and optimization of MF devices, the cost and the time of their fabrication are important considerations for the outcome of this work. [16] In addition, MF devices with complex designs are often required for achieving sufficient mixing of the ingredients or for generating spatially heterogeneous (patterned) materials. Another requirement is the device stability and integrity during its operation: it should withstand pressure, wear, and exposure to solvents and reagents without feature distortion, cracking, or delamination, particularly important when many-hour MF device operation is expected.Over the past decades, MF devices have been fabricated in silicon, glass, metals, and polymers. [17][18][19] Currently, soft lithography is the main fabrication method of MF devices in polydimethylsiloxane (PDMS). This method offers high fidelity and resolution down to the sub-micrometer size range, however PDMS swells in many organic solvents, absorbs amino-containing reagents, delaminates under high pressures, and has high gas permeability. [19][20][21][22] Injection molding and hot embossing microfabrication offer the capability of high-volume device production from chemically resistant polymers, [23] however high cost of molds or stamps and the challenge in the fabrication of devices with complex designs limit the applications of these techniques. Fabrication in silicon provides high thermal conductivity of MF devices, however this method is expensive and labor-and time-consuming. Similarly, fabrication of MF devices in glass is cost-intensive and utilizes hazardous agents such as hydrofluoric acid. [17] Recently, 3D printing has offered a cost-, time-, and laborefficient method for one-step fabrication of 3D objects with complex designs. [19,[24][25][26] This method provides the capability to fabricate MF devices with features that are impossible or challenging to implement by other fabrication techniques, as well as the ability of rapid device prototyping. [27] Prior to the fabrication, the desired device design is implemented in a CAD file, which is then transferred to the printer. The device is then printed in a layer-by-layer fashion. [26] Microfluidic mixers, [28,29] microreactors, [30] and droplet generators [31] have been fabricated in poly(propylene), [30] poly(lactic acid), [32] photocurable resins, [25,28,29] and glass. [33] The utilization of 3D-printed MF devices for materials synthesis and assembly is still in its infancy. [19,26] To the best of our knowledge, 3D-printed MF reactors have been used only the solution-based synthesis of gold and Prussian blue nanoparticles (NPs), [30,34] and their use for extrusion and spraying Microfluidics (MFs) has emerged as a valuable and in some cases, unique platform for the synthesis and assembly of inorganic and polymeric materials. 3D printing enables time-, labor-, and cost-efficient prototyping of MF devices, their durability during operation, and the ability to implement complex designs, however the applications of 3D-printed M...

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Section: Resultsmentioning

confidence: 99%

“…The stripe‐patterned sheets can be used for growth of stem cells, for studies of chemotaxis, the fabrication of conductive patterns, sensors, functional tattoo printing, anti‐counterfeiting, and coding …”

Section: Resultsmentioning

confidence: 99%

3D‐Printed Microfluidic Devices for Materials Science

Alizadehgiashi

Gevorkian

Tebbe

et al. 2018

Adv Materials Technologies

Self Cite

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“…Nevertheless, all of them emerged a pronounced shear‐thinning flow behavior, which is required for extrusion‐based 3D printing because it can facilitate their flow through a nozzle. [ 27 ] Furthermore, the rheology investigations were elucidated through storage modulus (G′) and loss modulus (G″) (Figure 1c). Varying the M‐PDMS amount and plotting the stress from 0.1 to 1000 Pa indicate that the G′ and G″ were increased remarkably with the increase of M‐PDMS, and with the content of 10 wt%, the G′ and G″ became the almost equal values.…”

Section: Methodsmentioning

confidence: 99%

Facile Photo and Thermal Two‐Stage Curing for High‐Performance 3D Printing of Poly(Dimethylsiloxane)

Jiang

Zhang

et al. 2020

Macromol. Rapid Commun.

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moderate elastic modulus) for extrusion with the techniques of inkjet printing and direct ink writing (DIW). Unfortunately, most of the common PDMS precursors have neither light responsive (no unsaturated bonds or groups for curing or cross-linking) nor moderate viscosity (too low viscosity to support the deposited filaments). Recent advances have been exploited to solve these issues to achieve PDMS 3D printing. For example, Feinberg et al. demonstrated the 3D printing hydrophobic Sylgard-184 prepolymer resins within a hydrophilic Carbopol gel support via freeform reversible embedding. [19] Bhattacharjee and co-workers realized desktop-stereolithography 3D printing of PDMS based on commercially available methacrylated PDMS. [20] Very recently, Qin et al. developed a methacrylated PDMS that can realize the ultrafast and continuous fabrication of the PDMS membrane by UV induced polymerization. [21] Despite of the 3D objects obtained in the previous efforts, there are still some blemishes including the difficulty to build complicated 3D architectures and the requirement of fussy procedures for manually removing supporting bath. [22] Also, most of them are not compatible to the commercially available PDMSs, and moreover these tailor-made PDMSs for 3D printing usually exhibited quite poor mechanical performances with the tensile strength of less than ≈0.7 MPa, which is one order decrease, [6,20] and the elastic modulus of less than 0.9 MPa. [19] Therefore, there are still challenges to achieve 3D printing of PDMS and devices, especially with a universal approach and based on commercial materials.To address, we propose a photo/thermal two-stage curing strategy under the premise of excellent rheological behaviors, i.e., 3D printing with ultraviolet-assisted direct ink writing (UV-DIW) followed by thermal cross-linking, based on a commercial material of Sylgard-184. Typically, a commercial methacrylated prepolymer ((Methacryloxypropyl)methylsiloxane-dimethylsiloxane copolymer, M-PDMS, Scheme 1) was mixed with the base and curing agent of Sylgard-184 resulting in a photosensitive PDMS (pPDMS). Due to the UV curing capability, the pPDMS exhibits excellent 3D printability because of the adjustment of the viscosity and elastic modulus during the extruded process with the UV-DIW technology. [23,24] The filament diameter of ≈100 µm and the layer thickness of ≈80 µm can be achieved, and also architectures with high complexity including hollow cylinders, lattices, cellular structures, and Three-dimensional (3D) printing of poly(dimethylsiloxane) (PDMS) is realized with a two-state curing strategy, i.e., photocuring for additively manufacturing high-precision architectures followed by thermal cross-linking for high-performance objects, taking Sylgard-184 as an example. In the mixture of base and curing agent of Sylgard-184, the photocuring ingredient methacrylated PDMS is incorporated to form hybrid inks with not only highefficiency UV curing ability but also moderate rheological properties for 3D printing. The inks are then used...

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“…They also showed a photoluminescence behavior when excited at 365 nm, due to the inherent properties of the graphene quantum dots. They had an anisotropic structure, like the morphology of tissues in the human body like cornea, striated muscles, cartilage, etc., and this is crucial for cell guidance, mass transport, proliferation, and differentiation …”

Section: Hydrogels For Medical Applicationsmentioning

confidence: 99%

“…They had an anisotropic structure, like the morphology of tissues in the human body like cornea, striated muscles, cartilage, etc., and this is crucial for cell guidance, mass transport, proliferation, and differentiation. [61] A transition metal di-chalcogenide MoSe 2 nanosheet-based nanocomposite hydrogel was used and found to be a dualstimuli responsive material. [62] A polymeric-ionic-liquid functionalized copolymer (poly NIPAM-IL or PNIL using NIPAm and 1-vinylimidazole) effectively exfoliates the MoSe 2 layered nanosheets via the imidazole ring interactions in the PNIL and at the same time, functionalizes the sheets via noncovalent functionalization.…”

Section: Hydrogels For Use In Multifunctional Applicationsmentioning

confidence: 99%

Hydrogels for Medical and Environmental Applications

2020

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Hydrogels are heavily‐hydrated 3D microliths having loose, porous structures. Unlike organogels, elastomers, and carbohydrates, hydrogels are structures with water as a continuous phase/solvent. Being water‐based, they provide a lot of scope for facile improvizations in their structure and in introducing chemical functionalities. They can house various functional materials in their highly porous networks, making them potential candidates for diverse applications. Various possibilities in using different starting materials for hydrogels are described herein, and it is shown how choosing and optimizing these components that make up the hydrogel can modify their properties. Studying hydrogels and their formulations will enable the understanding of their multifunctional properties. External stimuli‐responsive and functional systems can be designed out of these microliths to suit a wide range of applications like biosensing, cancer therapy, regenerative medicine, drug delivery, environmental parameter sensing, water desalination, heavy‐metal adsorption, and water treatment. Environmental degradation is occurring at an alarming rate, cascading the adverse effects on the environment but also causing detrimental effects in public health. In this review, multiple perspectives from state‐of‐the‐art literature are brought together to examine hydrogels as very powerful, sustainable, cost‐effective, and simple solutions for the betterment of the environment and subsequently, public health.

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Injectable Shear-Thinning Fluorescent Hydrogel Formed by Cellulose Nanocrystals and Graphene Quantum Dots

Cited by 102 publications

References 54 publications

3D‐Printed Microfluidic Devices for Materials Science

3D‐Printed Microfluidic Devices for Materials Science

Facile Photo and Thermal Two‐Stage Curing for High‐Performance 3D Printing of Poly(Dimethylsiloxane)

Hydrogels for Medical and Environmental Applications

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