Injectable soft-tissue augmentation by tissue engineering and regenerative medicine with human mesenchymal stromal cells, platelet-rich plasma and hyaluronic acid scaffolds

Evaluation of the benefit of using a combination of autologous platelet rich-plasma and hyaluronic acid for the treatment of Peyronie’s disease

“…Preliminary data seems to indicate that a combination of PRP and HA provides better outcomes than HA alone for the treatment of gonarthrosis [19,20] and wound defects [21,22]. PRP and HA are also expected to increase the potential efficacy of stem cells, as suggested by in vitro and animal studies [13,23]. PRP rich in growth factors and other compounds initiates a reconstructive process in TA, whose global effects are visible through echographic controls.…”

“…From these early experiences, we became interested in an intralesional non-surgical use of PRP for PD. Okabe et al [13] have shown experimentally that the addition of HA to PRP enhanced its regenerative potential, acting as a biological scaffold . The combination of PRP and HA, now facilitated by the availability of the new medical device CellularMatrix, encouraged us to conduct a first trial on 13 patients with PD [14].…”

“…On the other hand, plasma is a source of proteins such as fibrinogen, vitronectin and fibronectin which play a key role in the regulation of cell-cell interaction and cell spatial organization [12]. Autologous PRP has been widely and safely used in many disciplines including orthopaedics, maxillofacial surgery, plastic and reconstructive surgery [13]. Adding thrombin to PRP produces a platelet gel which can be used as biological glue.…”

Aesthetic Regenerative Surgery

“…It is also known that VEGF is released from platelets during blood clotting; hence, combination of fat grafts and PRP may provide a timed release of VEGF in the postoperative period. A positive effect of combining PRP with a natural scaffold and cells has also been recently demonstrated [ 4 ]. On the other hand, although PRP holds promise, more studies are needed to show the real impact of adding PRP to fat grafts [ 3 , 5 ].…”

3D Printed Scaffolds as a New Perspective for Bone Tissue Regeneration: Literature Review

“…That application is possible because the 3D printing technique allows the overcoming of limitations regarding scaffold design and processing posed by conventional techniques [144] [145]. That way, the evolution that bioprinting can bring to the scaffolds field is huge because it makes it possible to have more control over the architecture, allowing the manufacturing of microstructures that mimic the porosity and interconnectivity between the pores in the human body [139].…”