Injectable thermo-sensitive hydrogel containing ADSC-derived exosomes for the treatment of cavernous nerve injury

Liu, Shuai; Li, Ruiyu; Dou, Keke; Li, Kefan; Zhou, Qihui; Fu, Qiang

doi:10.1016/j.carbpol.2022.120226

Cited by 25 publications

(15 citation statements)

References 36 publications

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“…Hydrogel can provide a temporary shelter for cell adhesion, proliferation, and migration, and can also be made into injectable materials with minimum invasiveness, excellent mechanical and functional tunableness. Thermo-sensitive hydrogels which can change phase or swell/deswell as the temperature changes, provide the drug delivery system with optimal spatial and temporal control [ 17 , 96 ]. Therefore, we suggest hydrogels can be a new expectation for ED treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, Liu et al. synthesized a novel injectable thermo-sensitive hydrogel (HG) using hydroxyethyl chitosan (HECTS) and sodium β-glycerophosphate (β-GP) as the main components and used it to encapsulate adipose mesenchymal stem cell-derived exosomes (HG@Exo) [ 17 ]. The designed ADSC-Exo-loaded HG hydrogel enhances the retention of adipose mesenchymal stem cell-derived exosomes and displays a slow release.…”

Section: Current State-of-art Of Hydrogels For Organic Erectile Dysfu...mentioning

confidence: 99%

“…They can be synthesized from various raw materials with different properties, possess a definite composition, and have tunable mechanical properties [ 16 ]. Good biocompatibility and biodegradability also make them an effective drug carrier [ 17 ]. Various drug-loaded hydrogels could promote nerve and vascular regeneration to improve or even reverse the histopathological damage causing ED.…”

Section: Introductionmentioning

confidence: 99%

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Advanced hydrogels: New expectation for the repair of organic erectile dysfunction

Ren

Yuan

Xue

et al. 2023

Materials Today Bio

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Section: Discussionmentioning

confidence: 99%

Section: Current State-of-art Of Hydrogels For Organic Erectile Dysfu...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Advanced hydrogels: New expectation for the repair of organic erectile dysfunction

Ren

Yuan

Xue

et al. 2023

Materials Today Bio

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“…In vivo experiments confirmed that ADSC-derived exosomes loaded within polydopamine thermosensitive hydrogel improved the erectile function by healing the endothelial cells and neurons in penis. On the other side, ADSC-derived exosomes encapsulated into the thermosensitive hydrogel significantly repaired the cavernous nerves injury in rats, thus restoring erectile function ( 57 ).…”

Section: The Therapeutic Potential Of Exosomes In Edmentioning

confidence: 99%

Erectile dysfunction and exosome therapy

Feng

Wei²,

Deng³

et al. 2023

Front. Endocrinol.

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Erectile dysfunction (ED), as a common male disease, can seriously reduce the life quality of men and their partners. With the improvement of human living standards, ED is considered to be an important health issue that plagues men. However, it is difficult for existing therapeutic approaches to meet the needs of all patients, so it is necessary to develop novel treatment strategies. Exosomes, as a class of vesicles secreted by cells with bilayer membrane structure, are involved in various physiological and pathological processes in human body and considered to have great therapeutic potentials. This review summarizes the recent advances on exosome therapy with animal models of ED, and proposes the prospect of future research in order to provide a basis for clinical trials and clinical translation.

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“…Various kinds of hydrogels have been used to protect Exos and enhance the therapeutic effects of Exos. [30][31][32][33] Among these hydrogel materials, poly(ethylene glycol) (PEG) has been extensively used for the fabrication of biocompatible hydrogels for tissue engineering and cartilage repair. [34,35] Hyaluronic acid (HA) is one of the most versatile and fascinating macromolecules in the natural world and is one of the most widely used medical treatments for OA.…”

Section: Introductionmentioning

confidence: 99%

Sustained released of microRNA-99b-3p abundant exosomes derived from adipose stem cell encapsulated with hydrogel microparticles (HMPs) for long-term osteoarthritis treatment

Yin¹,

Pan

Shi

et al. 2023

Preprint

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Adipose derived stem cells (ADSCs) have the potential to attenuate osteoarthritis (OA); however, complications such as immune rejection and tumour formation limit their application. Exosomes (Exos)-mediated acellular therapy is promising in alleviating OA. This study aims to confirm whether ADSC-exos derived from infrapatellar fat pad (IPFP, ExosIPFP) are more suitable for ameliorating OA than ADSC-exos derived from subcutaneous fat (ScAT, ExoScAT) in vitro and in DMM models. Then, we investigated the regulatory mechanism by which the two kinds of Exos inhibit extracellular matrix (ECM) degradation in OA. ADSCs were successfully isolated and Exos were then obtained. ExosIPFP exhibited better attenuated effects on osteoarthritic chondrocytes in vitro and in vivo than ExoScAT. Small RNA sequencing was performed and the results shown that miR-99b-3p was upregulated in ExosIPFP. In vitro experiments confirmed that ADAMTS4 is a direct downstream target of miR-99b-3p. Over-expression miR-99b-3p in ExosScAT (ExosScAT-99b-3p) indicated that miR-99b-3p serves a positive role for OA treatment by inhibiting ADAMTS4 expression both in vitro and in vivo. In addition, hydrogel microparticles (HMPs) system was prepared by microfluidic technology, and confirmed the beneficial results for long-term therapeutic by continuous release of Exos. Take together, these results suggest that the therapeutic effects of ADSC-Exos may vary according to differential expression of miRNAs. Exosomal miR-99b-3p may act as a promising therapeutic strategy for OA, in addition, the injectable HMPs act as a sustained local drug release system, therefore representing great potential for treating OA and other diseases.

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Injectable thermo-sensitive hydrogel containing ADSC-derived exosomes for the treatment of cavernous nerve injury

Cited by 25 publications

References 36 publications

Advanced hydrogels: New expectation for the repair of organic erectile dysfunction

Advanced hydrogels: New expectation for the repair of organic erectile dysfunction

Erectile dysfunction and exosome therapy

Sustained released of microRNA-99b-3p abundant exosomes derived from adipose stem cell encapsulated with hydrogel microparticles (HMPs) for long-term osteoarthritis treatment

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