Injectable thermo-sensitive hydrogel enhances anti-tumor potency of engineered Lactococcus lactis by activating dendritic cells and effective memory T cells

Chen, Aoxing; Zhu, Junmeng; Liu, Rui; Mei, Yi; Li, Lin; Fan, Yue; Ke, Yaohua; Liu, Baorui; Liu, Qin

doi:10.1016/j.bioactmat.2024.03.023

Bioactive Materials

2024

DOI: 10.1016/j.bioactmat.2024.03.023

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Injectable thermo-sensitive hydrogel enhances anti-tumor potency of engineered Lactococcus lactis by activating dendritic cells and effective memory T cells

Aoxing Chen,

Junmeng Zhu,

Rui Liu

et al.

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2024

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Cited by 3 publications

References 55 publications

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An Immune‐Enhancing Injectable Hydrogel Loaded with Esketamine and DDP Promotes Painless Immunochemotherapy to Inhibit Breast Cancer Growth

Yin,

Ke,

Liang

et al. 2024

Adv Healthcare Materials

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Chemotherapy is the cornerstone of triple‐negative breast cancer. The poor effectiveness and severe neuropathic pain caused by it have a significant impact on the immune system. Studies confirmed that immune cells in the tumor microenvironment (TME), have critical roles in tumor immune regulation and prognosis. In this study, it is revealed that the painless administration of Esketamine, combined with Cisplatin (DDP), can exert an anti‐tumor effect, which is further boosted by the hydrogel delivery system. It is also discovered that Esketamine combined with DDP co‐loaded in Poloxamer Hydrogel (PDEH) induces local immunity by increasing mature Dendritic Cells (mDCs) and activated T cells in PDEH group while the regulatory T cells (Tregs) known as CD4+CD25+FoxP3+decreased significantly. Finally, , CD8+ and CD4+ T cells in the spleen exhibited a significant increase, suggesting a lasting immune impact of PDEH. This study proposes that Esketamine can serve as a painless immune modulator, enhancing an anti‐tumor effect while co‐loaded in poloxamer hydrogel with DDP. Along with improving immune cells in the microenvironment, it can potentially alleviate anxiety and depression. With its outstanding bio‐safety profile, it offers promising new possibilities for painless clinical therapy.

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An Immune‐Enhancing Injectable Hydrogel Loaded with Esketamine and DDP Promotes Painless Immunochemotherapy to Inhibit Breast Cancer Growth

Yin,

Ke,

Liang

et al. 2024

Adv Healthcare Materials

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Targeting CDK1 and copper homeostasis in breast cancer via a nanopolymer drug delivery system

Shang,

Zhu,

et al. 2024

Cell Biol Toxicol

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Phenylboronic Acid-Functionalized Injectable Polypeptide Hydrogels with Responsive Drug Release

Wang,

Yin,

Guo

et al. 2024

ACS Appl. Polym. Mater.

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Phenylboronic acid-functionalized materials have shown great potential for versatile biomedical applications. Here, we report a facile strategy to construct phenylboronic acidfunctionalized copolypeptides (mPEG-b-P(BCys-co-MGlu)) by ring-opening polymerization of S-(4-boronic acid benzyl)-Lcysteine N-carboxyanhydride (BCys NCA) and γ-methyl-Lglutamate N-carboxyanhydride (MGlu NCA) monomers. The S-(4-boronic acid benzyl)-L-cysteine (BCys) residues contain pendant phenylboronic acid groups, not only providing robust drug encapsulation capacity by virtue of N−B coordination, hydrophobic interaction, and π−π stacking but also exhibiting stimulus (GSH, H 2 O 2 , and pH)-triggered drug release. The sol-togel critical transition temperature and in vivo degradation could be tailored by adjusting the compositions of copolypeptides. The copolymer mPEG-b-P(BCys 3 -co-MGlu 10 ) enables a sol-to-gel transition in the range of 5.6−30.3 °C at different concentrations. The prepared injectable phenylboronic acid-functionalized polypeptide hydrogel with responsive release behaviors shows great potential for local delivery applications.

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Injectable thermo-sensitive hydrogel enhances anti-tumor potency of engineered Lactococcus lactis by activating dendritic cells and effective memory T cells

Cited by 3 publications

References 55 publications

An Immune‐Enhancing Injectable Hydrogel Loaded with Esketamine and DDP Promotes Painless Immunochemotherapy to Inhibit Breast Cancer Growth

An Immune‐Enhancing Injectable Hydrogel Loaded with Esketamine and DDP Promotes Painless Immunochemotherapy to Inhibit Breast Cancer Growth

Targeting CDK1 and copper homeostasis in breast cancer via a nanopolymer drug delivery system

Phenylboronic Acid-Functionalized Injectable Polypeptide Hydrogels with Responsive Drug Release

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