Injection-Molded Capsular Device for Oral Pulsatile Release: Development of a Novel Mold

Zema, L.; Loreti, G.; Macchi, E.; Foppoli, Anastasia; Maroni, Alessandra; Gazzaniga, A.

doi:10.1002/jps.23371

Cited by 34 publications

(32 citation statements)

References 26 publications

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“…Chronocap™ capsule shells (600 mm) were prepared by IM starting from a mixture of HPC with 10% w/w of a plasticizer (PEG) [12]. In order to undertake the manufacturing of analogous devices by FDM, HPC-based filaments were needed.…”

Section: Preparation and Characterization Of Hpc Capsular Devicesmentioning

confidence: 99%

“…2). A PLA raft was only designed to connect the building platform with the void object, thus keeping it With the aim of attaining capsule shells with design characteristics fully corresponding to those of the Chronocap™ device previously prepared by IM, the mold used for the manufacturing of a 600 mm thick system was referred to [12]. Suitable technical drawings of the capsule parts and subsequently the relevant CAD files were built prior to printing (Fig.…”

Section: Feasibility Of Fdm In the Manufacturing Of Capsular Devicesmentioning

confidence: 99%

“…molded and printed capsular devices based on HPC, filled with approximately 80 mg of blue-dye containing formulation, were immersed in unstirred deionized water at the temperature of 37 ± 0.5 C, and digital photographs were taken at successive time points (Nikon D70, Nikon, J) [12].…”

Section: 242mentioning

confidence: 99%

See 2 more Smart Citations

3D printing by fused deposition modeling (FDM) of a swellable/erodible capsular device for oral pulsatile release of drugs

Melocchi

Parietti

Loreti

et al. 2015

Journal of Drug Delivery Science and Technology

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261

153

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Section: Preparation and Characterization Of Hpc Capsular Devicesmentioning

confidence: 99%

Section: Feasibility Of Fdm In the Manufacturing Of Capsular Devicesmentioning

confidence: 99%

See 1 more Smart Citation

3D printing by fused deposition modeling (FDM) of a swellable/erodible capsular device for oral pulsatile release of drugs

Melocchi

Parietti

Loreti

et al. 2015

Journal of Drug Delivery Science and Technology

Self Cite

261

153

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“…As a preliminary step, hot-plate and air shot tests were performed to determine or confirm the working temperatures of the selected polymers and assess whether plasticizers were needed DOI 10.1002/jps.24419 or not. 39,40 The choice of the type and amount of plasticizer as well as the identification of parameters to be used for the evaluation of HME and IM processability, were then accomplished through the preparation of extruded sheets (1 mm in thickness) and molded disk-shaped prototypes (1 mm in thickness and 30 mm in diameter), respectively ( Table 1). The HME processability of materials under investigation was evaluated based on morphological (uniformity of shape and thickness) and mechanical characteristics of extruded sheets.…”

Section: Screening Of Tablet-forming Agentsmentioning

confidence: 99%

Evaluation of Hot-Melt Extrusion and Injection Molding for Continuous Manufacturing of Immediate-Release Tablets

Melocchi

Loreti

Curto

et al. 2015

Journal of Pharmaceutical Sciences

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The exploitation of hot-melt extrusion and injection molding for the manufacturing of immediate-release (IR) tablets was preliminarily investigated in view of their special suitability for continuous manufacturing, which represents a current goal of pharmaceutical production because of its possible advantages in terms of improved sustainability. Tablet-forming agents were initially screened based on processability by single-screw extruder and micromolding machine as well as disintegration/dissolution behavior of extruded/molded prototypes. Various polymers, such as low-viscosity hydroxypropylcellulose, polyvinyl alcohol, polyvinyl alcohol-polyethylene glycol graft copolymer, various sodium starch glycolate grades (e.g., Explotab(®) CLV) that could be processed with no need for technological aids, except for a plasticizer, were identified. Furthermore, the feasibility of both extruded and molded IR tablets from low-viscosity hydroxypropylcellulose or Explotab(®) CLV was assessed. Explotab(®) CLV, in particular, showed thermoplastic properties and a very good aptitude as a tablet-forming agent, starting from which disintegrating tablets were successfully obtained by either techniques. Prototypes containing a poorly soluble model drug (furosemide), based on both a simple formulation (Explotab(®) CLV and water/glycerol as plasticizers) and formulations including dissolution/disintegration adjuvants (soluble and effervescent excipients) were shown to fulfill the USP 37 dissolution requirements for furosemide tablets.

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“…More recently, time-dependent reservoir systems in the form of capsules were proposed [32][33][34]. Particularly, HPC was the first thermoplastic cellulosic derivative employed for the fabrication of capsule caps and bodies via injection molding (IM) to convey drug-containing preparations [35,36]. The capsules registered under the name of Chronocap™ showed the ability to release their contents after a predetermined lag phase, tunable according to the molecular weight of the selected HPC and the thickness of the molded shell.…”

Section: Introductionmentioning

confidence: 99%

Injection Molded Capsules for Colon Delivery Combining Time-Controlled and Enzyme-Triggered Approaches

Casati

Melocchi

Moutaharrik

et al. 2020

IJMS

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A new type of colon targeting system is presented, combining time-controlled and enzyme-triggered approaches. Empty capsule shells were prepared by injection molding of blends of a high-amylose starch and hydroxypropyl methylcellulose (HPMC) of different chain lengths. The dissolution/erosion of the HPMC network assures a time-controlled drug release, i.e., drug release starts upon sufficient shell swelling/dissolution/erosion. In addition, the presence of high-amylose starch ensures enzyme-triggered drug release. Once the colon is reached, the local highly concentrated bacterial enzymes effectively degrade this polysaccharide, resulting in accelerated drug release. Importantly, the concentration of bacterial enzymes is much lower in the upper gastrointestinal tract, thus enabling site-specific drug delivery. The proposed capsules were filled with acetaminophen and exposed to several aqueous media, simulating the contents of the gastrointestinal tract using different experimental setups. Importantly, drug release was pulsatile and occurred much faster in the presence of fecal samples from patients. The respective lag times were reduced and the release rates increased once the drug started to be released. It can be expected that variations in the device design (e.g., polymer blend ratio, capsule shell geometry and thickness) allow for a large variety of possible colon targeting release profiles.

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Injection-Molded Capsular Device for Oral Pulsatile Release: Development of a Novel Mold

Cited by 34 publications

References 26 publications

3D printing by fused deposition modeling (FDM) of a swellable/erodible capsular device for oral pulsatile release of drugs

3D printing by fused deposition modeling (FDM) of a swellable/erodible capsular device for oral pulsatile release of drugs

Evaluation of Hot-Melt Extrusion and Injection Molding for Continuous Manufacturing of Immediate-Release Tablets

Injection Molded Capsules for Colon Delivery Combining Time-Controlled and Enzyme-Triggered Approaches

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