2003
DOI: 10.1097/00006982-200306000-00048
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Injection of Tissue Plasminogen Activator into a Branch Retinal Vein in Eyes with Central Retinal Vein Occlusion.

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Cited by 47 publications
(70 citation statements)
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“…Bynoe Bynoe also disputes the assertion that there is no other effective treatment citing results from studies utilising external approaches to decompress the optic nerve 59,60,58 and tissue plasminogen activator, [53][54][55] some of which showed similar results, although he acknowledges their complications. Hayreh 67 challenges the claims made by Opremcak on several counts.…”
Section: Radial Optic Neurotomy For Central Retinal Vein Occlusionmentioning
confidence: 99%
“…Bynoe Bynoe also disputes the assertion that there is no other effective treatment citing results from studies utilising external approaches to decompress the optic nerve 59,60,58 and tissue plasminogen activator, [53][54][55] some of which showed similar results, although he acknowledges their complications. Hayreh 67 challenges the claims made by Opremcak on several counts.…”
Section: Radial Optic Neurotomy For Central Retinal Vein Occlusionmentioning
confidence: 99%
“…The Central Vein Occlusion Study showed that the grid pattern photocoagulation definitely reduced macular oedema on fluorescein angiography but failed to show statistically significant visual acuity benefit. 4 Recent reports have suggested other treatment modalities investigated in case series, including laser-induced chorioretinal venous anastomosis, 5 intravitreal tissue plasminogen activator, 6,7 surgical induction of chorioretinal venous anastomosis, 8 and radial optic neurotomy, 9 to improve the circulatory status of the retina after CRVO. However, these studies, although encouraging, are still controversial and have not yet been sufficiently supported by larger randomised clinical trials.…”
Section: Introductionmentioning
confidence: 99%
“…In addition, intravitreal injection of t-PA had some complications such as vitreous haemorrhage and increase in macular edema. Because of these unsuccessful results, different ways were searched to administration of t-PA into the obstructed retinal vein and in the year of 2001 Weiss and Bynoe described a surgical procedure that allowed direct injection of t-PA into the obstructed vein [20] . This surgical procedure included PPV with peeling of posterior hyaloid followed by cannulation of a peripapillary retinal vein branch and injection of a bolus 200µg/mL t-PA towards the optic nerve head (ONH).…”
Section: Introductionmentioning
confidence: 99%