Injection-Site Cutaneous Pseudolymphoma Induced by a GM-CSF–Producing Tumor Cell Vaccine

Staser, Karl; Abner, Sabra M.; Anadkat, Milan J.; Musiek, Amy; Schaffer, András

doi:10.1001/jamadermatol.2016.4988

Cited by 6 publications

(7 citation statements)

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“…While the exact pathogenesis of the disease remains unclear, recent studies suggest that drugs responsible for causing CPL can weaken immune function by interfering with immunosurveillance leading to abnormal lymphocyte proliferation, increased suppressor T-cell activity and hypogammaglobulinaemia. [8][9][10][11][12][13][14] Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is now considered different from drug-induced CPL. Some features of DRESS syndrome are fever, haematological abnormalities (eosinophilia), systemic symptoms, lymphadenopathy and morbilliform eruption.…”

Section: Introductionmentioning

confidence: 99%

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Drug‐induced cutaneous pseudolymphoma: A systematic review of the literature

et al. 2022

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Drug‐induced cutaneous pseudolymphoma (CPL) is a common form of pseudolymphoma and there are numerous drugs associated with it. In this study, we performed a systematic review of the literature by searching PubMed/Medline and Embase databases to determine the most common drugs responsible for CPL and to define the demographic, clinical, histopathological and immunopathological characteristics of patients (updated on 30 December 2020). From 883 initially found articles, 56 studies (89 reported cases) were included. The mean age of patients was 54.4 ± 17.7 (ranging 8–86) years, and 46 (51.7%) were men. The median time interval between drug intake and CPL occurrence was 120 days (range 1–7300 days). The shortest median time interval between taking the drug and the onset of the disease was observed among patients taking antidepressants (60 days) (range 7–540) and the longest median time interval was observed in individuals using immunomodulators (300 days) (range 3–7300). The most‐reported drug categories causing CPL were anti‐hypertensives (17.9%), anticonvulsants (14.6%), monoclonal antibodies (13.4%) and antidepressants (11.2%). Moreover, the most common drugs were phenytoin (6.7%), amlodipine (5.6%), fluoxetine (5.6%) and carbamazepine (4.4%). Histopathological evaluation of 76 cases revealed 62 (81.5%) reports of T‐cell infiltrations. Furthermore, positive reports of CD4 (94.0%), CD8 (93.0%) and CD30 (87.5%) were noted. The lowest prevalence of CD30‐positive reports was observed among monoclonal antibodies. In conclusion, anti‐hypertensives, anti‐convulsants, monoclonal antibodies and anti‐depressants are the most common drugs responsible for CPL. It mostly presents in middle‐aged patients with almost no gender difference as pruritic papules, nodules and plaques.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Drug‐induced cutaneous pseudolymphoma: A systematic review of the literature

et al. 2022

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“…Das CPL wurde im Zusammenhang mit allen oben genannten Impfstoffen beschrieben -dieser Bericht ist unseres Wissens nach jedoch der erste über ein CPL nach einer Vierfach-HPV-Impfung. Es gab einen zeitlichen Zusammenhang zwischen der Impfung und den Symptomen, obwohl das Intervall außergewöhnlich lang war [ [5]. Inzwischen hält diese Erkenntnis immer mehr Einzug in Patientenforen [6], aber auch unter Laserdermatologen [7].…”

Section: Clinical Letterunclassified

Kutanes Pseudolymphom nach quadrivalenter HPV‐Impfung – eine seltene Nebenwirkung

Pinheiro

Duarte

João

et al. 2018

J Deutsche Derma Gesell

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“…In most cases, aluminum hydroxide was present as an adjuvant [3,4,6], for which it has been suggested that it could have a causal role. However, there are cases in which this adjuvant was not present [7] Most CPL developed at the injection site of the vaccines tend to have a benign course, but, very rarely, they have evolved to lymphomas [8,9]; the causes were flu and anthrax vaccines and one of the patients had a fatal outcome [8].…”

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confidence: 99%