Injury produced by free fatty acids to lysosomes and mitochondria in cultured heart muscle and endothelial cells

Acosta, Daniel; Wenzel, Duane G.

doi:10.1016/0021-9150(74)90023-9

Cited by 62 publications

(23 citation statements)

References 26 publications

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“…Free fatty acids per se are potentially cytotoxic, causing mitochondrial swelling, increased liposomal fragility, depression of enzyme activity, and impairment of membrane integrity. 15 Furthermore, the accumulation of abnormally high amounts of lipid peroxidation products increases stellate cell activation and collagen synthesis with the consequent progression to cirrhosis and end-stage liver disease. 14 However, the association of lipid peroxidation and hepatic fibrosis is not exclusive of NASH and it seems to be present in other liver damage such as alcohol-induced liver disease.…”

Section: Discussionmentioning

confidence: 99%

Risk factors of fibrosis in alcohol-induced liver disease

et al. 2002

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In patients with nonalcoholic steatohepatitis (NASH), age, obesity, and diabetes mellitus are independent predictors of the degree of fibrosis. The relative risk for fibrosis adjusted for sex was also associated with increasing grade of Perls stain. The aim of this study was to determine whether the risk factors for fibrosis described in NASH are also risk factors in alcohol-induced liver disease. A total of 268 alcoholic patients with negative hepatitis B virus and hepatitis C virus serology underwent liver biopsy. Fibrosis was assessed semiquantitatively by a score fluctuating between 0 to 8. Liver iron overload was assessed by Perls staining and graded in 4 classes. We have used multivariate regression with partial correlation analysis to assess the variability of fibrosis score according to the value of 7 variables: sex, age, body mass index (BMI) in the past year before the hospitalization when the patient was asymptomatic, daily alcohol intake over the past 5 years, total duration of alcohol abuse, Perls grade, and blood glucose level. In the multivariate regression, fibrosis score was positively correlated with age (P ‫؍‬ .001), BMI (P ‫؍‬ .002), female sex (P < .05), Perls grade (P < .05), and blood glucose level (P < .05). Twenty percent of the variability of fibrosis score was explained by the 7 variables. In conclusion, after adjustment for daily alcohol intake and total duration of alcohol abuse, BMI, Perls grade, and blood glucose are also independent risk factors for fibrosis in alcohol-induced liver disease, raising therapeutic implications for the management of these patients. (HEPATOLOGY 2002;35:635-638.)

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Section: Discussionmentioning

confidence: 99%

Risk factors of fibrosis in alcohol-induced liver disease

et al. 2002

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“…Free fatty acids per se are potentially cytotoxic causing mitochondrial swelling, increased lysosomal fragility, depression of enzyme activity, and impairment of membrane integrity. 39 This cellular damage with subsequent inflammation may result in cellular death and fibrosis. Levels of circulating free fatty acids and the rate of presentation to the liver may contribute to development of more severe liver disease in NASH patients who also suffer from diabetes.…”

Section: Discussionmentioning

confidence: 99%

Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis

et al. 1999

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Nonalcoholic steatohepatitis (NASH) may present with increased hepatic fibrosis progressing to end‐stage liver disease. No factors that determine increasing fibrosis and histologically advanced disease have been recognized, thus, liver biopsy is recommended in all patients for diagnosis and prognosis. Our aim was to identify independent predictors of severe hepatic fibrosis in patients with NASH. One hundred and forty‐four patients were studied. All patients underwent liver biopsy. Clinical and biochemical variables were examined with univariate and multivariate analysis. Thirty‐seven (26%) patients had no abnormal fibrosis, 53 (37%) had mild fibrosis, 15 (10%) had moderate fibrosis, 14 (10%) had bridging fibrosis, and 25 (17%) had cirrhosis. In multivariate analysis, older age (P = .001), obesity (P = .002), diabetes mellitus (P = .009), and aspartate transaminase/alanine transaminase (AST/ALT) ratio greater than 1 (P = .03) were significant predictors of severe liver fibrosis (bridging/cirrhosis). Body mass index (P = .003) was the only independent predictor of the degree of fat infiltration. Increased transferrin saturation correlated positively with the severity of fibrosis (P = .02) in univariate analysis, and there was a trend for more female patients among those with more advanced fibrosis (P = .09). However, iron studies or gender were not significant when controlled for age, obesity, diabetes, and AST/ALT ratio. In conclusion, older age, obesity, and presence of diabetes mellitus help identify those NASH patients who might have severe liver fibrosis. This is the subgroup of patients with NASH who would be expected to derive the most benefit from having a liver biopsy and considering investigational therapies.

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“…7 Free fatty acids (especially the unsaturated variety) can in turn impair hepatocytic membrane integrity, depress enzyme activity, directly injure blood vessels, cause mitochondrial swelling, and increase lysosomal fragility. 8 These actions can initiate and perpetuate an inflammatory reaction that can result in fibrosis and cirrhosis.…”

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confidence: 99%

Recurrence of nonalcoholic steatohepatitis after liver transplantation

Czaja¹

1997

Liver Transpl

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Injury produced by free fatty acids to lysosomes and mitochondria in cultured heart muscle and endothelial cells

Cited by 62 publications

References 26 publications

Risk factors of fibrosis in alcohol-induced liver disease

Risk factors of fibrosis in alcohol-induced liver disease

Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis

Recurrence of nonalcoholic steatohepatitis after liver transplantation

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