Inkjet-printed flexible non-enzymatic lactate sensor with high sensitivity and low interference using a stacked NiOx/NiOx-Nafion nanocomposite electrode with clinical blood test verification

Tsou, Kun-Lin; Chen, Kuan-Yun; Chou, Yueh-Ching; Cheng, Yu-Ting; Tsai, Hsiao‐En; Lee, Chih‐Kuo

doi:10.1016/j.talanta.2022.123598

Cited by 11 publications

(1 citation statement)

References 36 publications

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“… 25 LOx/PdCu/LIG 0.1–30 mM 51.91 – Tsou et al. 26 LOx/NiOx-Nafion 0.5–4 mM 205.6 270 Neampet et al. 27 LOx/Pt/PANI/MXene 0.005–5.0 mM 5.64 5 Heikenfeld et al.…”

Section: Resultsmentioning

confidence: 99%

Continuous monitoring of multiple biomarkers with an ultrasensitive 3D-structured wearable biosensor

Yang,

Wang,

Cheng

2023

Cell Reports Methods

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“… 25 LOx/PdCu/LIG 0.1–30 mM 51.91 – Tsou et al. 26 LOx/NiOx-Nafion 0.5–4 mM 205.6 270 Neampet et al. 27 LOx/Pt/PANI/MXene 0.005–5.0 mM 5.64 5 Heikenfeld et al.…”

Section: Resultsmentioning

confidence: 99%

Continuous monitoring of multiple biomarkers with an ultrasensitive 3D-structured wearable biosensor

Yang,

Wang,

Cheng

2023

Cell Reports Methods

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Real‐Time Lactate Detection in A Dynamic Environment Using Micrsensing Needles

Tang,

Huang,

Yang

et al. 2024

Advanced Sensor Research

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This study introduces a novel microneedle‐based lactate sensor with SU‐8 micropillar enhancement, designed for real‐time monitoring in dynamic environments. Utilizing inkjet‐printing technology, the sensor demonstrates enhanced sensitivity and a reduced limit of detection (LoD), addressing critical challenges in clinical applications like hemodialysis and patient monitoring in ICU. Design enhancements in the medical steel needle improve stress resistance during insertion, contributing to the sensor's reliability. The experimental findings demonstrate that the microneedle is capable of achieving a high level of linearity at 0.99, with a sensitivity of 3.38 µA mM−1/mm−2–0.5 µA mM−1/mm−2 observed within the range of 0.1–0.5 mM and 1–10 mM, respectively. Meanwhile, the microneedle exhibits a low limit of detection (LoD) of 0.01 mM when tested in phosphate‐buffered saline (PBS) with varying lactate concentrations. Moreover, it demonstrates a linearity of 0.98, sensitivity of 1.13 µA mM−1 mm−2, and the same LoD of 0.01 mM in urine. The sensor maintains its performance at flow rates up to 500 mL min−1. Overall, this flexible and inkjet‐printed lactate sensor represents a significant advancement in real‐time clinical monitoring technology.

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Inkjet Printed Multifunctional Graphene Sensors for Flexible and Wearable Electronics

Wang,

Heaton,

Cottam

et al. 2024

Adv Elect Materials

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The exceptional electrical properties of graphene with high sensitivity to external stimuli make it an ideal candidate for advanced sensing technologies. Inkjet printing of graphene (iGr) can provide a versatile platform for multifunctional sensor manufacturing. Here the multifunctional sensor enabled by combining the design freedom of inkjet printing with the unique properties of graphene networks is reported on. A fully inkjet printed multimaterial device consists of two layers of iGr stripes separated by a dielectric polymeric layer of tripropylene glycol diacrylate (TPGDA). In these devices, the bottom iGr layer, capped with TPGDA, provides temperature sensing, the top uncapped iGr is sensitive to the external atmosphere, while the capacitance between the two iGr layers is sensitive to the applied pressure. The fast, sensitive, and reproducible performance of these sensors are demonstrated in response to environmental stimuli, such as pressure, temperature, humidity, and magnetic field. The devices are capable of simultaneous sensing of multiple factors and are successfully manufactured on a variety of substrates, including Si/SiO2, flexible Kapton films and textiles, demonstrating their potential impact in applications compatible with silicon technologies as well as wearable and healthcare devices.

show abstract

Inkjet-printed flexible non-enzymatic lactate sensor with high sensitivity and low interference using a stacked NiOx/NiOx-Nafion nanocomposite electrode with clinical blood test verification

Cited by 11 publications

References 36 publications

Continuous monitoring of multiple biomarkers with an ultrasensitive 3D-structured wearable biosensor

Continuous monitoring of multiple biomarkers with an ultrasensitive 3D-structured wearable biosensor

Real‐Time Lactate Detection in A Dynamic Environment Using Micrsensing Needles

Inkjet Printed Multifunctional Graphene Sensors for Flexible and Wearable Electronics

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