Inkjet-printed morphogenesis of tumor-stroma interface using bi-cellular bioinks of collagen-poly(N-isopropyl acrylamide-co-methyl methacrylate) mixture

Cheng, Cih; Deneke, Naomi; Moon, Hye-ran; Choi, Sae Rome; Ospina-Muñoz, Natalia; Elzey, Bennett D.; Davis, Chelsea S.; Chiu, George T.‐C.; Han, Bumsoo

doi:10.1016/j.mtadv.2023.100408

Cited by 3 publications

(2 citation statements)

References 69 publications

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“…By precisely controlling the spatial distribution of cancer cells and surrounding stroma within hydrogels, inkjet printing enables the creation of more accurate and reproducible tumor models compared to traditional two-dimensional cultures [ 63 ]. Additionally, a study has developed a new method to rapidly create tumor models with tumor-stroma interface at extremely high cell density, so-called tumoroid, by inkjet printing of multi-line bioinks [ 67 ]. The mechanism of the method is that cellular contractile force can significantly remodel the cell-laden polymer matrix to form densely packed tissue-like constructs, as illustrated in Fig.…”

Section: Emerging Biomedical Advancesmentioning

confidence: 99%

“…Modified from [ 66 ] with permission from Nature Portfolio ( B ) Schematic of inkjet printing of cell-laden interpenetrating-polymer inks along with the hypothesized mechanism of tissue compaction and the corresponding 0–24 h time-lapse images showing the active shrinking of printed structure (green: CAF, red: Pacn10.05, scale bar: 500um). Reprinted from [ 67 ] under a Creative Commons license …”

Section: Emerging Biomedical Advancesmentioning

confidence: 99%

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Engineering biomaterials by inkjet printing of hydrogels with functional particulates

Cheng,

Williamson,

Chiu

et al. 2024

Med-X

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Hydrogels with particulates, including proteins, drugs, nanoparticles, and cells, enable the development of new and innovative biomaterials. Precise control of the spatial distribution of these particulates is crucial to produce advanced biomaterials. Thus, there is a high demand for manufacturing methods for particle-laden hydrogels. In this context, 3D printing of hydrogels is emerging as a promising method to create numerous innovative biomaterials. Among the 3D printing methods, inkjet printing, so-called drop-on-demand (DOD) printing, stands out for its ability to construct biomaterials with superior spatial resolutions. However, its printing processes are still designed by trial and error due to a limited understanding of the ink behavior during the printing processes. This review discusses the current understanding of transport processes and hydrogel behaviors during inkjet printing for particulate-laden hydrogels. Specifically, we review the transport processes of water and particulates within hydrogel during ink formulation, jetting, and curing. Additionally, we examine current inkjet printing applications in fabricating engineered tissues, drug delivery devices, and advanced bioelectronics components. Finally, the challenges and opportunities for next-generation inkjet printing are also discussed. Graphical Abstract

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Section: Emerging Biomedical Advancesmentioning

confidence: 99%

Section: Emerging Biomedical Advancesmentioning

confidence: 99%

Engineering biomaterials by inkjet printing of hydrogels with functional particulates

Cheng,

Williamson,

Chiu

et al. 2024

Med-X

View full text Add to dashboard Cite

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On‐Demand Picoliter‐Level‐Droplet Inkjet Printing for Micro Fabrication and Functional Applications

You,

Wang,

Lin

et al. 2024

Small

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With the advent of Internet of Things (IoTs) and wearable devices, manufacturing requirements have shifted toward miniaturization, flexibility, environmentalization, and customization. Inkjet printing, as a non‐contact picoliter‐level droplet printing technology, can achieve material deposition at the microscopic level, helping to achieve high resolution and high precision patterned design. Meanwhile, inkjet printing has the advantages of simple process, high printing efficiency, mask‐free digital printing, and direct pattern deposition, and is gradually emerging as a promising technology to meet such new requirements. However, there is a long way to go in constructing functional materials and emerging devices due to the uncommercialized ink materials, complicated film‐forming process, and geometrically/functionally mismatched interface, limiting film quality and device applications. Herein, recent developments in working mechanisms, functional ink systems, droplet ejection and flight process, droplet drying process, as well as emerging multifunctional and intelligence applications including optics, electronics, sensors, and energy storage and conversion devices is reviewed. Finally, it is also highlight some of the critical challenges and research opportunities. The review is anticipated to provide a systematic comprehension and valuable insights for inkjet printing, thereby facilitating the advancement of their emerging applications.

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Recent advances of collagen composite biomaterials for biomedical engineering: antibacterial functionalization and 3D-printed architecturalization

Zheng,

Tseomashko,

Voronova

et al. 2024

Collagen & Leather

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Collagen possesses high biocompatibility with all tissue and cell types in the body, enabling the creation of multifunctional composite materials for medical applications. In biomedical engineering, naturally-sourced collagen is often combined with diverse organic and inorganic bioactive components to eliminate defects and disorders in fields including orthopedics, dermatology, and more. At the same time, medical-related infection issues and the precise treatment needs of patients require collagen composite biomaterials to have antibacterial properties and customized structures. This paper reviews the antibacterial functionalization of collagen composite biomaterials in recent years, including the combination with inorganic or organic antibacterial agents, which is beneficial for preventing and controlling biological contamination in medical applications. Then, the existing problems and future development directions for the architecturalization of collagen composite materials with 3D printing were discussed, providing guidance for personalized customization of multifunctional materials to meet the specific needs of patients in the future. Graphical Abstract

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Inkjet-printed morphogenesis of tumor-stroma interface using bi-cellular bioinks of collagen-poly(N-isopropyl acrylamide-co-methyl methacrylate) mixture

Cited by 3 publications

References 69 publications

Engineering biomaterials by inkjet printing of hydrogels with functional particulates

Engineering biomaterials by inkjet printing of hydrogels with functional particulates

On‐Demand Picoliter‐Level‐Droplet Inkjet Printing for Micro Fabrication and Functional Applications

Recent advances of collagen composite biomaterials for biomedical engineering: antibacterial functionalization and 3D-printed architecturalization

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