Inkjet Printing of Pharmaceuticals

Abstract

Inkjet printing (IJP) is an additive manufacturing process that selectively deposits ink materials, layer‐by‐layer, to create three‐dimensional (3D) objects or two‐dimensional (2D) patterns with precise control over their structure and composition. This technology has emerged as an attractive and versatile approach to address the ever‐evolving demands of personalized medicine in the healthcare industry. Although originally developed for non‐healthcare applications, IJP harnesses the potential of pharma‐inks, which are meticulously formulated inks containing drugs and pharmaceutical excipients. Delving into the formulation and components of pharma‐inks, the key to precise and adaptable material deposition enabled by IJP is unraveled. The review extends its focus to substrate materials, including paper, films, foams, lenses, and 3D‐printed materials, showcasing their diverse advantages, whilst exploring a wide spectrum of therapeutic applications. Additionally, the potential benefits of hardware and software improvements, along with artificial intelligence integration, are discussed to enhance IJP's precision and efficiency. Embracing these advancements, IJP holds immense potential to reshape traditional medicine manufacturing processes, ushering in the era of medical precision. However, further exploration and optimization are needed to fully utilize IJP's healthcare capabilities. As researchers push the boundaries of IJP, the vision of patient‐specific treatment is on the horizon of becoming a tangible reality.This article is protected by copyright. All rights reserved

3D Printing of Dietary Products for the Management of Inborn Errors of Intermediary Metabolism in Pediatric Populations

“…In recent years, 3D printing technologies have garnered substantial attention across various industries [ 81 , 82 ], including medicine, owing to their capacity to create 3D objects layer-by-layer from digital models [ 83 ]. Particularly within the pharmaceutical realm, 3D printing offers unique opportunities to fabricate customized pharmaceutical products [ 84 , 85 ], providing full design customization, flexibility, and high control over drug release, dose personalization, and the capacity to print multiple drugs [ 86 , 87 , 88 , 89 ].…”

“…Comparatively, tableting machines, the traditional counterparts, also come with considerable costs. Moreover, the raw materials used in 3D printing—similar to those used in conventional tablet manufacturing—do not incur additional expenses [ 89 , 119 , 156 ]. Furthermore, the majority of developed formulations generally eliminate the need for extra post-printing steps, thus not incurring added costs.…”

Altering Mechanical and Dissolution Properties of Coffee Deposit by Adding Glucose

“…One of the main challenges associated with droplet-based printing techniques in the preparation of personalized medicines is the development of pharmaceutical inks (similar to bioinks in bioprinting) with suitable mechanical characteristics and adjustable drug release time. 13,19,20 Pharmaceutical inks are meticulously formulated inks that contain drugs and excipient substances. The formulation and components of pharmaceutical inks are the keys to precise and adaptable material deposition in the printing process.…”

“…Biomedical additive manufacturing is gaining popularity for low-cost prototyping and manufacturing due to its advantages in noncontact printing, speed, and accuracy. − Recently, droplet-based two-dimensional (2D) and three-dimensional (3D) printing techniques like inkjet printing have become hot research focus for appropriate pharmaceutical applications, − allowing the creation of personalized medicine and targeted drug delivery system through automated control over drug doses and releases, making the vision of patient-specific treatment on the horizon tangible reality. ,,− However, further exploration and optimization are needed to fully utilize the capabilities of droplet-based 2D and 3D printing techniques in healthcare applications. One of the main challenges associated with droplet-based printing techniques in the preparation of personalized medicines is the development of pharmaceutical inks (similar to bioinks in bioprinting) with suitable mechanical characteristics and adjustable drug release time. ,, Pharmaceutical inks are meticulously formulated inks that contain drugs and excipient substances. The formulation and components of pharmaceutical inks are the keys to precise and adaptable material deposition in the printing process.…”