Inlays and the cornea

Fenner, Beau J.; Moriyama, Aline Silveira

doi:10.1016/j.exer.2021.108474

Cited by 17 publications

(23 citation statements)

References 61 publications

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“…4 Designers hoped it would negligibly affect UDVA as the paracentral light rays around the implant are unaltered. 7 A summary of the device properties and mechanism of action can be found in Table 1. As of 2018, the product is no longer available in the U.S. 14…”

Section: Product Design and Surgical Techniquementioning

confidence: 99%

“…14 The Presbia Flexivue Microlens is a transparent refractive corneal inlay of hydroxyethyl methacrylate and methyl methacrylate. 7 The device is 3.2mm in diameter with an inner hole diameter of 0.51mm. The central flat zone diameter is 1.6mm.…”

Section: Safety and Outcomesmentioning

confidence: 99%

“…These inlays are placed at varying depths of a patient’s stroma to improve near vision. 4 , 7 The product design, surgical technique, efficacy, and safety are discussed for each type of synthetic corneal inlay. Table 1 summarizes the device mechanisms of action, materials, and dimensions.…”

Section: Introductionmentioning

confidence: 99%

“… 4 Designers hoped it would negligibly affect UDVA as the paracentral light rays around the implant are unaltered. 7 A summary of the device properties and mechanism of action can be found in Table 1 . As of 2018, the product is no longer available in the U.S. 14

Figure 8 Corneal topography before ( A ) and after ( B ) Raindrop inlay implantation, showing the intended significant increase in central corneal steepness.…”

Section: Introductionmentioning

confidence: 99%

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Review of Presbyopia Treatment with Corneal Inlays and New Developments

Moshirfar

Henrie

Payne

et al. 2022

OPTH

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Presbyopia may represent the largest segment of refractive errors that is without an established and effective refractive surgery treatment. Corneal Inlays are materials (synthetic or allogenic) implanted in the stroma of patients' corneas to improve presbyopia. These inlays, introduced into the United States in 2015 via the small-aperture corneal inlay (KAMRA TM , SightLife Surgical/CorneaGen, Seattle, Washington, United States), were met with an initial wave of enthusiasm. Subsequent models like the shape-changing corneal inlay (RAINDROP TM , Revision Optics, Lake Forest, California, United States) offered excellent results for patients, but longer-term research raised questions about patient safety. At the time of this article, no synthetic corneal inlays are available in the United States for the correction of presbyopia. Other options for presbyopia correction include allograft corneal inlays, trifocal synthetic corneal inlays, pharmacologic therapies, scleral incisions or additive techniques and PresbyLASIK. Presently, allograft inlays consist of corneal lenticules removed from patients undergoing Small Incision Lenticule Extraction (SMILE). We will review corneal inlays and other alternative procedures that may provide effective and predictable treatments for patients with presbyopia.

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Section: Product Design and Surgical Techniquementioning

confidence: 99%

Section: Safety and Outcomesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“… 4 Designers hoped it would negligibly affect UDVA as the paracentral light rays around the implant are unaltered. 7 A summary of the device properties and mechanism of action can be found in Table 1 . As of 2018, the product is no longer available in the U.S. 14

Figure 8 Corneal topography before ( A ) and after ( B ) Raindrop inlay implantation, showing the intended significant increase in central corneal steepness.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Review of Presbyopia Treatment with Corneal Inlays and New Developments

Moshirfar

Henrie

Payne

et al. 2022

OPTH

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“…The small aperture IC-8 IOL (AcuFocus Inc., Irvine, CA, USA) is a newer EDOF IOL based on the KAMRA corneal inlay design (AcuFocus Inc., Irvine, CA, USA) [ 22 ]. The small aperture IC-8 IOL is a single piece hydrophobic acrylic posterior chamber IOL that combines pinhole technology through a central 3.23 mm black circular mask composed of polyvinylidene difluoride and carbon nanoparticles with a central 1.36 mm aperture.…”

Section: Introductionmentioning

confidence: 99%

Small Aperture IC-8 Extended-Depth-of-Focus Intraocular Lens in Cataract Surgery: A Systematic Review

Sánchez‐González

Sánchez-González

De-Hita-Cantalejo

et al. 2022

JCM

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The aim of this paper is to evaluate the visual outcomes and patient satisfaction of small aperture IC-8 IOLs in cataract patients with or without prior ocular events. A systematic review of full-length original English studies reporting the visual results of small aperture IC-8 IOL implantation after cataract surgery in three databases, PubMed, Web of Science and Scopus, was performed according to the PRISMA statement. The Quality Assessment Tool for case series studies from the National Heart, Lung, and Blood Institute was used to analyze the quality of the studies selected. The search provided 543 articles, of which 22 were included in this systematic review. Significant improvements in uncorrected distance visual acuity (UDVA); uncorrected intermediate visual acuity (UIVA); uncorrected near visual acuity (UNVA); perception of photic phenomena; and patient satisfaction have been reported. Unilateral and bilateral small aperture IC-8 IOL implantation reduces photic phenomena and provides good vision for all distances with high patient satisfaction and minimal postoperative complications. Therefore, the implantation of this IOL may be recommended for patients with cataracts, corneal irregularities and ocular trauma with partial aniridia.

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Theranostic‐Guided UV‐A Light Corneal Wavefront Photo‐Reshaping for Presbyopia Correction: A Preclinical Study

Lombardo,

Bernava,

Serrao

et al. 2024

Journal of Biophotonics

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This study investigated the effect of a theranostic‐guided UV‐A light corneal photo‐reshaping technique on corneal elevation and wavefront aberration (WA) in human donor eyes. A specialized platform, combining UV‐A light with corneal iontophoresis for controlled, patterned, riboflavin delivery, was used for both distribution assessment and concentration‐driven photopolymerization of corneal proteins. In all cases, a consistent riboflavin concentration gradient, with lower levels in the central prepupillary zone, was recorded. Corneal topography and WA measurements showed significant corneal steepening and smooth wavefront shaping, respectively, with a delay in the central 2.0 mm of the WA and advancement in the surrounding zone, as well as a 50% reduction in corneal spherical aberration over a 5.0 mm pupil size. Notably, the corneal optical quality, measured via modulation transfer function (MTF), remained stable. This incision‐free approach demonstrated the potential to extend focal range without compromising distance vision, presenting a new solution for presbyopia correction.

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Inlays and the cornea

Cited by 17 publications

References 61 publications

Review of Presbyopia Treatment with Corneal Inlays and New Developments

Review of Presbyopia Treatment with Corneal Inlays and New Developments

Small Aperture IC-8 Extended-Depth-of-Focus Intraocular Lens in Cataract Surgery: A Systematic Review

Theranostic‐Guided UV‐A Light Corneal Wavefront Photo‐Reshaping for Presbyopia Correction: A Preclinical Study

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